Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions for Medical Translation that Survived the “Test of Time”

Cytomegalovirus: Shape-Shifting the Immune System

(2018) Gaëlle Picarda et al.   JOURNAL OF IMMUNOLOGY

The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose

(2018) Anke Redeker et al.   Frontiers in Immunology

Control of primary mouse cytomegalovirus infection in lung nodular inflammatory foci by cooperation of interferon-gamma expressing CD4 and CD8 T cells

(2018) Yvonne Lueder et al.   PLoS Pathogens

Spatial and temporal coordination of antiviral responses by group 1 ILCs

(2018) Nicholas M. Adams et al.   IMMUNOLOGICAL REVIEWS

Immune responses to congenital cytomegalovirus infection

(2017) Ilija Brizić et al.   MICROBES AND INFECTION

Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections

(2017) Hannah L Itell et al.   Current Opinion in Virology

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

(2016) Stephan Halle et al.   IMMUNITY

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Refining human T-cell immunotherapy of cytomegalovirus disease: a mouse model with ‘humanized’ antigen presentation as a new preclinical study tool

(2016) Niels A. W. Lemmermann et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Mutual Interference between Cytomegalovirus and Reconstitution of Protective Immunity after Hematopoietic Cell Transplantation

(2016) Matthias J. Reddehase   Frontiers in Immunology

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance

(2016) Rafaela Holtappels et al.   Frontiers in Immunology

Mast cells: innate attractors recruiting protective CD8 T cells to sites of cytomegalovirus infection

(2015) Jürgen Podlech et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Stepwise adaptation of murine cytomegalovirus to cells of a foreign host for identification of host range determinants

(2015) Eleonore Ostermann et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Margaret Gladys Smith, mother of cytomegalovirus: 60th anniversary of cytomegalovirus isolation

(2015) Matthias J. Reddehase   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

The proteome of human cytomegalovirus virions and dense bodies is conserved across different strains

(2015) Nicole Büscher et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

How understanding immunology contributes to managing CMV disease in immunosuppressed patients: now and in future

(2015) J.G. Patrick Sissons et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Human cytomegalovirus: taking the strain

(2015) Gavin W. G. Wilkinson et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Limits and patterns of cytomegalovirus genomic diversity in humans

(2015) Nicholas Renzette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Humanized mouse models of human cytomegalovirus infection

(2015) Lindsey B Crawford et al.   Current Opinion in Virology

γδ T Cells Confer Protection against Murine Cytomegalovirus (MCMV)

(2015) Camille Khairallah et al.   PLoS Pathogens

Control of Murine Cytomegalovirus Infection by γδ T Cells

(2015) Sabrina Sell et al.   PLoS Pathogens

Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread

(2015) Niels A. W. Lemmermann et al.   PLoS Pathogens

Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice

(2015) Simone Thomas et al.   PLoS Pathogens

Lowest numbers of primary CD8+ T cells can reconstitute protective immunity upon adoptive immunotherapy

(2014) C. Stemberger et al.   BLOOD

Cytomegalovirus Hijacks CX3CR1hi Patrolling Monocytes as Immune-Privileged Vehicles for Dissemination in Mice

(2014) Lisa P. Daley-Bauer et al.   Cell Host & Microbe

Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model

(2014) Irena Slavuljica et al.   Cellular & Molecular Immunology

Clinical-scale isolation of ‘minimally manipulated’ cytomegalovirus-specific donor lymphocytes for the treatment of refractory cytomegalovirus disease

(2014) Marcus Odendahl et al.   CYTOTHERAPY

Using the Nonhuman Primate Model of HCMV to Guide Vaccine Development

(2014) Jesse Deere et al.   Viruses-Basel

Human cytomegalovirus intrahost evolution—a new avenue for understanding and controlling herpesvirus infections

(2014) Nicholas Renzette et al.   Current Opinion in Virology

Mast Cells Expedite Control of Pulmonary Murine Cytomegalovirus Infection by Enhancing the Recruitment of Protective CD8 T Cells to the Lungs

(2014) Stefan Ebert et al.   PLoS Pathogens

Adoptive transfer of cytomegalovirus-specific effector CD4+T cells provides antiviral protection from murine CMV infection

(2013) Sanja Mandaric Jeitziner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TCR-Ligand koff Rate Correlates with the Protective Capacity of Antigen-Specific CD8+ T Cells for Adoptive Transfer

