Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function

HCMV modulation of cellular PI3K/AKT/mTOR signaling: New opportunities for therapeutic intervention?

(2019) Aaron M. Altman et al.   ANTIVIRAL RESEARCH

Control of viral infections by epigenetic-targeted therapy

(2019) Zeina Nehme et al.   Clinical Epigenetics

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

(2019) Sara Botto et al.   mBio

5‑Azacytidine treatment results in nuclear exclusion of DNA methyltransferase‑1, as well as reduced proliferation and invasion in human cytomegalovirus‑infected glioblastoma cells

(2019) Atosa Estekizadeh et al.   ONCOLOGY REPORTS

HCMV latency: what regulates the regulators?

(2019) Elizabeth Elder et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

The Transcriptome of Latent Human Cytomegalovirus

(2019) Michal Schwartz et al.   JOURNAL OF VIROLOGY

The isoquinoline alkaloid berberine inhibits human cytomegalovirus replication by interfering with the viral Immediate Early-2 (IE2) protein transactivating activity.

(2019) Anna Luganini et al.   ANTIVIRAL RESEARCH

Targeting PI3K signaling in cancer: Challenges and advances

(2019) Maria Chiara De Santis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Human Cytomegalovirus Latency and Reactivation in Allogeneic Hematopoietic Stem Cell Transplant Recipients

(2019) Lauren Stern et al.   Frontiers in Microbiology

An overview of letermovir: a cytomegalovirus prophylactic option

(2019) Giuseppe Gerna et al.   EXPERT OPINION ON PHARMACOTHERAPY

Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter

(2019) Liane Dupont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Cytomegalovirus Cell Tropism and Host Cell Receptors

(2019) Gerna et al.   Vaccines

Safety considerations with current and emerging antiviral therapies for cytomegalovirus infection in transplantation

(2019) Guy El Helou et al.   Expert Opinion On Drug Safety

Alternative promoters drive human cytomegalovirus reactivation from latency

(2019) Donna Collins-McMillen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Nuclear Events after Herpesviral Infection

(2019) Florian Full et al.   Journal of Clinical Medicine

Advances in the treatment of cytomegalovirus

(2019) B A Krishna et al.   BRITISH MEDICAL BULLETIN

Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency

(2019) Jason Buehler et al.   PLoS Pathogens

HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation

(2019) Iliyana Mikell et al.   PLoS Pathogens

CMV Prevention and Treatment in Transplantation: What’s New in 2019

(2019) Anat Stern et al.   Current Infectious Disease Reports

Human cytomegalovirus-encoded MicroRNAs: A master regulator of latent infection

(2019) Abualgasim Elgaili Abdalla et al.   INFECTION GENETICS AND EVOLUTION

Interferon-Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency

(2019) Elizabeth G. Elder et al.   mBio

The Artemisinin Derivative Artemisone Is a Potent Inhibitor of Human Cytomegalovirus Replication

(2018) E. Oiknine-Djian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Modular cell-based platform for high throughput identification of compounds that inhibit a viral interferon antagonist of choice

(2018) Andri Vasou et al.   ANTIVIRAL RESEARCH

Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein

(2018) Beatrice Mercorelli et al.   ANTIVIRAL RESEARCH

Artesunate-derived monomeric, dimeric and trimeric experimental drugs – Their unique mechanistic basis and pronounced antiherpesviral activity

(2018) Friedrich Hahn et al.   ANTIVIRAL RESEARCH

Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin

(2018) Aysun Çapcı Karagöz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

PML nuclear bodies: from architecture to function

(2018) Valérie Lallemand-Breitenbach et al.   CURRENT OPINION IN CELL BIOLOGY

Drug-resistant cytomegalovirus

(2018) Raymund R. Razonable   Current Opinion in Organ Transplantation

Modulation of the innate immune response by human cytomegalovirus

(2018) Matteo Biolatti et al.   INFECTION GENETICS AND EVOLUTION

SUMOylation of IE2p86 is required for efficient autorepression of the human cytomegalovirus major immediate-early promoter

(2018) Nina Reuter et al.   JOURNAL OF GENERAL VIROLOGY

Digitoxin Suppresses Human Cytomegalovirus Replication via Na+, K+/ATPase α1 Subunit-Dependent AMP-Activated Protein Kinase and Autophagy Activation

(2018) Rupkatha Mukhopadhyay et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Immediate-Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus

(2018) Cong-Cong Wu et al.   JOURNAL OF VIROLOGY

Maribavir, brincidofovir and letermovir: Efficacy and safety of new antiviral drugs for treating cytomegalovirus infections

(2018) P. Frange et al.   MEDECINE ET MALADIES INFECTIEUSES

Multiplex CRISPR/Cas9 system impairs HCMV replication by excising an essential viral gene

(2018) Janina Gergen et al.   PLoS One

Congenital cytomegalovirus infection

(2018) Karen B. Fowler et al.   SEMINARS IN PERINATOLOGY

Vaccination against the human cytomegalovirus

(2018) Stanley A. Plotkin et al.   VACCINE

Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing

(2018) Miri Shnayder et al.   mBio

Clinical Use of Digitalis: A State of the Art Review

(2018) Thomas F. Whayne   American Journal of Cardiovascular Drugs

New therapies for human cytomegalovirus infections

(2018) William J. Britt et al.   ANTIVIRAL RESEARCH

A fifty-year odyssey: Prospects for a cytomegalovirus vaccine in transplant and congenital infection

(2018) Don J. Diamond et al.   Expert Review of Vaccines

The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview

(2018) Luciano Amarelle et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency

(2018) Michael A. Rak et al.   JOURNAL OF VIROLOGY

Expression of Human Cytomegalovirus IE1 Leads to Accumulation of Mono-SUMOylated PML That Is Protected from Degradation by HSV-1 ICP0

(2018) Wangheng Hou et al.   JOURNAL OF VIROLOGY

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

Feedback-mediated signal conversion promotes viral fitness

(2018) Noam Vardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation

(2018) Donna Collins-McMillen et al.   Viruses-Basel

The Interplay between Human Cytomegalovirus and Pathogen Recognition Receptor Signaling

(2018) Mariana Marques et al.   Viruses-Basel

Dual Platform Long-Read RNA-Sequencing Dataset of the Human Cytomegalovirus Lytic Transcriptome

(2018) Zsolt Balázs et al.   Frontiers in Genetics

In vivo proof-of-concept for two experimental antiviral drugs, both directed to cellular targets, using a murine cytomegalovirus model

(2018) Eric Sonntag et al.   ANTIVIRAL RESEARCH

Targeting the terminase: An important step forward in the treatment and prophylaxis of human cytomegalovirus infections

(2018) Brian G. Gentry et al.   ANTIVIRAL RESEARCH

Role of PDGF receptor-α during human cytomegalovirus entry into fibroblasts

(2018) Kai Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions for Medical Translation that Survived the “Test of Time”

(2018) Matthias Reddehase et al.   Viruses-Basel

High-throughput screening of a GlaxoSmithKline protein kinase inhibitor set identifies an inhibitor of human cytomegalovirus replication that prevents CREB and histone H3 post-translational modification

(2017) Amina S Khan et al.   JOURNAL OF GENERAL VIROLOGY

Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing

(2017) Christopher Bianco et al.   JOURNAL OF VIROLOGY

Correlation Between Expression of Recombinant Proteins and Abundance of H3K4Me3 on the Enhancer of Human Cytomegalovirus Major Immediate-Early Promoter

(2017) Benjamin P. C. Soo et al.   MOLECULAR BIOTECHNOLOGY

FDA-Approved Oligonucleotide Therapies in 2017

(2017) Cy A. Stein et al.   MOLECULAR THERAPY

Na+i,K+i-Dependent and -Independent Signaling Triggered by Cardiotonic Steroids: Facts and Artifacts

(2017) Sergei Orlov et al.   MOLECULES

Inhibition of human cytomegalovirus immediate early gene expression and growth by a novel RNase P ribozyme variant

(2017) Xu Sun et al.   PLoS One

Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency

(2017) Shu Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150

(2017) Xuekui Yu et al.   SCIENCE

A synthetic human cytomegalovirus pp65-IE1 fusion antigen efficiently induces and expands virus specific T cells

