Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease
出版年份 2020 全文链接
标题
Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease
作者
关键词
-
出版物
PHARMACOLOGICAL REVIEWS
Volume 72, Issue 2, Pages 466-485
出版商
American Society for Pharmacology & Experimental Therapeutics (ASPET)
发表日期
2020-03-07
DOI
10.1124/pr.119.018762
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells
- (2019) Xiaowen Guan et al. AAPS Journal
- Ethanol Activates Immune Response In Lymphoblastoid Cells
- (2019) Jeanette N. McClintick et al. ALCOHOL
- The Monocarboxylate Transporter SLC16A6 Regulates Adult Length in Zebrafish and Is Associated With Height in Humans
- (2019) Santhosh Karanth et al. Frontiers in Physiology
- Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes
- (2019) Yongxu Zhao et al. Cell Reports
- Shared genes between Alzheimer’s disease and ischemic stroke
- (2019) Chang-Juan Wei et al. CNS Neuroscience & Therapeutics
- A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells
- (2019) Mam Y. Mboge et al. BIOCHEMICAL JOURNAL
- Catalytically‐inactive carbonic anhydrase‐related proteins enhance transport of lactate by MCT 1
- (2019) Ashok Aspatwar et al. FEBS Open Bio
- Dynamic bioenergetic alterations in colorectal adenomatous polyps and adenocarcinomas
- (2019) Wey-Ran Lin et al. EBioMedicine
- TNFα-Induced Expression of Transport Protein Genes in HUVEC Cells Is Associated with Enhanced Expression of Transcription Factor Genes RELB and NFKB2 of the Non-Canonical NF-κB Pathway
- (2018) E. N. Knyazev et al. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
- Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy
- (2018) Pascale Fisel et al. CTS-Clinical and Translational Science
- Genetic variations in the monocarboxylate transporter genes ( SLC16A1 , SLC16A3 , and SLC16A11 ) in the Japanese population
- (2018) Yuki Kimura et al. Drug Metabolism and Pharmacokinetics
- An unexpected world population variation of MCT1 polymorphism 1470T > A involved in lactate transport
- (2018) Federico Onali et al. European Journal of Sport Science
- The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease
- (2018) Jiaqi Liu et al. HUMAN GENETICS
- The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells
- (2018) Samantha Ames et al. Oncotarget
- Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10)
- (2018) David S. Sharlin et al. Scientific Reports
- A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells
- (2018) Sina Ibne Noor et al. eLife
- Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants
- (2018) Bianca D. van Groen et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Dysregulation of mucosal membrane transporters and drug metabolizing enzymes in ulcerative colitis
- (2018) Pascal Erdmann et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer
- (2018) Sara Bisetto et al. Frontiers in Oncology
- Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70
- (2018) Linda S. Forero-Quintero et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019
- (2018) Annalisa Buniello et al. NUCLEIC ACIDS RESEARCH
- Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice
- (2017) Benjamin Chatel et al. FASEB JOURNAL
- Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma
- (2017) Richard A. Noble et al. HAEMATOLOGICA
- Abnormal creatine transport of mutations in monocarboxylate transporter 12 (MCT12) found in patients with age-related cataract can be partially rescued by exogenous chaperone CD147
- (2017) Andrina Stäubli et al. HUMAN MOLECULAR GENETICS
- Clinical and Molecular Characteristics of SLC16A2 (MCT8) Mutations in Three Families with the Allan-Herndon-Dudley Syndrome
- (2017) Francesca Novara et al. HUMAN MUTATION
- Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking
- (2017) Jieyun Cao et al. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
- Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6
- (2017) Robert S. Jones et al. MOLECULAR PHARMACEUTICS
- Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain
- (2017) Kerstin Römermann et al. NEUROPHARMACOLOGY
- Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells
- (2017) K Diehl et al. ONCOGENE
- Associations of common variants in the SLC16A11 , TCF7L2, and ABCA1 genes with pediatric-onset type 2 diabetes and related glycemic traits in families: A case-control and case-parent trio study
- (2017) América L Miranda-Lora et al. PEDIATRIC DIABETES
- RNA-Seq analysis of peripheral blood mononuclear cells reveals unique transcriptional signatures associated with disease progression in dengue patients
- (2017) Arup Banerjee et al. Translational Research
- MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis
- (2017) Wanfu Xu et al. Cell Death & Disease
- Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity
- (2017) Nicola J. Curtis et al. Oncotarget
- Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma
- (2017) Richard A. Noble et al. HAEMATOLOGICA
- Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer
- (2017) Britt I. Drögemöller et al. JAMA Oncology
- The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters
- (2016) B. Nancolas et al. BIOCHEMICAL JOURNAL
- Monocarboxylate transporters in the brain and in cancer
- (2016) Jhudit Pérez-Escuredo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney
- (2016) Sahar Roshanbin et al. BMC NEUROSCIENCE
- Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease
- (2016) RS Jones et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- MCT8 Deficiency in Male Mice Mitigates the Phenotypic Abnormalities Associated With the Absence of a Functional Type 3 Deiodinase
- (2016) J. Patrizia Stohn et al. ENDOCRINOLOGY
- Integration of a ‘proton antenna’ facilitates transport activity of the monocarboxylate transporter MCT4
- (2016) Sina Ibne Noor et al. FEBS Journal
- Few Amino Acid Exchanges Expand the Substrate Spectrum of Monocarboxylate Transporter 10*
- (2016) Jörg Johannes et al. MOLECULAR ENDOCRINOLOGY
- Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism
- (2016) Kyung Eun Kim et al. Scientific Reports
- Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics
- (2015) Miriam G. Mooij et al. CLINICAL PHARMACOKINETICS
- Embryonic stem cell-derived pancreatic endoderm transplant with MCT1-suppressing miR-495 attenuates type II diabetes in mice
- (2015) Dong Liang et al. ENDOCRINE JOURNAL
- Intestinal absorption mechanisms of MTBH, a novel hesperetin derivative, in Caco-2 cells, and potential involvement of monocarboxylate transporter 1 and multidrug resistance protein 2
- (2015) Chenlin Shen et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Analysis of the Binding Moiety Mediating the Interaction between Monocarboxylate Transporters and Carbonic Anhydrase II
- (2015) Sina Ibne Noor et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters
- (2015) Ibtissam Marchiq et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival
- (2015) Franziska Baenke et al. JOURNAL OF PATHOLOGY
- Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria
- (2015) N. Dhayat et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis
- (2015) Kuei-Yang Hsiao et al. MOLECULAR HUMAN REPRODUCTION
- MCT4 surpasses the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma
- (2015) Pascale Fisel et al. Oncotarget
- Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function
- (2015) Somayeh Jamali et al. Scientific Reports
- Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory
- (2015) Monika Tadi et al. PLoS One
- Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease
- (2014) April D. Lake et al. AMINO ACIDS
- High Monocarboxylate Transporter 4 Protein Expression in Stromal Cells Predicts Adverse Survival in Gastric Cancer
- (2014) Ping Yan et al. Asian Pacific Journal of Cancer Prevention
- Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia
- (2014) Chao Chen et al. BIPOLAR DISORDERS
- Role of Monocarboxylate Transporters in Drug Delivery to the Brain
- (2014) Nisha Vijay et al. CURRENT PHARMACEUTICAL DESIGN
- Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis
- (2014) Steffen Mayerl et al. JOURNAL OF CLINICAL INVESTIGATION
- Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
- (2013) J. R. Doherty et al. CANCER RESEARCH
- Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes
- (2013) Ana D. Martins et al. CELL AND TISSUE RESEARCH
- Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer
- (2013) R. Polanski et al. CLINICAL CANCER RESEARCH
- DNA Methylation of the SLC16A3 Promoter Regulates Expression of the Human Lactate Transporter MCT4 in Renal Cancer with Consequences for Clinical Outcome
- (2013) P. Fisel et al. CLINICAL CANCER RESEARCH
- Tissue-Specific Alterations in Thyroid Hormone Homeostasis in Combined Mct10 and Mct8 Deficiency
- (2013) Julia Müller et al. ENDOCRINOLOGY
- Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma
- (2013) Jena Hudson et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel
- (2013) Mine S. Cicek et al. HUMAN MOLECULAR GENETICS
- The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter
- (2013) Jeannette Abplanalp et al. HUMAN MOLECULAR GENETICS
- Intracellular and Extracellular Carbonic Anhydrases Cooperate Non-enzymatically to Enhance Activity of Monocarboxylate Transporters
- (2013) Michael Klier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of AMPK activation on monocarboxylate transporter (MCT)1 and MCT4 in denervated muscle
- (2013) Yu Kitaoka et al. Journal of Physiological Sciences
- Possible involvement of AMPK in acute exercise-induced expression of monocarboxylate transporters MCT1 and MCT4 mRNA in fast-twitch skeletal muscle
- (2013) Masaki Takimoto et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The SLC16 gene family – Structure, role and regulation in health and disease
- (2013) Andrew P. Halestrap MOLECULAR ASPECTS OF MEDICINE
- ATP5H/KCTD2 locus is associated with Alzheimer's disease risk
- (2013) M Boada et al. MOLECULAR PSYCHIATRY
- The Neuroplastin Adhesion Molecules Are Accessory Proteins That Chaperone the Monocarboxylate Transporter MCT2 to the Neuronal Cell Surface
- (2013) Marieangela C. Wilson et al. PLoS One
- Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice
- (2013) Sylvain Lengacher et al. PLoS One
- Thyroid hormone transporters and deiodinases in the developing human hypothalamus
- (2012) Edith C H Friesema et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting
- (2012) S. E. Hugo et al. GENES & DEVELOPMENT
- Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: The role of protein kinase C (PKC)
- (2012) Katsuya Narumi et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Role of monocarboxylate transporters in human cancers: state of the art
- (2012) Céline Pinheiro et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Endothelial Cell-Derived Nitric Oxide Enhances Aerobic Glycolysis in Astrocytes via HIF-1 -Mediated Target Gene Activation
- (2012) B. Brix et al. JOURNAL OF NEUROSCIENCE
- T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control
- (2012) Luca Mariotta et al. JOURNAL OF PHYSIOLOGY-LONDON
- Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women
- (2012) Rocío Cupeiro et al. JOURNAL OF SCIENCE AND MEDICINE IN SPORT
- Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions
- (2012) Kiminobu Sugito et al. PEDIATRIC BLOOD & CANCER
- Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer
- (2012) Nelma Pértega-Gomes et al. PROSTATE
- Effect of growth on monocarboxylate transporters and indicators of energy metabolism in the gluteus medius muscle of Thoroughbreds
- (2011) Yu Kitaoka et al. AMERICAN JOURNAL OF VETERINARY RESEARCH
- Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells culturedin vitro
- (2011) Luís Rato et al. BIOSCIENCE REPORTS
- Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments
- (2011) N. Draoui et al. Disease Models & Mechanisms
- The monocarboxylate transporter family-Structure and functional characterization
- (2011) Andrew P. Halestrap IUBMB LIFE
- The monocarboxylate transporter family-Role and regulation
- (2011) Andrew P. Halestrap et al. IUBMB LIFE
- Transport Activity of the High-affinity Monocarboxylate Transporter MCT2 Is Enhanced by Extracellular Carbonic Anhydrase IV but Not by Intracellular Carbonic Anhydrase II
