Platelet secretory behaviour: as diverse as the granules … or not?

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

(2015) Jiajie Diao et al.   NATURE

Dissection of autophagy in human platelets

(2014) Wenfeng Feng et al.   Autophagy

Quantitative proteomics analysis reveals similar release profiles following specific PAR-1 or PAR-4 stimulation of platelets

(2014) Thijs C. van Holten et al.   CARDIOVASCULAR RESEARCH

FLow-Induced PRotrusions (FLIPRs)

(2014) Claudia Tersteeg et al.   CIRCULATION RESEARCH

Platelet secretion and hemostasis require syntaxin-binding protein STXBP5

(2014) Shaojing Ye et al.   JOURNAL OF CLINICAL INVESTIGATION

Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion

(2014) Qiuyu Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Platelets guide the formation of early metastatic niches

(2014) M. Labelle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets

(2013) F. Pertuy et al.   BLOOD

I B kinase phosphorylation of SNAP-23 controls platelet secretion

(2013) Z. A. Karim et al.   BLOOD

Platelets as Cellular Effectors of Inflammation in Vascular Diseases

(2013) Matthew T. Rondina et al.   CIRCULATION RESEARCH

Lysosome-related organelles: unusual compartments become mainstream

(2013) Michael S Marks et al.   CURRENT OPINION IN CELL BIOLOGY

The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story

(2013) T. Nightingale et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11

(2012) F. E. Sepulveda et al.   BLOOD

SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models

(2012) R. Meng et al.   BLOOD

Granule exocytosis is required for platelet spreading: differential sorting of  -granules expressing VAMP-7

(2012) C. G. Peters et al.   BLOOD

Platelet secretion is kinetically heterogeneous in an agonist-responsive manner

(2012) D. Jonnalagadda et al.   BLOOD

T granules in human platelets function in TLR9 organization and signaling

(2012) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Synaptotagmin-like protein 4 and Rab8 interact and increase dense granule release in platelets

(2012) A. HAMPSON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells

(2012) Manuel Gálvez-Santisteban et al.   NATURE CELL BIOLOGY

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

Quantitative immunofluorescence mapping reveals little functional coclustering of proteins within platelet  -granules

(2011) J. Kamykowski et al.   BLOOD

The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane

(2011) E. D. Elstak et al.   BLOOD

Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli

(2011) M. Chatterjee et al.   BLOOD

Cytoskeletal F-actin, not the circumferential coil of microtubules, regulates platelet dense-body granule secretion

(2011) Shencheng Ge et al.   PLATELETS

Syntaxin 11 Binds Vti1b and Regulates Late Endosome to Lysosome Fusion in Macrophages

(2011) Carolin Offenhäuser et al.   TRAFFIC

Dynamic Conformational Changes in MUNC18 Prevent Syntaxin Binding

(2011) Dana Bar-On et al.   PLoS Computational Biology

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis

(2010) Q. Ren et al.   BLOOD

Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis

(2010) N. L. Smith et al.   BLOOD

The platelet interior revisited: electron tomography reveals tubular  -granule subtypes

(2010) H. van Nispen tot Pannerden et al.   BLOOD

Multigranular exocytosis of Weibel-Palade bodies in vascular endothelial cells

(2010) K. M. Valentijn et al.   BLOOD

Effect of Genetic Variations in Syntaxin-Binding Protein-5 and Syntaxin-2 on von Willebrand Factor Concentration and Cardiovascular Risk

(2010) Janine E. van Loon et al.   Circulation-Cardiovascular Genetics

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

(2010) Ok-Ho Shin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets

(2009) O. Neumuller et al.   BLOOD

Platelet protein disulfide isomerase is localized in the dense tubular system and does not become surface expressed after activation

(2009) H. E. van Nispen tot Pannerden et al.   BLOOD

Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo

(2009) G. J. Graham et al.   BLOOD

Granules and thrombus formation

(2009) W. H. A. Kahr   BLOOD

Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells

(2009) T. D. Nightingale et al.   BLOOD

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

(2009) Marjorie Côte et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein synthesis by platelets: historical and new perspectives

(2009) A. S. WEYRICH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mechanisms of regulated unconventional protein secretion

(2009) Walter Nickel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Friends and foes in synaptic transmission: the role of tomosyn in vesicle priming

(2009) Uri Ashery et al.   TRENDS IN NEUROSCIENCES

VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways

(2008) N. Tiwari et al.   BLOOD

Platelets actively sequester angiogenesis regulators

(2008) G. Lakka Klement et al.   BLOOD

Phosphorylation of SNAP-23 by IκB Kinase 2 Regulates Mast Cell Degranulation

(2008) Kotaro Suzuki et al.   CELL

The platelet release reaction: just when you thought platelet secretion was simple

(2008) Qiansheng Ren et al.   CURRENT OPINION IN HEMATOLOGY

Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release

(2008) Toshiaki Sakisaka et al.   JOURNAL OF CELL BIOLOGY