(2017) Ellen K. Link et al.   VACCINE

The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting

(2017) Julia Hornig et al.   VIROLOGY

Synthesis of Thymoquinone–Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents

(2017) Tony Fröhlich et al.   ACS Medicinal Chemistry Letters

Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions

(2017) Felix E. Held et al.   Nature Communications

Antiviral treatment strategies based on gene silencing and genome editing

(2017) Roger Badia et al.   Current Opinion in Virology

Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase

(2017) Xi-Juan Liu et al.   PLoS Pathogens

The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication

(2017) Yao-Tang Lin et al.   PLoS Pathogens

Human Cytomegalovirus IE2 86 kDa Protein Induces STING Degradation and Inhibits cGAMP-Mediated IFN-β Induction

(2017) Jung-Eun Kim et al.   Frontiers in Microbiology

Long-Read Sequencing of Human Cytomegalovirus Transcriptome Reveals RNA Isoforms Carrying Distinct Coding Potentials

(2017) Zsolt Balázs et al.   Scientific Reports

Artesunate demonstrates in vitro synergism with several antiviral agents against human cytomegalovirus

(2016) Emilien Drouot et al.   ANTIVIRAL THERAPY

High levels of histone H3 acetylation at the CMV promoter are predictive of stable expression in Chinese hamster ovary cells

(2016) Benjamin Moritz et al.   BIOTECHNOLOGY PROGRESS

Human cytomegalovirus miR-UL112-1 promotes the down-regulation of viral immediate early-gene expression during latency to prevent T-cell recognition of latently infected cells

(2016) Betty Lau et al.   JOURNAL OF GENERAL VIROLOGY

Two Polypyrimidine Tracts in Intron 4 of the Major Immediate Early Gene Are Critical for Gene Expression Switching from IE1 to IE2 and for Replication of Human Cytomegalovirus

(2016) Wangheng Hou et al.   JOURNAL OF VIROLOGY

Multiple Transcripts Encode Full-Length Human Cytomegalovirus IE1 and IE2 Proteins during Lytic Infection

(2016) Kyle C. Arend et al.   JOURNAL OF VIROLOGY

Emerging Role of PML Nuclear Bodies in Innate Immune Signaling

(2016) Myriam Scherer et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34 + Human Progenitor Cells

(2016) Jung Heon Kim et al.   JOURNAL OF VIROLOGY

The Human Cytomegalovirus IE1 Protein Antagonizes PML Nuclear Body-Mediated Intrinsic Immunity via the Inhibition of PML De Novo SUMOylation

(2016) Eva-Maria Schilling et al.   JOURNAL OF VIROLOGY

Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication

(2016) Tobias Cohen et al.   JOURNAL OF VIROLOGY

Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection

(2016) Benjamin A. Diner et al.   mBio

Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication

(2016) Jason Buehler et al.   PLoS Pathogens

Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response

(2016) Thomas Harwardt et al.   PLoS Pathogens

Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators

(2016) Ye Ji Kim et al.   PLoS Pathogens

Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome

(2016) Qianglin Fang et al.   eLife

Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome

(2016) Gabriella Campadelli-Fiume et al.   Annual Review of Virology

External guide sequence technology: a path to development of novel antimicrobial therapeutics

(2015) Carol Davies-Sala et al.   Annals of the New York Academy of Sciences

A Novel CDK7 Inhibitor of the Pyrazolotriazine Class Exerts Broad-Spectrum Antiviral Activity at Nanomolar Concentrations

(2015) Corina Hutterer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Human Cytomegalovirus Replication by Artemisinins: Effects Mediated through Cell Cycle Modulation

(2015) Sujayita Roy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of a high-content screen for the identification of inhibitors directed against the early steps of the cytomegalovirus infectious cycle

(2015) Thomas J. Gardner et al.   ANTIVIRAL RESEARCH

The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65

(2015) Corina Hutterer et al.   ANTIVIRAL RESEARCH

Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities

(2015) Christoph Reiter et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids

(2015) Christoph Reiter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Investigation of the dynamics of the viral immediate-early protein 1 in different conformations and oligomerization states

