Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

Biomechanics of vascular mechanosensation and remodeling

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The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence

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Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex

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Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

(2015) Irene Maria Aspalter et al.   Nature Communications

Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point

(2015) Nicolas Baeyens et al.   eLife

Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges

(2015) Simon Tual-Chalot et al.   Frontiers in Genetics

Emerging roles of BMP9 and BMP10 in hereditary hemorrhagic telangiectasia

(2015) Emmanuelle Tillet et al.   Frontiers in Genetics

Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostics in a new era

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Common and Distinctive Pathogenetic Features of Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia 1 and Hereditary Hemorrhagic Telangiectasia 2 Animal Models—Brief Report

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Computer simulations reveal complex distribution of haemodynamic forces in a mouse retina model of angiogenesis

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Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression

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Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling

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Endothelial signaling and the molecular basis of arteriovenous malformation

(2013) Deepak Atri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence

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BMP9 and BMP10 are critical for postnatal retinal vascular remodeling

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ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow

(2012) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction between alk1 and blood flow in the development of arteriovenous malformations

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Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

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Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment

(2010) Claire L. Shovlin   BLOOD REVIEWS

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia

(2009) Sung Ok Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

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