(2013) M. Nauerth et al.   Science Translational Medicine

The p36 Isoform of Murine Cytomegalovirus m152 Protein Suffices for Mediating Innate and Adaptive Immune Evasion

(2013) Annette Fink et al.   Viruses-Basel

Epigenetic Control of Cytomegalovirus Latency and Reactivation

(2013) Xue-feng Liu et al.   Viruses-Basel

Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection

(2013) Nicholas Renzette et al.   PLoS Genetics

The Viral Chemokine MCK-2 of Murine Cytomegalovirus Promotes Infection as Part of a gH/gL/MCK-2 Complex

(2013) Felicia M. Wagner et al.   PLoS Pathogens

Nodular Inflammatory Foci Are Sites of T Cell Priming and Control of Murine Cytomegalovirus Infection in the Neonatal Lung

(2013) Felix R. Stahl et al.   PLoS Pathogens

Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection

(2012) Stefan Ebert et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Nucleocytoplasmic shuttling and CRM1-dependent MHC class I peptide presentation of human cytomegalovirus pp65

(2012) Nadine Frankenberg et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Viral latency drives ‘memory inflation’: a unifying hypothesis linking two hallmarks of cytomegalovirus infection

(2012) Christof K. Seckert et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Immune control in the absence of immunodominant epitopes: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells

(2012) Stefan Ebert et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Memory T cell inflation: understanding cause and effect

(2012) Geraldine A. O’Hara et al.   TRENDS IN IMMUNOLOGY

Buffered memory: a hypothesis for the maintenance of functional, virus-specific CD8+ T cells during cytomegalovirus infection

(2011) Christopher M. Snyder   IMMUNOLOGIC RESEARCH

Virus Progeny of Murine Cytomegalovirus Bacterial Artificial Chromosome pSM3fr Show Reduced Growth in Salivary Glands due to a Fixed Mutation of MCK-2

(2011) S. Jordan et al.   JOURNAL OF VIROLOGY

Shedding Light on the Elusive Role of Endothelial Cells in Cytomegalovirus Dissemination

(2011) Torsten Sacher et al.   PLoS Pathogens

Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation

(2010) T. Feuchtinger et al.   BLOOD

Granulocyte-Colony Stimulating Factor Reactivates Human Cytomegalovirus in a Latently Infected Humanized Mouse Model

(2010) M. Shane Smith et al.   Cell Host & Microbe

Reverse Genetics Modification of Cytomegalovirus Antigenicity and Immunogenicity by CD8 T-Cell Epitope Deletion and Insertion

(2010) Niels A. W. Lemmermann et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus

(2010) S. G. Hansen et al.   SCIENCE

Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation

(2010) Anita Schmitt et al.   TRANSFUSION

Liver Sinusoidal Endothelial Cells Are a Site of Murine Cytomegalovirus Latency and Reactivation

(2009) C. K. Seckert et al.   JOURNAL OF VIROLOGY

The Major Virus-Producing Cell Type during Murine Cytomegalovirus Infection, the Hepatocyte, Is Not the Source of Virus Dissemination in the Host

(2008) Torsten Sacher et al.   Cell Host & Microbe

Subdominant CD8 T-Cell Epitopes Account for Protection against Cytomegalovirus Independent of Immunodomination

(2008) R. Holtappels et al.   JOURNAL OF VIROLOGY

Epitope-specific in vivo protection against cytomegalovirus disease by CD8 T cells in the murine model of preemptive immunotherapy

(2008) Verena Böhm et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

CD8 T-cell-based immunotherapy of cytomegalovirus infection: “proof of concept” provided by the murine model

(2008) Rafaela Holtappels et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Rhesus CMV: an emerging animal model for human CMV

(2008) Colin Powers et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Evaluation of recombinant modified vaccinia Ankara virus-based rhesus cytomegalovirus vaccines in rhesus macaques

(2008) Yujuan Yue et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

MHC class I immune evasion in MCMV infection

(2008) Carmen M. Doom et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Hematopoietic stem cell transplantation with latently infected donors does not transmit virus to immunocompromised recipients in the murine model of cytomegalovirus infection

(2008) Christof K. Seckert et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation

(2007) V. H. Nguyen et al.   BLOOD