miR-124-5p/NOX2 Axis Modulates the ROS Production and the Inflammatory Microenvironment to Protect Against the Cerebral I/R Injury

Nucleic Acid Therapies for Ischemic Stroke

(2019) Nils Henninger et al.   Neurotherapeutics

LncRNA TINCR/miR-31-5p/C/EBP-α feedback loop modulates the adipogenic differentiation process in human adipose tissue-derived mesenchymal stem cells

(2018) Yutong Liu et al.   Stem Cell Research

Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke

(2017) Yuan-Yuan Qin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Postischemic Inflammation in Acute Stroke

(2017) Simone Vidale et al.   Journal of Clinical Neurology

MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

(2016) Somayyeh Hamzei Taj et al.   BIOMATERIALS

NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease

(2016) J Haslund-Vinding et al.   BRITISH JOURNAL OF PHARMACOLOGY

An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress

(2016) Pengfei Li et al.   MOLECULAR NEUROBIOLOGY

NADPH oxidase 2 does not contribute to early reperfusion-associated reactive oxygen species generation following transient focal cerebral ischemia

(2016) Wen-lan Liu et al.   Neural Regeneration Research

Absence of galectin-3 attenuates neuroinflammation improving functional recovery after spinal cord injury

(2016) AnaMaria Blanco Martinez et al.   Neural Regeneration Research

Effects of Hypoxia and Ischemia on MicroRNAs in the Brain

(2015) Yilin Yang et al.   CURRENT MEDICINAL CHEMISTRY

Uric Acid and Cu/Zn Superoxide Dismutase: Potential Strategies and Biomarkers in Functional Recovery of Post-Acute Ischemic Stroke Patients after Intensive Neurorehabilitation

(2015) Irene Ciancarelli et al.   CURRENT NEUROVASCULAR RESEARCH

Capsaicin attenuates LPS-induced inflammatory cytokine production by upregulation of LXRα

(2015) Jing Tang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MicroRNAs: a novel promising therapeutic target for cerebral ischemia/reperfusion injury?

(2015) Ting-hua Wang et al.   Neural Regeneration Research

Convergent microRNA actions coordinate neocortical development

(2014) Olga Barca-Mayo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dicer Knockdown Inhibits Endothelial Cell Tumor Growth via MicroRNA 21a-3p Targeting of Nox-4

(2014) Gayle M. Gordillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alterations in the time course of expression of the Nox family in the brain in a rat experimental cerebral ischemia and reperfusion model: effects of melatonin

(2014) Haiying Li et al.   JOURNAL OF PINEAL RESEARCH

MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart

(2013) Zoltán V. Varga et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNA-124 (miR-124) Regulates Ku70 Expression and is Correlated with Neuronal Death Induced by Ischemia/Reperfusion

(2013) Fei Zhu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Diversifying microRNA sequence and function

(2013) Stefan L. Ameres et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Which NADPH Oxidase Isoform Is Relevant for Ischemic Stroke? The Case for Nox 2

(2012) Timo Kahles et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

(2012) Marie T. Fischer et al.   BRAIN

Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice

(2012) Ahdeah Pajoohesh-Ganji et al.   BRAIN RESEARCH

Protective Effect of Delayed Remote Limb Ischemic Postconditioning: Role of Mitochondrial KATP Channels in a Rat Model of Focal Cerebral Ischemic Reperfusion Injury

(2012) Jing Sun et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injury

(2012) Pamela W. M. Kleikers et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

GBD 2010: design, definitions, and metrics

(2012) Christopher JL Murray et al.   LANCET

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

(2012) Long-Jun Wu et al.   NATURE NEUROSCIENCE

Reperfusion brain injury: Focus on cellular bioenergetics

(2012) S. Pundik et al.   NEUROLOGY

Regulation of NADPH Oxidase Gene Expression with PKA and Cytokine IL-4 in Neurons and Microglia

(2012) Valentina L. Savchenko   NEUROTOXICITY RESEARCH

An Antagomir to MicroRNA Let7f Promotes Neuroprotection in an Ischemic Stroke Model

(2012) Amutha Selvamani et al.   PLoS One

Delayed inflammatory mRNA and protein expression after spinal cord injury

(2011) Kimberly R Byrnes et al.   Journal of Neuroinflammation

p-hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia

(2011) Kyung-Yoon Kam et al.   MOLECULES AND CELLS

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

SnapShot: Reactive Oxygen Intermediates (ROI)

(2010) Carl Nathan et al.   CELL

Oxidative stress and endothelial dysfunction in cerebrovascular disease

(2010) Sophocles Chrissobolis   Frontiers in Bioscience-Landmark

Mechanisms Contributing to Cerebral Infarct Size after Stroke: Gender, Reperfusion, T Lymphocytes, and Nox2-Derived Superoxide

(2010) Vanessa H Brait et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury

(2010) Kenji Dohi et al.   Journal of Neuroinflammation

NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain

(2010) D. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox regulation of Nox proteins

(2010) Srikanth Pendyala et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2009) Rao Muralikrishna Adibhatla et al.   ANTIOXIDANTS & REDOX SIGNALING

To prevent, protect and save the ischemic heart: antioxidants revisited

(2009) Ioanna Andreadou et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inflammatory mechanisms in ischemic stroke: therapeutic approaches

(2009) Shaheen E Lakhan et al.   Journal of Translational Medicine

Global variation in stroke burden and mortality: estimates from monitoring, surveillance, and modelling

(2009) S Claiborne Johnston et al.   LANCET NEUROLOGY

IL-6 Mediated Degeneration of Forebrain GABAergic Interneurons and Cognitive Impairment in Aged Mice through Activation of Neuronal NADPH Oxidase

(2009) Laura L. Dugan et al.   PLoS One

Early increase of Nox4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats

(2008) Sarah K. McCann et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke

(2007) Peter J. Kelly et al.   STROKE