Platelets and Extracellular Traps in Infections

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

(2019) Sebastian Boeltz et al.   CELL DEATH AND DIFFERENTIATION

Neutrophil Extracellular Traps Enhance Staphylococcus Aureus Vegetation Formation through Interaction with Platelets in Infective Endocarditis

(2019) Chih-Chieh Hsu et al.   THROMBOSIS AND HAEMOSTASIS

Neutrophils and NETS in modulating acute and chronic inflammation

(2019) Fernanda Vargas e Silva Castanheira et al.   BLOOD

Combination therapy targeting platelet activation and virus replication protects mice against lethal influenza pneumonia

(2019) Sivasami Pulavendran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Neutrophil’s Role During Health and Disease

(2019) Pei Xiong Liew et al.   PHYSIOLOGICAL REVIEWS

The role of platelets in mediating a response to human influenza infection

(2019) Milka Koupenova et al.   Nature Communications

The Healthy Human Blood Microbiome: Fact or Fiction?

(2019) Diego J. Castillo et al.   Frontiers in Cellular and Infection Microbiology

The Innate Part of the Adaptive Immune System

(2019) Sophie Hillion et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Extracellular DNA traps in inflammation, injury and healing

(2019) Christoph Daniel et al.   Nature Reviews Nephrology

Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2

(2019) Pei-Shan Sung et al.   Nature Communications

Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice

(2019) Agostina Carestia et al.   Cell Reports

Platelet Inflammatory Response to Stress

(2019) Fabrice Cognasse et al.   Frontiers in Immunology

Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis by eosinophil extracellular traps

(2019) Charlotte Marx et al.   BLOOD

Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells

(2019) Beatrice Lazzaretto et al.   JOURNAL OF IMMUNOLOGY

The Role of Extracellular Histones in Influenza Virus Pathogenesis

(2018) Harshini K. Ashar et al.   AMERICAN JOURNAL OF PATHOLOGY

Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histones

(2018) Omar Elaskalani et al.   Cell Communication and Signaling

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

(2018) Milka Koupenova et al.   CIRCULATION RESEARCH

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

(2018) Gabriel Sollberger et al.   DEVELOPMENTAL CELL

The biology of the platelet with special reference to inflammation wound healing and immunity

(2018) Alan T Nurden   Frontiers in Bioscience-Landmark

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(2018)   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Relative antibacterial functions of complement and NETs: NETs trap and complement effectively kills bacteria

(2018) Louiza Azzouz et al.   MOLECULAR IMMUNOLOGY

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

(2018) Koshu Okubo et al.   NATURE MEDICINE

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation

(2018) Joachim Pircher et al.   Nature Communications

ETosis-derived DNA trap production in middle ear effusion is a common feature of eosinophilic otitis media

(2018) Nobuo Ohta et al.   ALLERGOLOGY INTERNATIONAL

Circulating H3Cit is elevated in a human model of endotoxemia and can be detected bound to microvesicles

(2018) Sofie Paues Göranson et al.   Scientific Reports

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates

(2018) Ranjit Sivanandham et al.   JOURNAL OF CLINICAL INVESTIGATION

Platelet biology and functions: new concepts and clinical perspectives

(2018) Paola E. J. van der Meijden et al.   Nature Reviews Cardiology

Eosinophil Extracellular Traps and Inflammatory Pathologies—Untangling the Web!

(2018) Manali Mukherjee et al.   Frontiers in Immunology

Platelet toll-like receptors in thromboinflammation

(2017) Mirta Schattner   Frontiers in Bioscience-Landmark

Neither eosinophils nor neutrophils require ATG5-dependent autophagy for extracellular DNA trap formation

(2017) Nina Germic et al.   IMMUNOLOGY

Macrophage Extracellular Traps: A Scoping Review

(2017) Ryan S. Doster et al.   Journal of Innate Immunity

DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

(2017) Nirit Mor-Vaknin et al.   Nature Communications

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

A novel method for high-throughput detection and quantification of neutrophil extracellular traps reveals ROS-independent NET release with immune complexes

