Endoglin interacts with VEGFR2 to promote angiogenesis

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling

(2017) Yi Jin et al.   NATURE CELL BIOLOGY

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues

(2017) Wade W. Sugden et al.   NATURE CELL BIOLOGY

Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer

(2016) M Paauwe et al.   ONCOGENE

A phase I study of TRC105 anti-endoglin (CD105) antibody in metastatic castration-resistant prostate cancer

(2015) Fatima H. Karzai et al.   BJU INTERNATIONAL

Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment

(2015) H Tian et al.   ONCOGENE

A phase II study of TRC105 in patients with hepatocellular carcinoma who have progressed on sorafenib

(2015) AG Duffy et al.   United European Gastroenterology Journal

An Open-Label Phase Ib Dose-Escalation Study of TRC105 (Anti-Endoglin Antibody) with Bevacizumab in Patients with Advanced Cancer

(2014) M. S. Gordon et al.   CLINICAL CANCER RESEARCH

ENDOGLIN Is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-Induced Angiogenesis

(2014) Zhen Liu et al.   PLoS One

Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment

(2013) Daniela S. Ardelean et al.   ANGIOGENESIS

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

(2013) Charlotte Anderberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bevacizumab plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) as the second-line therapy for patients with metastatic colorectal cancer, a multicenter study

(2013) Ting Deng et al.   MEDICAL ONCOLOGY

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling

(2012) N. Ricard et al.   BLOOD

A Phase I First-in-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer

(2012) L. S. Rosen et al.   CLINICAL CANCER RESEARCH

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells

(2012) Hongyu Tian et al.   EMBO JOURNAL

Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis

(2012) Nam Y. Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output

(2011) K. Ballmer-Hofer et al.   BLOOD

Hereditary hemorrhagic telangiectasia: An overview of diagnosis, management, and pathogenesis

(2011) Jamie McDonald et al.   GENETICS IN MEDICINE

Inhibitory Effects of SU5416, a Selective Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, on Experimental Corneal Neovascularization

(2011) Uğurcan Keskin et al.   OPHTHALMIC RESEARCH

Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin

(2010) Marwa Mahmoud et al.   CIRCULATION RESEARCH

VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis

(2010) Anthony A. Lanahan et al.   DEVELOPMENTAL CELL

Transforming growth factor-beta signaling and tumor angiogenesis

(2010) Evangelia Pardali   Frontiers in Bioscience-Landmark

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

(2010) Suphansa Sawamiphak et al.   NATURE

ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration

(2009) Bridgette N. Ray et al.   CARCINOGENESIS

The effect of bevacizumab (Avastin) treatment on epistaxis in hereditary hemorrhagic telangiectasia

(2009) Jana Simonds et al.   LARYNGOSCOPE

Ligand-Stimulated VEGFR2 Signaling is Regulated by Co-Ordinated Trafficking and Proteolysis

(2009) Alexander F. Bruns et al.   TRAFFIC

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH

Angiogenesis, hypoxia and VEGF expression during tumour growth in a human xenograft tumour model

(2008) E.M. Hendriksen et al.   MICROVASCULAR RESEARCH

Spheroid-based engineering of a human vasculature in mice

(2008) Abdullah Alajati et al.   NATURE METHODS