(2015) Joachim D. Stump et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The c-Jun N-terminal kinase inhibitor SP600125 inhibits human cytomegalovirus replication

(2015) Huiping Zhang et al.   JOURNAL OF MEDICAL VIROLOGY

Differentiation-Coupled Induction of Human Cytomegalovirus Replication by Union of the Major Enhancer Retinoic Acid, Cyclic AMP, and NF-κB Response Elements

(2015) Jinxiang Yuan et al.   JOURNAL OF VIROLOGY

Characterization of Recombinant Human Cytomegaloviruses Encoding IE1 Mutants L174P and 1-382 Reveals that Viral Targeting of PML Bodies Perturbs both Intrinsic and Innate Immune Responses

(2015) Myriam Scherer et al.   JOURNAL OF VIROLOGY

Human cytomegalovirus riding the cell cycle

(2015) Deborah H. Spector   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease

(2015) David W. Kimberlin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Current Controversies in Diagnosis, Management, and Prevention of Congenital Cytomegalovirus: Updates for the Pediatric Practitioner

(2015) Gail J. Harrison   PEDIATRIC ANNALS

Ex vivo model of congenital cytomegalovirus infection and new combination therapies

(2015) L. Morère et al.   PLACENTA

Cytomegalovirus latency and reactivation: recent insights into an age old problem

(2015) Liane Dupont et al.   REVIEWS IN MEDICAL VIROLOGY

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

CMV promoter mutants with a reduced propensity to productivity loss in CHO cells

(2015) Benjamin Moritz et al.   Scientific Reports

Positive Role of Promyelocytic Leukemia Protein in Type I Interferon Response and Its Regulation by Human Cytomegalovirus

(2015) Young-Eui Kim et al.   PLoS Pathogens

Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

(2015) Benjamin Rauwel et al.   eLife

Cellular defense against latent colonization foiled by human cytomegalovirus UL138 protein

(2015) S. H. Lee et al.   Science Advances

New Cell-Signaling Pathways for Controlling Cytomegalovirus Replication

(2014) S. Roy et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The 6-Aminoquinolone WC5 Inhibits Different Functions of the Immediate-Early 2 (IE2) Protein of Human Cytomegalovirus That Are Essential for Viral Replication

(2014) Beatrice Mercorelli et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Maintenance and Replication of the Human Cytomegalovirus Genome during Latency

(2014) Margaret Tarrant-Elorza et al.   Cell Host & Microbe

The human cytomegalovirus IE1 protein: past and present developments

(2014) Myriam Scherer et al.   Future Virology

The pathogenesis of human cytomegalovirus

(2014) Paul Griffiths et al.   JOURNAL OF PATHOLOGY

Human Cytomegalovirus Replication Is Strictly Inhibited by siRNAs Targeting UL54, UL97 or UL122/123 Gene Transcripts

(2014) Stuart T. Hamilton et al.   PLoS One

Identification and HLA-Tetramer-Validation of Human CD4+ and CD8+ T Cell Responses against HCMV Proteins IE1 and IE2

(2014) Peter Braendstrup et al.   PLoS One

Analysis of Human Cytomegalovirus-Encoded SUMO Targets and Temporal Regulation of SUMOylation of the Immediate-Early Proteins IE1 and IE2 during Infection

(2014) Eui Tae Kim et al.   PLoS One

Manipulation of host pathways by human cytomegalovirus: insights from genome-wide studies

(2014) Yifat Cohen et al.   Seminars in Immunopathology

Progress on pursuit of human cytomegalovirus vaccines for prevention of congenital infection and disease

(2014) Tong-Ming Fu et al.   VACCINE

The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1) Protein Disrupts Type II Inteferon Signaling

(2014) Bindu Raghavan et al.   Viruses-Basel

Digitoxin Analogues with Improved Anticytomegalovirus Activity

(2014) Hongyi Cai et al.   ACS Medicinal Chemistry Letters

Educating women about congenital cytomegalovirus: assessment of health education materials through a web-based survey

(2014) Simani M Price et al.   BMC Womens Health

Progress on human cytomegalovirus vaccines for prevention of congenital infection and disease

