Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3

Adenosine A2A receptors promote collagen production by a Fli1- and CTGF-mediated mechanism

(2013) Edwin SL Chan et al.   ARTHRITIS RESEARCH & THERAPY

cAMP and Epac in the regulation of tissue fibrosis

(2012) Paul A Insel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacological blockade of adenosine A2A receptors diminishes scarring

(2012) Miguel Perez-Aso et al.   FASEB JOURNAL

Plasmin Overcomes Resistance to Prostaglandin E2in Fibrotic Lung Fibroblasts by Reorganizing Protein Kinase A Signaling

(2011) Katsuhide Okunishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G Protein-coupled Receptor Kinase-2 Is a Novel Regulator of Collagen Synthesis in Adult Human Cardiac Fibroblasts

(2011) Karen M. D'Souza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine A2A receptor activation stimulates collagen production in sclerodermic dermal fibroblasts either directly and through a cross-talk with the cannabinoid system

(2011) Pietro Enea Lazzerini et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Anti-Inflammatory and Immunosuppressive Effects of the A2AAdenosine Receptor

(2011) Gillian R. Milne et al.   TheScientificWorldJOURNAL

Cyclic AMP Suppresses Matrix Metalloproteinase-1 Expression through Inhibition of MAPK and GSK-3β

(2010) Chi-Hyun Park et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts

(2010) Laurence Goffin et al.   ARTHRITIS RESEARCH & THERAPY

Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K

(2009) Francisco Villarreal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Increased cAMP Levels Modulate Transforming Growth Factor-β/Smad-induced Expression of Extracellular Matrix Components and Other Key Fibroblast Effector Functions

(2009) Meinhard Schiller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments

(2009) A. Ohta et al.   JOURNAL OF IMMUNOLOGY

Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues

(2009) A. Lipshtat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological Blockade of A2A Receptors Prevents Dermal Fibrosis in a Model of Elevated Tissue Adenosine

(2008) Patricia Fernández et al.   AMERICAN JOURNAL OF PATHOLOGY

Prostaglandin E2Inhibits Specific Lung Fibroblast Functions via Selective Actions of PKA and Epac-1

(2008) Steven K. Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ecto-5′-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis

(2008) Zhongsheng Peng et al.   FASEB JOURNAL

Adenosine A2A Receptor Blockade or Deletion Diminishes Fibrocyte Accumulation in the Skin in a Murine Model of Scleroderma, Bleomycin-induced Fibrosis

(2008) Majid Katebi et al.   INFLAMMATION

Akt Blockade Downregulates Collagen and Upregulates MMP1 in Human Dermal Fibroblasts

(2008) Andreea M. Bujor et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

(2008) U. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA