DEAD-box RNA Helicase DDX3: Functional Properties and Development of DDX3 Inhibitors as Antiviral and Anticancer Drugs

HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit

(2019) Gabrielle Vieyres et al.   Cells

DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection

(2019) Annalaura Brai et al.   JOURNAL OF MEDICINAL CHEMISTRY

From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis

(2019) Valentina Riva et al.   Future Medicinal Chemistry

Co‐degradation of interferon signaling factor DDX3 by PB1‐F2 as a basis for high virulence of 1918 pandemic influenza

(2019) Eun‐Sook Park et al.   EMBO JOURNAL

DDX 3X and specific initiation factors modulate FMR 1 repeat‐associated non‐AUG‐initiated translation

(2019) Alexander E Linsalata et al.   EMBO REPORTS

The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X

(2019) He Song et al.   Nature Communications

Spatiotemporal Coupling of the Hepatitis C Virus Replication Cycle by Creating a Lipid Droplet- Proximal Membranous Replication Compartment

(2019) Ji-Young Lee et al.   Cell Reports

Chicken DDX3X Activates IFN-β via the chSTING-chIRF7-IFN-β Signaling Axis

(2019) Qiaona Niu et al.   Frontiers in Immunology

Hepatitis C virus infection is inhibited by a non-canonical antiviral signaling pathway targeted by NS3-NS4A

(2019) Christine Vazquez et al.   JOURNAL OF VIROLOGY

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

(2019) Parimal Samir et al.   NATURE

Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation

(2019) Marina Aksenova et al.   Journal of Neuroimmune Pharmacology

DDX3 activates CBC-eIF3-mediated translation of uORF-containing oncogenic mRNAs to promote metastasis in HNSCC

(2018) Hung-Hsi Chen et al.   CANCER RESEARCH

A double-edged function of DDX3, as an oncogene or tumor suppressor, in cancer progression (Review)

(2018) Yu He et al.   ONCOLOGY REPORTS

Global Effects of DDX3 Inhibition on Cell Cycle Regulation Identified by a Combined Phosphoproteomics and Single Cell Tracking Approach

(2018) Marise R. Heerma van Voss et al.   Translational Oncology

Dengue Virus Capsid Interacts with DDX3X–A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection

(2018) Rinki Kumar et al.   Frontiers in Cellular and Infection Microbiology

Stimulation of the Internal Ribosome Entry Site (IRES)-Dependent Translation of Enterovirus 71 by DDX3X RNA Helicase and Viral 2A and 3C Proteases

(2018) Yu-Siang Su et al.   Frontiers in Microbiology

Redox Biology of Respiratory Viral Infections

(2018) Olga Khomich et al.   Viruses-Basel

Acetylation of intrinsically disordered regions regulates phase separation

(2018) Makoto Saito et al.   Nature Chemical Biology

Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33

(2018) Saritha Tantravedi et al.   Translational Oncology

A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε

(2017) Christine Dolde et al.   JOURNAL OF CELL SCIENCE

Biochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1p

(2017) Deepak Sharma et al.   JOURNAL OF MOLECULAR BIOLOGY

The ATP-Dependent RNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Gene Expression

(2017) Bita Khadivjam et al.   JOURNAL OF VIROLOGY

Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment

(2017) M R Heerma van Voss et al.   ONCOGENE

Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer

(2017) Marise Heerma van Voss et al.   OncoTargets and Therapy

RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP

(2017) Tsung-Yuan Tsai et al.   Scientific Reports

DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression

(2017) Pauline Adjibade et al.   Scientific Reports

DEAD-box RNA helicase DDX3 connects CRM1-dependent nuclear export and translation of the HIV-1 unspliced mRNA through its N-terminal domain

(2016) Alvaro Fröhlich et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3

(2016) Min Xie et al.   CANCER RESEARCH

The prognostic effect of DDX3 upregulation in distant breast cancer metastases

(2016) Marise R. Heerma van Voss et al.   CLINICAL & EXPERIMENTAL METASTASIS

DDX3 Interacts with Influenza A Virus NS1 and NP Proteins and Exerts Antiviral Function through Regulation of Stress Granule Formation

(2016) Sathya N. Thulasi Raman et al.   JOURNAL OF VIROLOGY

Oxidative Stress during HIV Infection: Mechanisms and Consequences

(2016) Alexander V. Ivanov et al.   Oxidative Medicine and Cellular Longevity

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

(2016) Annalaura Brai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

(2016) Alexander V. Ivanov et al.   Oncotarget

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

(2016) Sekyung Oh et al.   Oncotarget

Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

(2016) Yasmine A. Valentin-Vega et al.   Scientific Reports

DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis

(2016) Tsung-Ying He et al.   Scientific Reports

The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription

(2016) Nian Xiang et al.   PLoS One

Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs

(2016) Cédric Diot et al.   Scientific Reports

DEAD-box RNA helicase DDX3X inhibits DENV replication via regulating type one interferon pathway

(2015) Guanghao Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

(2015) G. M. Bol et al.   EMBO Molecular Medicine

Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors

(2015) Roberta Fazi et al.   Journal of Chemical Information and Modeling

Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis

(2015) Leslie B. Epling et al.   JOURNAL OF MOLECULAR BIOLOGY

Y-Box Binding Protein 1 Stabilizes Hepatitis C Virus NS5A via Phosphorylation-Mediated Interaction with NS5A To Regulate Viral Propagation

(2015) Wei-Ting Wang et al.   JOURNAL OF VIROLOGY

Control of Hepatitis C Virus Replication in Mouse Liver-Derived Cells by MAVS-Dependent Production of Type I and Type III Interferons

(2015) Anggakusuma et al.   JOURNAL OF VIROLOGY

Dynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus Infection

(2015) Véronique Pène et al.   JOURNAL OF VIROLOGY

DDX3, a potential target for cancer treatment

(2015) Guus Martinus Bol et al.   Molecular Cancer

RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma

(2015) B A Wilky et al.   ONCOGENE

NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3

(2015) Min Xie et al.   Oncotarget

The Cellular Proteins Grb2 and DDX3 Are Increased upon Human Cytomegalovirus Infection and Act in a Proviral Fashion

(2015) Yolaine Cavignac et al.   PLoS One

Dual inhibition of HCV and HIV by ring-expanded nucleosides containing the 5:7-fused imidazo[4,5- e ][1,3]diazepine ring system. In vitro results and implications

(2014) Ning Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein–protein interactions and human cellular cofactors as new targets for HIV therapy

(2014) Cristina Tintori et al.   CURRENT OPINION IN PHARMACOLOGY

DDX3 DEAD-Box RNA Helicase Is a Host Factor That Restricts Hepatitis B Virus Replication at the Transcriptional Level

(2014) C. Ko et al.   JOURNAL OF VIROLOGY

Involvement of Hepatitis C Virus NS5A Hyperphosphorylation Mediated by Casein Kinase I-  in Infectious Virus Production

(2014) T. Masaki et al.   JOURNAL OF VIROLOGY

DDX3 modulates cell adhesion and motility and cancer cell metastasis via Rac1-mediated signaling pathway

(2014) H-H Chen et al.   ONCOGENE

Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicases

(2014) Megha Haridas Upadya   WORLD JOURNAL OF GASTROENTEROLOGY

Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection

(2014) Yasuo Ariumi   Frontiers in Genetics

DDX3 RNA helicase is required for HIV-1 Tat function

(2013) Mariko Yasuda-Inoue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DEAD-Box Helicases Form Nucleotide-Dependent, Long-Lived Complexes with RNA

(2013) Fei Liu et al.   BIOCHEMISTRY

DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication

(2013) Anthony Fullam et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

DEAD-box helicases as integrators of RNA, nucleotide and protein binding

(2013) Andrea A. Putnam et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Human DEAD Box Helicase 3 Couples I B Kinase   to Interferon Regulatory Factor 3 Activation

(2013) L. Gu et al.   MOLECULAR AND CELLULAR BIOLOGY

Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly

(2013) Qisheng Li et al.   NATURE MEDICINE

Analysis of Virion-Incorporated Host Proteins Required for Herpes Simplex Virus Type 1 Infection through a RNA Interference Screen

(2013) Camille Stegen et al.   PLoS One

Expression of the RNA Helicase DDX3 and the Hypoxia Response in Breast Cancer

(2013) Guus M. Bol et al.   PLoS One

Human DDX3 Interacts with the HIV-1 Tat Protein to Facilitate Viral mRNA Translation

(2013) Ming-Chih Lai et al.   PLoS One

RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt- -Catenin Signaling

(2013) C.-M. Cruciat et al.   SCIENCE

Cellular DDX3 regulates Japanese encephalitis virus replication by interacting with viral un-translated regions

(2013) Chen Li et al.   VIROLOGY

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors

(2012) Marco Radi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulation of the type I interferon pathways by culture-adaptive hepatitis C virus core mutants

(2012) Ju-Il Kang et al.   FEBS LETTERS

Identification of RNA-Protein Interaction Networks Involved in the Norovirus Life Cycle

(2012) S. Vashist et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus (HCV) Induces Formation of Stress Granules Whose Proteins Regulate HCV RNA Replication and Virus Assembly and Egress

(2012) U. Garaigorta et al.   JOURNAL OF VIROLOGY

The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes

(2012) Rene Geissler et al.   NUCLEIC ACIDS RESEARCH

From promoting to inhibiting: diverse roles of helicases in HIV-1 Replication

(2012) Rene-Pierre Lorgeoux et al.   Retrovirology

P-body components LSM1, GW182, DDX3, DDX6 and XRN1 are recruited to WNV replication sites and positively regulate viral replication

(2012) Harendra S. Chahar et al.   VIROLOGY

Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response

(2011) Jing-Wen Shih et al.   BIOCHEMICAL JOURNAL

Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?: Figure 1

(2011) Martina Schröder   BIOCHEMICAL SOCIETY TRANSACTIONS

Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation

(2011) Giovanni Maga et al.   ChemMedChem

Translational Regulation of HIV-1 Replication by HIV-1 Rev Cellular Cofactors Sam68, eIF5A, hRIP, and DDX3

(2011) Jinfeng Liu et al.   Journal of Neuroimmune Pharmacology

Host Cell Interactome of HIV-1 Rev Includes RNA Helicases Involved in Multiple Facets of Virus Production

(2011) Souad Naji et al.   MOLECULAR & CELLULAR PROTEOMICS

The DEAD-Box Protein Ded1 Modulates Translation by the Formation and Resolution of an eIF4F-mRNA Complex

(2011) Angela Hilliker et al.   MOLECULAR CELL

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Motif Unique to the Human Dead-Box Protein DDX3 Is Important for Nucleic Acid Binding, ATP Hydrolysis, RNA/DNA Unwinding and HIV-1 Replication

(2011) Anna Garbelli et al.   PLoS One

RNA helicases

(2011) Arnaz Ranji et al.   RNA Biology

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKK  and DDX3

(2010) S. Yu et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis C Virus Core-Derived Peptides Inhibit Genotype 1b Viral Genome Replication via Interaction with DDX3X

(2010) Chaomin Sun et al.   PLoS One

Comparative Structural Analysis of Human DEAD-Box RNA Helicases

(2010) Patrick Schütz et al.   PLoS One

Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN–Beta Induction

(2010) Hiroyuki Oshiumi et al.   PLoS One

Hepatitis B Virus Polymerase Blocks Pattern Recognition Receptor Signaling via Interaction with DDX3: Implications for Immune Evasion

(2010) Haifeng Wang et al.   PLoS Pathogens

The mechanism of ATP-dependent RNA unwinding by DEAD box proteins

(2009) Manuel Hilbert et al.   BIOLOGICAL CHEMISTRY

Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein

(2009) A. G. N. Angus et al.   JOURNAL OF GENERAL VIROLOGY

DDX3 DEAD-Box RNA Helicase Inhibits Hepatitis B Virus Reverse Transcription by Incorporation into Nucleocapsids

(2009) H. Wang et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1

(2009) V. R. DeFilippis et al.   JOURNAL OF VIROLOGY

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

(2008) Renate König et al.   CELL

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

(2008) Didier Soulat et al.   EMBO JOURNAL

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system

(2008) Alexander V. Ivanov et al.   FEBS LETTERS

Pharmacophore Modeling and Molecular Docking Led to the Discovery of Inhibitors of Human Immunodeficiency Virus-1 Replication Targeting the Human Cellular Aspartic Acid−Glutamic Acid−Alanine−Aspartic Acid Box Polypeptide 3

(2008) Giovanni Maga et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ring Expanded Nucleoside Analogues Inhibit RNA Helicase and Intracellular Human Immunodeficiency Virus Type 1 Replication

(2008) Venkat S. R. K. Yedavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Poxvirus K7 Protein Adopts a Bcl-2 Fold: Biochemical Mapping of Its Interactions with Human DEAD Box RNA Helicase DDX3

(2008) Arnout P. Kalverda et al.   JOURNAL OF MOLECULAR BIOLOGY

Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles

(2008) T. Masaki et al.   JOURNAL OF VIROLOGY

Comprehensive Characterization of Extracellular Herpes Simplex Virus Type 1 Virions

(2008) S. Loret et al.   JOURNAL OF VIROLOGY

The DEAD-Box RNA Helicase DDX3 Associates with Export Messenger Ribonucleoproteins as well asTip-associated Protein and Participates in Translational Control

(2008) Ming-Chih Lai et al.   MOLECULAR BIOLOGY OF THE CELL

Knockdown of Cellular RNA Helicase DDX3 by Short Hairpin RNAs Suppresses HIV-1 Viral Replication Without Inducing Apoptosis

(2008) Musarat Ishaq et al.   MOLECULAR BIOTECHNOLOGY

Rates of evolutionary change in viruses: patterns and determinants

(2008) Siobain Duffy et al.   NATURE REVIEWS GENETICS

Oncogenic role of DDX3 in breast cancer biogenesis

(2008) M Botlagunta et al.   ONCOGENE

DEAD-box proteins can completely separate an RNA duplex using a single ATP

(2008) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding

(2008) F. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the interaction of influenza virus polymerase complex with human cell factors

(2008) Núria Jorba et al.   PROTEOMICS