(2014) Dai Wang et al.   Current Opinion in Virology

Cytomegalovirus microRNAs

(2014) Lauren Hook et al.   Current Opinion in Virology

Mitogen and Stress Activated Kinases Act Co-operatively with CREB during the Induction of Human Cytomegalovirus Immediate-Early Gene Expression from Latency

(2014) Verity G. Kew et al.   PLoS Pathogens

Crystal Structure of Cytomegalovirus IE1 Protein Reveals Targeting of TRIM Family Member PML via Coiled-Coil Interactions

(2014) Myriam Scherer et al.   PLoS Pathogens

Immediate-Early (IE) gene regulation of cytomegalovirus: IE1- and pp71-mediated viral strategies against cellular defenses

(2014) Lilith Torres et al.   VIROLOGICA SINICA

Unique and Highly Selective Anticytomegalovirus Activities of Artemisinin-Derived Dimer Diphenyl Phosphate Stem from Combination of Dimer Unit and a Diphenyl Phosphate Moiety

(2013) Ran He et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroCombination of Anti-Cytomegalovirus Compounds Acting through Different Targets: Role of the Slope Parameter and Insights into Mechanisms of Action

(2013) Hongyi Cai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus

(2013) R. Germi et al.   ANTIVIRAL RESEARCH

Natural antisense transcripts of UL123 packaged in human cytomegalovirus virions

(2013) Cui-Qing Yang et al.   ARCHIVES OF VIROLOGY

Human cytomegalovirus immediate early proteins promote degradation of connexin 43 and disrupt gap junction communication: implications for a role in gliomagenesis

(2013) Zahidul Khan et al.   CARCINOGENESIS

Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion

(2013) Tuo Li et al.   Cell Host & Microbe

Design, Synthesis, and Evaluation of WC5 Analogues as Inhibitors of Human Cytomegalovirus Immediate-Early 2 Protein, a Promising Target for Anti-HCMV Treatment

(2013) Serena Massari et al.   ChemMedChem

Hyperimmunoglobulin for Prevention of Congenital Cytomegalovirus Disease

(2013) Giovanni Nigro et al.   CLINICAL INFECTIOUS DISEASES

The “Silent” Global Burden of Congenital Cytomegalovirus

(2013) Sheetal Manicklal et al.   CLINICAL MICROBIOLOGY REVIEWS

Human Cytomegalovirus Major Immediate Early 1 Protein Targets Host Chromosomes by Docking to the Acidic Pocket on the Nucleosome Surface

(2013) K. Mucke et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus pUL97 Regulates the Viral Major Immediate Early Promoter by Phosphorylation-Mediated Disruption of Histone Deacetylase 1 Binding

(2013) T. M. Bigley et al.   JOURNAL OF VIROLOGY

Polycomb Repressive Complex 2 Silences Human Cytomegalovirus Transcription in Quiescent Infection Models

(2013) C. G. Abraham et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus IE1 Protein Disrupts Interleukin-6 Signaling by Sequestering STAT3 in the Nucleus

(2013) J. M. Reitsma et al.   JOURNAL OF VIROLOGY

Artemisinins: Pharmacological actions beyond anti-malarial

(2013) Wanxing Eugene Ho et al.   PHARMACOLOGY & THERAPEUTICS

Nucleosome maps of the human cytomegalovirus genome reveal a temporal switch in chromatin organization linked to a major IE protein

(2013) E. Zalckvar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the JMJD2 Histone Demethylases to Epigenetically Control Herpesvirus Infection and Reactivation from Latency

(2013) Y. Liang et al.   Science Translational Medicine

Epigenetic Control of Cytomegalovirus Latency and Reactivation

(2013) Xue-feng Liu et al.   Viruses-Basel

A Novel Selective LSD1/KDM1A Inhibitor Epigenetically Blocks Herpes Simplex Virus Lytic Replication and Reactivation from Latency

(2013) Y. Liang et al.   mBio

The HCMV gH/gL/UL128-131 Complex Triggers the Specific Cellular Activation Required for Efficient Viral Internalization into Target Monocytes

