cAMP and Epac in the regulation of tissue fibrosis

Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger

(2011) P. A. Insel et al.   Acta Physiologica

Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts

(2011) Camila Leindecker Stumm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanisms of Resolution of Inflammation

(2011) Benjamin H. Maskrey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

(2011) Clint L. Miller et al.   BASIC RESEARCH IN CARDIOLOGY

Anti-fibrogenic strategies and the regression of fibrosis

(2011) Tatiana Kisseleva et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

GPCR expression in tissues and cells: Are the optimal receptors being used as drug targets?

(2011) PA Insel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Matrix control of scarring

(2011) Cecelia C. Yates et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA

(2011) Lingzhi Zhang et al.   CELLULAR SIGNALLING

Mechanisms of fibrosis: the role of the pericyte

(2011) Claudia Schrimpf et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

The role of cell plasticity in progression and reversal of renal fibrosis

(2011) Jean-Claude Dussaule et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Fibroblasts and myofibroblasts in renal fibrosis

(2011) Soma Meran et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Plasmin Overcomes Resistance to Prostaglandin E2in Fibrotic Lung Fibroblasts by Reorganizing Protein Kinase A Signaling

(2011) Katsuhide Okunishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G Protein-coupled Receptor Kinase-2 Is a Novel Regulator of Collagen Synthesis in Adult Human Cardiac Fibroblasts

(2011) Karen M. D'Souza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

(2011) Wilhelm Kriz et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Epac-Rap Signaling Reduces Cellular Stress and Ischemia-induced Kidney Failure

(2011) G. Stokman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Scar wars: mapping the fate of epithelial–mesenchymal–myofibroblast transition

(2011) Susan E. Quaggin et al.   KIDNEY INTERNATIONAL

Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome

(2011) S.L. Mironov et al.   NEUROPHARMACOLOGY

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

(2010) Charles N. Serhan   AMERICAN JOURNAL OF PATHOLOGY

Fibroblast-specific expression of AC6 enhances β-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis

(2010) Xiaoqiu Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): From cancer stem cells to aging-associated fibrosis

(2010) Sílvia Cufí et al.   CELL CYCLE

Smaddening Complexity: The Role of Smad3 in Epithelial-Myofibroblast Transition

(2010) András Masszi et al.   CELLS TISSUES ORGANS

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

Pirfenidone: an anti-fibrotic therapy for progressive kidney disease

(2010) Monique E Cho et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The role of inflammatory and fibrogenic pathways in heart failure associated with aging

(2010) Wei Chen et al.   HEART FAILURE REVIEWS

Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3

(2010) András Masszi et al.   JOURNAL OF CELL BIOLOGY

The origin of fibroblasts and mechanism of cardiac fibrosis

(2010) Guido Krenning et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice

(2010) Kristy A. Bauman et al.   JOURNAL OF CLINICAL INVESTIGATION

Prostacyclin receptor suppresses cardiac fibrosis: Role of CREB phosphorylation

(2010) Elsa C. Chan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

FMNL2 Enhances Invasion of Colorectal Carcinoma by Inducing Epithelial-Mesenchymal Transition

(2010) Y. Li et al.   MOLECULAR CANCER RESEARCH

Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

(2010) C. H. Osterreicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Update on the pathophysiology of liver fibrosis

(2010) Massimo Pinzani et al.   Expert Review of Gastroenterology & Hepatology

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-β1-stimulated fibroblasts

(2009) Shinsaku Togo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Critical Role of Serum Response Factor in Pulmonary Myofibroblast Differentiation Induced by TGF-β

(2009) Nathan Sandbo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function

(2009) Maria Grandoch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Elevation of intracellular cyclic AMP inhibits NF-κB-mediated thymosin β4 expression in melanoma cells

(2009) Aeyung Kim et al.   EXPERIMENTAL CELL RESEARCH

Prostaglandin E2 induces fibroblast apoptosis by modulating multiple survival pathways

(2009) Steven K. Huang et al.   FASEB JOURNAL

Procaterol Inhibits Lung Fibroblast Migration

(2009) Tadashi Kohyama et al.   INFLAMMATION

The myofibroblast: Paradigm for a mechanically active cell

(2009) Boris Hinz   JOURNAL OF BIOMECHANICS

Expression and Activity of Phosphodiesterase Isoforms during Epithelial Mesenchymal Transition: The Role of Phosphodiesterase 4

(2009) Ewa Kolosionek et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of Serine 11 and Serine 92 as New Positive Regulators of Human Snail1 Function: Potential Involvement of Casein Kinase-2 and the cAMP-activated Kinase Protein Kinase A

(2009) Matthew Reid MacPherson et al.   MOLECULAR BIOLOGY OF THE CELL

Prostaglandin E2 differentially regulates contraction and structural reorganization of anchored collagen gels by human adult and fetal dermal fibroblasts

(2009) Aron Parekh et al.   WOUND REPAIR AND REGENERATION

Experimental Therapies in Hypertrophic Cardiomyopathy

(2009) Ali J. Marian   Journal of Cardiovascular Translational Research

Regulation of transforming growth factor β-induced responses by protein kinase A in pancreatic acinar cells

(2008) Huibin Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prostaglandin E2Inhibits Specific Lung Fibroblast Functions via Selective Actions of PKA and Epac-1

(2008) Steven K. Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

(2008) U. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

(2007) George G. Holz et al.   CELLULAR SIGNALLING