A 2017 review of pharmacotherapy for treating focal epilepsy: where are we now and how will treatment develop?

Pharmacogenomics in epilepsy

(2018) Simona Balestrini et al.   NEUROSCIENCE LETTERS

Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII)

(2017) Meir Bialer et al.   EPILEPSIA

Decrease in mortality of adult epilepsy patients since 1980: lessons learned from a hospital-based cohort

(2017) C. A. Granbichler et al.   EUROPEAN JOURNAL OF NEUROLOGY

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Brain stimulation as a neuromodulatory epilepsy therapy

(2017) Andreas Schulze-Bonhage   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Antiepileptic Drugs Under Investigation for Treatment of Focal Epilepsy

(2016) Pasquale Striano et al.   CLINICAL NEUROPHARMACOLOGY

Prevention of Epilepsy: Issues and Innovations

(2016) Dieter Schmidt et al.   Current Neurology and Neuroscience Reports

Quantifying antiepileptic drug effects using intrinsic excitability measures

(2016) Christian Meisel et al.   EPILEPSIA

Low-dose fenfluramine significantly reduces seizure frequency in Dravet syndrome: a prospective study of a new cohort of patients

(2016) A. Schoonjans et al.   EUROPEAN JOURNAL OF NEUROLOGY

Sirolimus for epilepsy in children with tuberous sclerosis complex

(2016) Iris E. Overwater et al.   NEUROLOGY

Preventing epileptogenesis: A realistic goal?

(2016) Gaetano Terrone et al.   PHARMACOLOGICAL RESEARCH

Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside

(2016) Avijit Dey et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Infections, inflammation and epilepsy

(2015) Annamaria Vezzani et al.   ACTA NEUROPATHOLOGICA

An open-label, prospective, exploratory study of patients with epilepsy switching from levetiracetam to brivaracetam

(2015) Stephen L. Yates et al.   EPILEPSY & BEHAVIOR

Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII)

(2015) Meir Bialer et al.   EPILEPSY RESEARCH

Perampanel for epilepsy with partial-onset seizures: a pharmacokinetic and pharmacodynamic evaluation

(2015) Andreas Schulze-Bonhage   Expert Opinion on Drug Metabolism & Toxicology

Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus

(2015) N. Wang et al.   NEUROSCIENCE

Intrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability over the wake/sleep cycle

(2015) Christian Meisel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pediatric super-refractory status epilepticus treated with allopregnanolone

(2014) Eileen Broomall et al.   ANNALS OF NEUROLOGY

ILAE Official Report: A practical clinical definition of epilepsy

(2014) Robert S. Fisher et al.   EPILEPSIA

Drug Interactions with the Newer Antiepileptic Drugs (AEDs)—Part 1: Pharmacokinetic and Pharmacodynamic Interactions Between AEDs

(2013) Philip N. Patsalos   CLINICAL PHARMACOKINETICS

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

Placebo-corrected efficacy of modern nonenzyme-inducing AEDs for refractory focal epilepsy: Systematic review and meta-analysis

(2012) Stefan Beyenburg et al.   EPILEPSIA

Finding a better drug for epilepsy: Preclinical screening strategies and experimental trial design

(2012) Michele Simonato et al.   EPILEPSIA

Retigabine for partial onset seizures

(2012) Sylvain Rheims et al.   Expert Review of Neurotherapeutics

Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy

(2012) Jerome Engel   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures

(2012) Jayne Abraham et al.   NEUROBIOLOGY OF DISEASE

Molecular biomarkers of epileptogenesis

(2011) Asla Pitkänen et al.   Biomarkers in Medicine

Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma

(2011) Wolfgang Löscher et al.   EPILEPSIA

Antiepileptic drug combinations—Have newer agents altered clinical outcomes?

(2011) Linda J. Stephen et al.   EPILEPSY RESEARCH

Risk of sudden unexpected death in epilepsy in patients given adjunctive antiepileptic treatment for refractory seizures: a meta-analysis of placebo-controlled randomised trials

(2011) Philippe Ryvlin et al.   LANCET NEUROLOGY

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

(2011) Mark McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

(2011) Wolfgang Löscher   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

A Pooled Analysis of Lacosamide Clinical Trial Data Grouped by Mechanism of Action of Concomitant Antiepileptic Drugs

(2010) John-Kenneth Sake et al.   CNS DRUGS

AED discontinuation may not be dangerous in seizure-free patients

(2010) Ettore Beghi   JOURNAL OF NEURAL TRANSMISSION

Treatment of newly diagnosed epilepsies: the shortcomings of SANAD

(2009) Colin D Ferrie et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited

(2009) Claude G. Wasterlain et al.   EPILEPSIA

Preventing and treating posttraumatic seizures: The human experience

(2009) Nancy R. Temkin   EPILEPSIA

Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

(2009) Patrick Kwan et al.   EPILEPSIA

Key factors in the discovery and development of new antiepileptic drugs

(2009) Meir Bialer et al.   NATURE REVIEWS DRUG DISCOVERY

Determinants of Quality of Life in People with Epilepsy

(2009) Ann Jacoby et al.   NEUROLOGIC CLINICS

Pharmacokinetic, Pharmacodynamic, and Pharmacogenetic Targeted Therapy of Antiepileptic Drugs

(2009) Gail D Anderson   THERAPEUTIC DRUG MONITORING

Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder

(2008) Jean-Bernard Manent et al.   NATURE MEDICINE