Understanding Pre-Eclampsia Using Alzheimer's Etiology: An Intriguing Viewpoint

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis

(2014) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Pre-eclampsia and cardiovascular disease

(2014) C. W. Chen et al.   CARDIOVASCULAR RESEARCH

Hypertension in Pregnancy

(2014) Amanda R. Vest et al.   Current Atherosclerosis Reports

Pre-eclampsia part 1: current understanding of its pathophysiology

(2014) Tinnakorn Chaiworapongsa et al.   Nature Reviews Nephrology

Low-Molecular Weight Heparin Increases Circulating sFlt-1 Levels and Enhances Urinary Elimination

(2014) Henning Hagmann et al.   PLoS One

Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia

(2014) I. A. Buhimschi et al.   Science Translational Medicine

Transthyretin Is Dysregulated in Preeclampsia, and Its Native Form Prevents the Onset of Disease in a Preclinical Mouse Model

(2013) Satyan S. Kalkunte et al.   AMERICAN JOURNAL OF PATHOLOGY

Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia

(2013) Akitoshi Nakashima et al.   Autophagy

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

(2013) Roberta Cascella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Angiogenic factors in preeclampsia

(2013) Arvind Goel et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The amyloid precursor protein: A biochemical enigma in brain development, function and disease

(2013) Natalia N. Nalivaeva et al.   FEBS LETTERS

Gestational Hypoxia Induces Preeclampsia-Like Symptoms via Heightened Endothelin-1 Signaling in Pregnant Rats

(2013) Jianjun Zhou et al.   HYPERTENSION

Angiogenic Factors in Diagnosis, Management, and Research in Preeclampsia

(2013) Sarosh Rana et al.   HYPERTENSION

Clinical characterization and outcomes of preeclampsia with normal angiogenic profile

(2013) Sarosh Rana et al.   HYPERTENSION IN PREGNANCY

Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells

(2013) Raquel J. Nunes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Transthyretin Inhibition of  -Amyloid Aggregation In Vitro

(2013) X. Li et al.   JOURNAL OF NEUROSCIENCE

If we know so much about preeclampsia, why haven’t we cured the disease?

(2013) James M. Roberts et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

A review of the mechanism for poor placentation in early-onset preeclampsia: the role of autophagy in trophoblast invasion and vascular remodeling

(2013) Shigeru Saito et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Cytokines as Key Players in the Pathophysiology of Preeclampsia

(2013) Raj Raghupathy   MEDICAL PRINCIPLES AND PRACTICE

Pre-treatment with calcium prevents endothelial cell activation induced by multiple activators, necrotic trophoblastic debris or IL-6 or preeclamptic sera: Possible relevance to the pathogenesis of preeclampsia

(2013) Q. Chen et al.   PLACENTA

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus

(2013) Arvind Suresh et al.   PLoS One

Autophagy in the Human Placenta throughout Gestation

(2013) Tai-Ho Hung et al.   PLoS One

Effect of Prenatal Hypoxia in Transgenic Mouse Models of Preeclampsia and Fetal Growth Restriction

(2013) C. F. Rueda-Clausen et al.   Reproductive Sciences

Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight

(2013) Takashige Kawakami et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

Protein Misfolding, Aggregation, and Autophagy After Brain Ischemia

(2013) Tianfei Luo et al.   Translational Stroke Research

Endothelin-1 Induces Endoplasmic Reticulum Stress by Activating the PLC-IP3 Pathway

(2012) Arjun Jain et al.   AMERICAN JOURNAL OF PATHOLOGY

The Promise of Angiogenic Markers for the Early Diagnosis and Prediction of Preeclampsia

(2012) H. Hagmann et al.   CLINICAL CHEMISTRY

Endoplasmic reticulum stress induced by oxidative stress in decidual cells: a possible mechanism of early pregnancy loss

(2012) Hui-Juan Gao et al.   MOLECULAR BIOLOGY REPORTS

Transthyretin Aggregates Induce Production of Reactive Nitrogen Species

(2012) Vai-Hong Fong et al.   Neurodegenerative Diseases

MIR-210 modulates mitochondrial respiration in placenta with preeclampsia

(2012) S. Muralimanoharan et al.   PLACENTA

Increased Autophagy in Placentas of Intrauterine Growth-Restricted Pregnancies

(2012) Tai-Ho Hung et al.   PLoS One

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

A Critical Role of Interleukin-10 in Modulating Hypoxia-Induced Preeclampsia-Like Disease in Mice

(2011) Zhongbin Lai et al.   HYPERTENSION

Unfolded protein response in cancer: the Physician's perspective

(2011) Xuemei Li et al.   Journal of Hematology & Oncology

Soluble Aβ oligomer production and toxicity

(2011) Megan E. Larson et al.   JOURNAL OF NEUROCHEMISTRY

Proteolytic processing of Alzheimer’s β-amyloid precursor protein

(2011) Han Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?

(2011) Xinyi Li et al.   Molecular Neurodegeneration

Ontogenic changes in placental transthyretin

(2011) J. Patel et al.   PLACENTA

Increased endoplasmic reticulum stress in decidual tissue from pregnancies complicated by fetal growth restriction with and without pre-eclampsia

(2011) I.A. Lian et al.   PLACENTA

Sera from Preeclampsia Patients Elicit Symptoms of Human Disease in Mice and Provide a Basis for an in Vitro Predictive Assay

(2010) Satyan Kalkunte et al.   AMERICAN JOURNAL OF PATHOLOGY

Animal Models of Pre-eclampsia

(2010) Neroli Sunderland et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Autophagy and protein aggregation after brain ischemia

(2010) Chunli Liu et al.   JOURNAL OF NEUROCHEMISTRY

Pre-eclampsia

(2010) Eric AP Steegers et al.   LANCET

Protein Misfolding Induces Hypoxic Preconditioning via a Subset of the Unfolded Protein Response Machinery

(2010) X. R. Mao et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Transthyretin Internalization by Sensory Neurons Is Megalin Mediated and Necessary for Its Neuritogenic Activity

(2009) C. E. Fleming et al.   JOURNAL OF NEUROSCIENCE

Novel approaches for mechanistic understanding and predicting preeclampsia

(2009) Satyan Kalkunte et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Gabor Than Award Lecture 2008: Pre-eclampsia – From Placental Oxidative Stress to Maternal Endothelial Dysfunction

(2009) T. Cindrova-Davies   PLACENTA

Placental Stress and Pre-eclampsia: A Revised View

(2009) C.W.G. Redman et al.   PLACENTA

The Endoplasmic Reticulum Stress of Placental Impoverishment

(2008) Christopher W.G. Redman   AMERICAN JOURNAL OF PATHOLOGY

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

(2008) Hong-wa Yung et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of endoplasmic reticulum stress response following trauma-hemorrhage

(2008) Bixi Jian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structural Insight into pH-Induced Conformational Changes within the Native Human Transthyretin Tetramer

(2008) Satheesh K. Palaninathan et al.   JOURNAL OF MOLECULAR BIOLOGY

Placental Endoplasmic Reticulum Stress and Oxidative Stress in the Pathophysiology of Unexplained Intrauterine Growth Restriction and Early Onset Preeclampsia

(2008) G.J. Burton et al.   PLACENTA

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of A  toxicity

(2008) J. N. Buxbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy-Related Proteins, LC3 and Beclin-1, in Placentas From Pregnancies Complicated by Preeclampsia

(2008) Soo-Young Oh et al.   Reproductive Sciences

The role of the placenta in thyroid hormone delivery to the fetus

(2008) Shiao Y Chan et al.   Nature clinical practice. Endocrinology & metabolism