(2013) Maciej T. Nogalski et al.   PLoS Pathogens

Cis and Trans Acting Factors Involved in Human Cytomegalovirus Experimental and Natural Latent Infection of CD14 (+) Monocytes and CD34 (+) Cells

(2013) Cyprian C. Rossetto et al.   PLoS Pathogens

Artemisinin-Derived Dimer Diphenyl Phosphate Is an Irreversible Inhibitor of Human Cytomegalovirus Replication

(2012) Ran He et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human Cytomegalovirus Inhibition by Cardiac Glycosides: Evidence for Involvement of the hERG Gene

(2012) Arun Kapoor et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

17-allylamino-17-(demethoxy)geldanamycin (17-AAG) is a potent and effective inhibitor of human cytomegalovirus replication in primary fibroblast cells

(2012) David L. Evers et al.   ARCHIVES OF VIROLOGY

An Endogenous Accelerator for Viral Gene Expression Confers a Fitness Advantage

(2012) Melissa W. Teng et al.   CELL

Early Primary Cytomegalovirus Infection in Pregnancy: Maternal Hyperimmunoglobulin Therapy Improves Outcomes Among Infants at 1 Year of Age

(2012) S. Visentin et al.   CLINICAL INFECTIOUS DISEASES

Use of cytomegalovirus hyperimmunoglobulin for prevention of congenital cytomegalovirus disease: a retrospective analysis

(2012) Horst Buxmann et al.   JOURNAL OF PERINATAL MEDICINE

Histone H3 Lysine 4 Methylation Marks Postreplicative Human Cytomegalovirus Chromatin

(2012) Alexandra Nitzsche et al.   JOURNAL OF VIROLOGY

RNA Interference-Mediated Targeting of Human Cytomegalovirus Immediate-Early or Early Gene Products Inhibits Viral Replication with Differential Effects on Cellular Functions

(2012) X. E et al.   JOURNAL OF VIROLOGY

Decoding Human Cytomegalovirus

(2012) N. Stern-Ginossar et al.   SCIENCE

The next generation recombinant human cytomegalovirus vaccine candidates—Beyond gB

(2012) Anders E. Lilja et al.   VACCINE

Snapshots: Chromatin control of viral infection

(2012) David M. Knipe et al.   VIROLOGY

The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication

(2012) Grazia Rosaria Gariano et al.   PLoS Pathogens

The unique antiviral activity of artesunate is broadly effective against human cytomegaloviruses including therapy-resistant mutants

(2011) Sunwen Chou et al.   ANTIVIRAL RESEARCH

Human cytomegalovirus kinetics following institution of artesunate after hematopoietic stem cell transplantation

(2011) Dana G. Wolf et al.   ANTIVIRAL RESEARCH

Promoter methylation and transgene copy numbers predict unstable protein production in recombinant chinese hamster ovary cell lines

(2011) Andrea Osterlehner et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cytomegalovirus: pathogen, paradigm, and puzzle

(2011) Michael Boeckh et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunoglobulin Therapy of Fetal Cytomegalovirus Infection Occurring in the First Half of Pregnancy--A Case-Control Study of the Outcome in Children

(2011) G. Nigro et al.   JOURNAL OF INFECTIOUS DISEASES

Role of Promyelocytic Leukemia Protein in Host Antiviral Defense

(2011) Marie-Claude Geoffroy et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Human Cytomegalovirus Infection Causes Degradation of Sp100 Proteins That Suppress Viral Gene Expression

(2011) Y.-E. Kim et al.   JOURNAL OF VIROLOGY

Evidence for a Dual Antiviral Role of the Major Nuclear Domain 10 Component Sp100 during the Immediate-Early and Late Phases of the Human Cytomegalovirus Replication Cycle

(2011) N. Tavalai et al.   JOURNAL OF VIROLOGY

An Artemisinin-Derived Dimer Has Highly Potent Anti-Cytomegalovirus (CMV) and Anti-Cancer Activities

(2011) Ran He et al.   PLoS One

Human cytomegalovirus activation of ERK and myeloid cell leukemia-1 protein correlates with survival of latently infected cells

(2011) M. B. Reeves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution human cytomegalovirus transcriptome

(2011) D. Gatherer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How to control an infectious bead string: nucleosome-based regulation and targeting of herpesvirus chromatin

(2011) Michael Nevels et al.   REVIEWS IN MEDICAL VIROLOGY

Implementing neonatal screening for congenital cytomegalovirus: addressing the deafness of policy makers

(2011) Jutte J.C. de Vries et al.   REVIEWS IN MEDICAL VIROLOGY

Human cytomegalovirus immediate early gene expression in the osteosarcoma line U2OS is repressed by the cell protein ATRX

(2011) Steven McFarlane et al.   VIRUS RESEARCH

Human Cytomegalovirus IE1 Protein Elicits a Type II Interferon-Like Host Cell Response That Depends on Activated STAT1 but Not Interferon-γ

(2011) Theresa Knoblach et al.   PLoS Pathogens

The 6-Aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by Interfering with the Transactivating Activity of Viral Immediate-Early 2 Protein

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Antiviral activity of ganciclovir and artesunate towards human cytomegalovirus in astrocytoma cells

(2010) Nathalie Schnepf et al.   ANTIVIRAL RESEARCH

Inhibition of Human Cytomegalovirus Infection by IE86-Specific Short Hairpin RNA-Mediated RNA Interference

(2010) Zhiqiang BAI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The multi-targeted kinase inhibitor sorafenib inhibits human cytomegalovirus replication

(2010) Martin Michaelis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Artesunate is Ineffective in Controlling Valganciclovir-Resistant Cytomegalovirus Infection

(2010) P. Kar Han Lau et al.   CLINICAL INFECTIOUS DISEASES

T-cell therapy for cytomegalovirus infection

(2010) Tan S Mui et al.   Current Opinion in Organ Transplantation

DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines

(2010) Yuansheng Yang et al.   JOURNAL OF BIOTECHNOLOGY

PI3K-Dependent Upregulation of Mcl-1 by Human Cytomegalovirus Is Mediated by Epidermal Growth Factor Receptor and Inhibits Apoptosis in Short-Lived Monocytes

(2010) G. Chan et al.   JOURNAL OF IMMUNOLOGY

Human Cytomegalovirus pUL83 Stimulates Activity of the Viral Immediate-Early Promoter through Its Interaction with the Cellular IFI16 Protein

(2010) I. M. Cristea et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus IE72 Protein Interacts with the Transcriptional Repressor hDaxx To Regulate LUNA Gene Expression during Lytic Infection

(2010) M. Reeves et al.   JOURNAL OF VIROLOGY

Artemisinin-Derived Dimers Have Greatly Improved Anti-Cytomegalovirus Activity Compared to Artemisinin Monomers

(2010) Ravit Arav-Boger et al.   PLoS One

Divergent susceptibilities of human herpesvirus 6 variants to type I interferons

(2010) J. Jaworska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection

(2010) Michael J. Cannon et al.   REVIEWS IN MEDICAL VIROLOGY

Chromatin-mediated regulation of cytomegalovirus gene expression

(2010) Matthew B. Reeves   VIRUS RESEARCH

Intrinsic cellular defense mechanisms targeting human cytomegalovirus

(2010) Nina Tavalai et al.   VIRUS RESEARCH

Human Cytomegalovirus UL29/28 Protein Interacts with Components of the NuRD Complex Which Promote Accumulation of Immediate-Early RNA

(2010) Scott S. Terhune et al.   PLoS Pathogens

A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes

(2009) Meike Chevillotte et al.   ANTIVIRAL RESEARCH

Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection

(2009) John Sinclair   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Deletion of the rat cytomegalovirus immediate-early 1 gene results in a virus capable of establishing latency, but with lower levels of acute virus replication and latency that compromise reactivation efficiency

(2009) G. R. Sandford et al.   JOURNAL OF GENERAL VIROLOGY

Lytic infection of permissive cells with human cytomegalovirus is regulated by an intrinsic 'pre-immediate-early' repression of viral gene expression mediated by histone post-translational modification

(2009) I. J. Groves et al.   JOURNAL OF GENERAL VIROLOGY

The Mouse Cytomegalovirus Immediate-Early 1 Gene Is Not Required for Establishment of Latency or for Reactivation in the Lungs

(2009) A. Busche et al.   JOURNAL OF VIROLOGY

Importance of Covalent and Noncovalent SUMO Interactions with the Major Human Cytomegalovirus Transactivator IE2p86 for Viral Infection

(2009) A. Berndt et al.   JOURNAL OF VIROLOGY

Physical Requirements and Functional Consequences of Complex Formation between the Cytomegalovirus IE1 Protein and Human STAT2

(2009) S. Krauss et al.   JOURNAL OF VIROLOGY

Analysis of Human Cytomegalovirus-Encoded MicroRNA Activity during Infection

(2009) N. Stern-Ginossar et al.   JOURNAL OF VIROLOGY

Conditional and reversible disruption of essential herpesvirus proteins

(2009) Mandy Glaß et al.   NATURE METHODS

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Transgene Expression Is Associated with Copy Number and Cytomegalovirus Promoter Methylation in Transgenic Pigs

(2009) Qingran Kong et al.   PLoS One

Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motility

(2009) Gary Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2009) Christina Paulus et al.   REVIEWS IN MEDICAL VIROLOGY

Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies

(2009) Nina Tavalai et al.   Viruses-Basel

The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses

(2009) Christina Paulus et al.   Viruses-Basel

A 6-Aminoquinolone Compound, WC5, with Potent and Selective Anti-Human Cytomegalovirus Activity

(2008) B. Mercorelli et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Establishment of a Cell-Based Assay for Screening of Compounds Inhibiting Very Early Events in the Cytomegalovirus Replication Cycle and Characterization of a Compound Identified Using the Assay

(2008) Y. Fukui et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Modulation of Oncogenic Phenotype in Human Glioma Cells by Cytomegalovirus IE1-Mediated Mitogenicity

(2008) C. S. Cobbs et al.   CANCER RESEARCH

Artesunate as a Potent Antiviral Agent in a Patient with Late Drug‐Resistant Cytomegalovirus Infection after Hematopoietic Stem Cell Transplantation

(2008) Michael Y. Shapira et al.   CLINICAL INFECTIOUS DISEASES

The Antiviral Activities of Artemisinin and Artesunate

(2008) Thomas Efferth et al.   CLINICAL INFECTIOUS DISEASES

New cell-based indicator assays for the detection of human cytomegalovirus infection and screening of inhibitors of viral immediate-early 2 protein activity

(2008) A. Luganini et al.   JOURNAL OF APPLIED MICROBIOLOGY

Dynamic Histone H3 Acetylation and Methylation at Human Cytomegalovirus Promoters during Replication in Fibroblasts

(2008) C. Cuevas-Bennett et al.   JOURNAL OF VIROLOGY

Establishment of Murine Cytomegalovirus Latency In Vivo Is Associated with Changes in Histone Modifications and Recruitment of Transcriptional Repressors to the Major Immediate-Early Promoter

(2008) X.-f. Liu et al.   JOURNAL OF VIROLOGY

Binding STAT2 by the Acidic Domain of Human Cytomegalovirus IE1 Promotes Viral Growth and Is Negatively Regulated by SUMO

(2008) Y. H. Huh et al.   JOURNAL OF VIROLOGY

Development of Cell Lines That Provide Tightly Controlled Temporal Translation of the Human Cytomegalovirus IE2 Proteins for Complementation and Functional Analyses of Growth-Impaired and Nonviable IE2 Mutant Viruses

(2008) R. L. Sanders et al.   JOURNAL OF VIROLOGY

Temporal Dynamics of Cytomegalovirus Chromatin Assembly in Productively Infected Human Cells

(2008) A. Nitzsche et al.   JOURNAL OF VIROLOGY

Phenotypes of major immediate-early gene mutants of mouse cytomegalovirus

(2008) Andreas Busche et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Platelet-derived growth factor-α receptor activation is required for human cytomegalovirus infection

(2008) Liliana Soroceanu et al.   NATURE

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway

(2008) Nicholas J. Buchkovich et al.   NATURE REVIEWS MICROBIOLOGY

Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: Implications for latency

(2008) E. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA