Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment

RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3

(2016) Min Xie et al.   CANCER RESEARCH

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer

(2016) D S Matassa et al.   CELL DEATH AND DIFFERENTIATION

Stress management by autophagy: Implications for chemoresistance

(2016) Zhao Huang et al.   INTERNATIONAL JOURNAL OF CANCER

RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation

(2016) Robert A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

DDX3 DEAD-box RNA helicase plays a central role in mitochondrial protein quality control in Leishmania

(2016) Prasad Kottayil Padmanabhan et al.   Cell Death & Disease

Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer

(2016) Pasquale Sansone et al.   Nature Communications

Tumors and Mitochondrial Respiration: A Neglected Connection

(2015) Andrea Viale et al.   CANCER RESEARCH

SIRT1/PGC1 -Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

(2015) T. T. Vellinga et al.   CLINICAL CANCER RESEARCH

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

(2015) G. M. Bol et al.   EMBO Molecular Medicine

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma

(2015) B A Wilky et al.   ONCOGENE

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer

(2015) Marise R. Heerma van Voss et al.   Oncotarget

High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant

(2015) Gillian Farnie et al.   Oncotarget

CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair

(2015) Lili Qin et al.   Cell Reports

DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability

(2015) Bo Qin et al.   Cell Reports

The Human Mitochondrial DEAD-Box Protein DDX28 Resides in RNA Granules and Functions in Mitoribosome Assembly

(2015) Ya-Ting Tu et al.   Cell Reports

Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis

(2015) Hana Antonicka et al.   Cell Reports

Tumor Cells Switch to Mitochondrial Oxidative Phosphorylation under Radiation via mTOR-Mediated Hexokinase II Inhibition - A Warburg-Reversing Effect

(2015) Chung-Ling Lu et al.   PLoS One

DDX3 modulates cell adhesion and motility and cancer cell metastasis via Rac1-mediated signaling pathway

(2014) H-H Chen et al.   ONCOGENE

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

The Reactome pathway knowledgebase

(2013) David Croft et al.   NUCLEIC ACIDS RESEARCH

Expression of the RNA Helicase DDX3 and the Hypoxia Response in Breast Cancer

(2013) Guus M. Bol et al.   PLoS One

Systematic Interrogation of 3q26 Identifies TLOC1 and SKIL as Cancer Drivers

(2013) D. Hagerstrand et al.   Cancer Discovery

Locoregional treatments for triple-negative breast cancer

(2012) W. Eiermann et al.   ANNALS OF ONCOLOGY

DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs

(2012) Ricardo Soto-Rifo et al.   EMBO JOURNAL

Radiosensitization by Inhibiting Complex I activity in Human Hepatoma HepG2 cells to X-ray Radiation

(2012) Xin ZHANG et al.   JOURNAL OF RADIATION RESEARCH

The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes

(2012) Rene Geissler et al.   NUCLEIC ACIDS RESEARCH

STRING v9.1: protein-protein interaction networks, with increased coverage and integration

(2012) Andrea Franceschini et al.   NUCLEIC ACIDS RESEARCH

Nuclear Kaiso Expression Is Associated with High Grade and Triple-Negative Invasive Breast Cancer

(2012) Jeroen F. Vermeulen et al.   PLoS One

Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response

(2011) Jing-Wen Shih et al.   BIOCHEMICAL JOURNAL

The role of DDX3 in regulating Snail

(2011) Mianen Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

Novel, Broad Spectrum Anticancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System

(2011) Atul Kondaskar et al.   ACS Medicinal Chemistry Letters

Bypassing of stems versus linear base-by-base inspection of mammalian mRNAs during ribosomal scanning

(2010) Irina S Abaeva et al.   EMBO JOURNAL

DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-β-inducing potential

(2010) Hiroyuki Oshiumi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DDX3 Regulates Cell Growth through Translational Control of Cyclin E1

(2010) M.-C. Lai et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The current understanding of Ded1p/DDX3 homologs from yeast to human

(2010) Woan-Yuh Tarn et al.   RNA Biology

MDA-MB-435 and M14 Cell Lines: Identical but not M14 Melanoma?

(2009) Ann F. Chambers   CANCER RESEARCH

Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein

(2009) A. G. N. Angus et al.   JOURNAL OF GENERAL VIROLOGY

The DEAD-Box RNA Helicase DDX3 Associates with Export Messenger Ribonucleoproteins as well asTip-associated Protein and Participates in Translational Control

(2008) Ming-Chih Lai et al.   MOLECULAR BIOLOGY OF THE CELL

Human DDX3 functions in translation and interacts with the translation initiation factor eIF3

(2008) C.-S. Lee et al.   NUCLEIC ACIDS RESEARCH

Oncogenic role of DDX3 in breast cancer biogenesis

(2008) M Botlagunta et al.   ONCOGENE