(2016) Tineke Kraaij et al.   AUTOIMMUNITY REVIEWS

The role of leukocytes in thrombosis

(2016) Laura L. Swystun et al.   BLOOD

Extracellular histones reduce survival and angiogenic responses of late outgrowth progenitor and mature endothelial cells

(2016) H. A. Mena et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Role of platelets in neutrophil extracellular trap (NET) production and tissue injury

(2016) Seok-Joo Kim et al.   SEMINARS IN IMMUNOLOGY

Neutrophils Discriminate between Lipopolysaccharides of Different Bacterial Sources and Selectively Release Neutrophil Extracellular Traps

(2016) Elmar Pieterse et al.   Frontiers in Immunology

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(2016)   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

P-selectin promotes neutrophil extracellular trap formation in mice

(2015) J. Etulain et al.   BLOOD

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

Human platelets and their capacity of binding viruses: meaning and challenges?

(2015) Adrien Chabert et al.   BMC IMMUNOLOGY

Platelets in leucocyte recruitment and function

(2015) Jan Rossaint et al.   CARDIOVASCULAR RESEARCH

Neutrophil extracellular traps can activate alternative complement pathways

(2015) H. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction

(2015) Dimitrios A. Stakos et al.   EUROPEAN HEART JOURNAL

Arginine-rich histones have strong antiviral activity for influenza A viruses

(2015) Marloes Hoeksema et al.   Innate Immunity

Dengue Virus Serotype-2 Interferes with the Formation of Neutrophil Extracellular Traps

(2015) Maria Maximina B. Moreno-Altamirano et al.   INTERVIROLOGY

Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets

(2015) Agostina Carestia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease

(2015) Bart Cortjens et al.   JOURNAL OF PATHOLOGY

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(2015)   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet secretory behaviour: as diverse as the granules … or not?

(2015) H. Heijnen et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

(2015) David Nobuhiro Douda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Classical ROS-dependent and early/rapid ROS-independent release of Neutrophil Extracellular Traps triggered by Leishmania parasites

(2015) Natalia C. Rochael et al.   Scientific Reports

Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis

(2014) M. Koupenova et al.   BLOOD

β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps

(2014) Martin J. Raftery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells

(2014) F. Semeraro et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

In Vivo Characterization of Neutrophil Extracellular Traps in Various Organs of a Murine Sepsis Model

(2014) Koji Tanaka et al.   PLoS One

Neutrophils scan for activated platelets to initiate inflammation

(2014) Vinatha Sreeramkumar et al.   SCIENCE

Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation

(2013) Yasuyuki Arai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

(2013) E. D. Hottz et al.   BLOOD

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

(2013) S. Ueki et al.   BLOOD

Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation

(2013) J. Rossaint et al.   BLOOD

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Macrophage Clearance of Neutrophil Extracellular Traps Is a Silent Process

(2013) C. Farrera et al.   JOURNAL OF IMMUNOLOGY

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

Complement C5 Activation during Influenza A Infection in Mice Contributes to Neutrophil Recruitment and Lung Injury

(2013) Cristiana C. Garcia et al.   PLoS One

Functional responses and molecular mechanisms involved in histone-mediated platelet activation

(2013) Marìa Albertina Romaniuk et al.   THROMBOSIS AND HAEMOSTASIS

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

T granules in human platelets function in TLR9 organization and signaling

(2012) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Bonding the foe – NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals

(2012) Christine Schorn et al.   Frontiers in Immunology

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

P2Y6 Receptor Signaling Pathway Mediates Inflammatory Responses Induced by Monosodium Urate Crystals

(2011) H. Uratsuji et al.   JOURNAL OF IMMUNOLOGY

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation

(2011) C. T. AMMOLLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

(2011) Ioannis Mitroulis et al.   PLoS One

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Junín Virus Infection of Human Hematopoietic Progenitors Impairs In Vitro Proplatelet Formation and Platelet Release via a Bystander Effect Involving Type I IFN Signaling

(2010) Roberto G. Pozner et al.   PLoS Pathogens

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

(2008) M. von Kockritz-Blickwede et al.   BLOOD

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE