Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation

DDX3 in HIV-1 infection and sensing: A paradox

(2018) Melissa Stunnenberg et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Complement: The Emerging Architect of the Developing Brain

(2018) Liam G. Coulthard et al.   TRENDS IN NEUROSCIENCES

The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs

(2018) Ulf-Peter Guenther et al.   NATURE

How AI technology can tame the scientific literature

(2018) Andy Extance   NATURE

Phenotypic expansion in DDX3X - a common cause of intellectual disability in females

(2018) Xia Wang et al.   Annals of Clinical and Translational Neurology

LION LBD: a Literature-Based Discovery System for Cancer Biology

(2018) Sampo Pyysalo et al.   BIOINFORMATICS

Focus on Translation Initiation of the HIV-1 mRNAs

(2018) Sylvain de Breyne et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium

(2018) Lena Al-Harti et al.   JOURNAL OF NEUROVIROLOGY

DDX3 Participates in Translational Control of Inflammation Induced by Infections and Injuries

(2018) Yu-Chang Ku et al.   MOLECULAR AND CELLULAR BIOLOGY

Genenames.org: the HGNC and VGNC resources in 2019

(2018) Bryony Braschi et al.   NUCLEIC ACIDS RESEARCH

Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33

(2018) Saritha Tantravedi et al.   Translational Oncology

Dysregulation of Neuronal Cholesterol Homeostasis upon Exposure to HIV-1 Tat and Cocaine Revealed by RNA-Sequencing

(2018) Taha Mohseni Ahooyi et al.   Scientific Reports

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity

(2018) Daniel Szappanos et al.   PLoS Pathogens

Current status of HIV/AIDS in the ART era

(2017) Kazuhisa Yoshimura   JOURNAL OF INFECTION AND CHEMOTHERAPY

HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation

(2017) Ernest T. Chivero et al.   JOURNAL OF NEUROSCIENCE

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence

(2017) Ramesh Chandra et al.   NEURON

Role of DDX3 in the pathogenesis of inflammatory bowel disease

(2017) Saritha Tantravedi et al.   Oncotarget

Characterizing microglia activation: a spatial statistics approach to maximize information extraction

(2017) Benjamin M. Davis et al.   Scientific Reports

Multiple Faceted Roles of Cocaine in Potentiation of HAND

(2016) Yu Cai et al.   CURRENT HIV RESEARCH

Fate of microglia during HIV-1 infection: From activation to senescence?

(2016) Natalie C. Chen et al.   GLIA

HIV-1 Tat and Cocaine Impair Survival of Cultured Primary Neuronal Cells via a Mitochondrial Pathway

(2016) Francesca Isabella De Simone et al.   Journal of Neuroimmune Pharmacology

DDX3 Modulates Neurite Development via Translationally Activating an RNA Regulon Involved in Rac1 Activation

(2016) H.-H. Chen et al.   JOURNAL OF NEUROSCIENCE

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

(2016) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Cocaine and mitochondria-related signaling in the brain: A mechanistic view and future directions

(2016) Marcos Roberto de Oliveira et al.   NEUROCHEMISTRY INTERNATIONAL

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

(2016) Annalaura Brai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

(2016) Violeta Chitu et al.   TRENDS IN NEUROSCIENCES

Editorial: HIV and Illicit Drugs of Abuse

(2016) Venkata S. R. Atluri   Frontiers in Microbiology

Creatine Protects Against Mitochondrial Dysfunction Associated with HIV-1 Tat-Induced Neuronal Injury

(2015) Patrick Stevens et al.   CURRENT HIV RESEARCH

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

(2015) G. M. Bol et al.   EMBO Molecular Medicine

Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity

(2015) Danielle N. Doll et al.   JOURNAL OF NEUROCHEMISTRY

Mutations at Tyrosine 88, Lysine 92 and Tyrosine 470 of Human Dopamine Transporter Result in an Attenuation of HIV-1 Tat-Induced Inhibition of Dopamine Transport

(2015) Narasimha M. Midde et al.   Journal of Neuroimmune Pharmacology

BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology

(2015) Michael K. Gilson et al.   NUCLEIC ACIDS RESEARCH

Analog sensitive chemical inhibition of the DEAD-box protein DDX3

(2015) Stephen N. Floor et al.   PROTEIN SCIENCE

Impact of cocaine abuse on HIV pathogenesis

(2015) Sabyasachi Dash et al.   Frontiers in Microbiology

Interactive effects of cocaine on HIV infection: implication in HIV-associated neurocognitive disorder and neuroAIDS

(2015) Santosh Dahal et al.   Frontiers in Microbiology

Mesenchymal stem cells induce the ramification of microglia via the small RhoGTPases Cdc42 and Rac1

(2014) Veronika E. Neubrand et al.   GLIA

Contribution of sodium channels to lamellipodial protrusion and Rac1 and ERK1/2 activation in ATP-stimulated microglia

(2014) Anna-Karin Persson et al.   GLIA

Interactive HIV-1 Tat and Morphine-Induced Synaptodendritic Injury Is Triggered through Focal Disruptions in Na+ Influx, Mitochondrial Instability, and Ca2+ Overload

(2014) S. Fitting et al.   JOURNAL OF NEUROSCIENCE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection

(2014) Yasuo Ariumi   Frontiers in Genetics

DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication

(2013) Anthony Fullam et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function

(2013) Frederick Walker et al.   CURRENT DRUG TARGETS

Synaptic dysfunction in human immunodeficiency virus type-1-positive subjects: inflammation or impaired neuronal plasticity?

(2013) V. Avdoshina et al.   JOURNAL OF INTERNAL MEDICINE

IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase

(2013) Ling Ye et al.   JOURNAL OF NEUROCHEMISTRY

Mutation of Tyrosine 470 of Human Dopamine Transporter is Critical for HIV-1 Tat-Induced Inhibition of Dopamine Transport and Transporter Conformational Transitions

(2013) Narasimha M. Midde et al.   Journal of Neuroimmune Pharmacology

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Cocaine and HIV-1 Interplay in CNS: Cellular and Molecular Mechanisms

(2012) Shilpa Buch et al.   CURRENT HIV RESEARCH

Neuronal toxicity in HIV CNS disease

(2012) Jane Kovalevich et al.   Future Virology

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Microglial Activation – Tuning and Pruning Adult Neurogenesis

(2012) Christine T. Ekdahl   Frontiers in Pharmacology

Endogenous amyloidogenesis in long-term rat hippocampal cell cultures

(2011) Sarah J Bertrand et al.   BMC NEUROSCIENCE

Current understanding of HIV-associated neurocognitive disorders pathogenesis

(2011) Patrick Gannon et al.   CURRENT OPINION IN NEUROLOGY

Brain-Cocaine Concentrations Determine the Dose Self-Administered by Rats on a Novel Behaviorally Dependent Dosing Schedule

(2011) Benjamin A Zimmer et al.   NEUROPSYCHOPHARMACOLOGY

Epidemiologic Links Between Drug Use and HIV Epidemics: An International Perspective

(2010) Chris Beyrer et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Acquired immunodeficiency syndrome and the blood-brain barrier

(2009) Nathan S Ivey et al.   JOURNAL OF NEUROVIROLOGY

Neuronal survival and resistance to HIV-1 Tat toxicity in the primary culture of rat fetal neurons

(2008) Marina V. Aksenova et al.   EXPERIMENTAL NEUROLOGY

Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies

(2008)   LANCET