- (2011) Michael Klier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Monocarboxylate Transporter 2 and Stroke Severity in a Rodent Model of Sleep Apnea
- (2011) Y. Wang et al. JOURNAL OF NEUROSCIENCE
- Quantitative Membrane Protein Expression at the Blood–Brain Barrier of Adult and Younger Cynomolgus Monkeys
- (2011) Katsuaki Ito et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Expression of monocarboxylate transporter (MCT) 1 and MCT4 in overloaded mice plantaris muscle
- (2011) Yu Kitaoka et al. Journal of Physiological Sciences
- miR-29a and miR-29b Contribute to Pancreatic -Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1)
- (2011) T. J. Pullen et al. MOLECULAR AND CELLULAR BIOLOGY
- Human metabolic individuality in biomedical and pharmaceutical research
- (2011) Karsten Suhre et al. NATURE
- The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein
- (2010) Matthew J. Ovens et al. BIOCHEMICAL JOURNAL
- Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44
- (2010) Céline Pinheiro et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion
- (2010) Caterina Di Cosmo et al. JOURNAL OF CLINICAL INVESTIGATION
- Nonenzymatic Augmentation of Lactate Transport via Monocarboxylate Transporter Isoform 4 by Carbonic Anhydrase II
- (2010) Holger M. Becker et al. JOURNAL OF MEMBRANE BIOLOGY
- AMP-activated protein kinase regulates the expression of monocarboxylate transporter 4 in skeletal muscle
- (2010) Ayako Furugen et al. LIFE SCIENCES
- Monocarboxylate transporter 1 and CD147 are up-regulated by natural and synthetic peroxisome proliferator-activated receptor α agonists in livers of rodents and pigs
- (2010) Bettina König et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Basolateral Sorting Signals Regulating Tissue-Specific Polarity of Heteromeric Monocarboxylate Transporters in Epithelia
- (2010) John J. Castorino et al. TRAFFIC
- miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1
- (2009) Kay Ka Wai Li et al. HUMAN PATHOLOGY
- Studies on the DIDS-binding Site of Monocarboxylate Transporter 1 Suggest a Homology Model of the Open Conformation and a Plausible Translocation Cycle
- (2009) Marieangela C. Wilson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neuronal 3',3,5-Triiodothyronine (T3) Uptake and Behavioral Phenotype of Mice Deficient in Mct8, the Neuronal T3 Transporter Mutated in Allan-Herndon-Dudley Syndrome
- (2009) E. K. Wirth et al. JOURNAL OF NEUROSCIENCE
- Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse γ-Hydroxybutyric Acid
- (2008) Marilyn E. Morris et al. AAPS Journal
- Sodium-coupled Monocarboxylate Transporters in Normal Tissues and in Cancer
- (2008) Vadivel Ganapathy et al. AAPS Journal
- Mutation of Solute Carrier SLC16A12 Associates with a Syndrome Combining Juvenile Cataract with Microcornea and Renal Glucosuria
- (2008) Barbara Kloeckener-Gruissem et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice
- (2008) Lauren L. Daniele et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
- (2008) Seema Saksena et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Monocarboxylate transporter (MCT)-1 is up-regulated by PPARα
- (2008) Bettina König et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Tissue-specific mRNA Expression Profiles of Human Solute Carrier Transporter Superfamilies
- (2008) Masuhiro Nishimura et al. Drug Metabolism and Pharmacokinetics
- Expression of the Thyroid Hormone Transporters Monocarboxylate Transporter-8 (SLC16A2) and Organic Ion Transporter-14 (SLCO1C1) at the Blood-Brain Barrier
- (2008) Lori M. Roberts et al. ENDOCRINOLOGY
- Nonenzymatic Proton Handling by Carbonic Anhydrase II during H+-Lactate Cotransport via Monocarboxylate Transporter 1
- (2008) Holger M. Becker et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RNA interference screen for human genes associated with West Nile virus infection
- (2008) Manoj N. Krishnan et al. NATURE
- Regulation of monocarboxylate transporter 1 (MCT1) promoter by butyrate in human intestinal epithelial cells: Involvement of NF-κB pathway
- (2007) Alip Borthakur et al. JOURNAL OF CELLULAR BIOCHEMISTRY
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