Circulating H3Cit is elevated in a human model of endotoxemia and can be detected bound to microvesicles

Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients

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Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer

(2018) Charlotte Thålin et al.   PLoS One

Neutrophil Activation During Septic Shock

(2018) Laure Stiel et al.   SHOCK

Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma

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Neutrophil Extracellular Traps Promote Hypercoagulability in Patients With Sepsis

(2017) Shuofei Yang et al.   SHOCK

Evidence of Netosis in Septic Shock-Induced Disseminated Intravascular Coagulation

(2017) Xavier Delabranche et al.   SHOCK

CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock

(2017) Baihong Pan et al.   Scientific Reports

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

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(2016) Jeremy Stoller et al.   JOURNAL OF CRITICAL CARE

Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model

(2016) Bethany M. Biron et al.   Journal of Innate Immunity

Lipopolysaccharide Alters Motivated Behavior in a Monetary Reward Task: a Randomized Trial

(2016) Julie Lasselin et al.   NEUROPSYCHOPHARMACOLOGY

NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation

(2016) Charlotte Thålin et al.   THROMBOSIS RESEARCH

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

(2016) Paula Giselle Czaikoski et al.   PLoS One

Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in SepsisSignificance

(2015) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD40L expression in plasma of volunteers following LPS administration: A comparison between assay of CD40L on platelet microvesicles and soluble CD40L

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Presence of Neutrophil Extracellular Traps and Citrullinated Histone H3 in the Bloodstream of Critically Ill Patients

(2014) Tomoya Hirose et al.   PLoS One

Citrullinated histone H3: A novel target for the treatment of sepsis

(2014) Yongqing Li et al.   SURGERY

Thrombosis: tangled up in NETs

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Surviving Sepsis Campaign

(2013) R. Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy

(2013) Xavier Delabranche et al.   INTENSIVE CARE MEDICINE

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Lipopolysaccharide Administration on the Number, Phenotype and Content of Nuclear Molecules in Blood Microparticles of Normal Human Subjects

(2013) A. Soop et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Circulating nucleosomes as a predictor of sepsis and organ dysfunction in critically ill patients

(2012) QiXing Chen et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Nationwide Trends of Severe Sepsis in the 21st Century (2000–2007)

(2011) Gagan Kumar et al.   CHEST

Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock

(2011) Yongqing Li et al.   SURGERY

Microparticles

(2010) Sebastian F. Mause et al.   CIRCULATION RESEARCH

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

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(2008) Stefan Margraf et al.   SHOCK

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE