Journal
MOLECULES
Volume 22, Issue 9, Pages -Publisher
MDPI AG
DOI: 10.3390/molecules22091413
Keywords
Pteris ensiformis; dihydrochalcone; diterpenoid; inhibitory activity on nitric oxide production; cytotoxic activity
Funding
- Natural Science Foundation of Liaoning Province of China [20170540201]
- State Key Laboratory of Bioactive Substance and Function of Natural Medicines
- Dalian Nationalities University
- Heilongjiang University of Chinese Medicine [201736]
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Two new dihydrochalcone enantiomers (+)-1 and (-)-1, along with eight known compounds 3-10, were obtained from Pteris ensiformis. The planar structures were determined on the basis of extensive 1D and 2DNMR and HRESIMS. The resolution of (+)-1 and (-)-1 was achieved by chiral HPLC analysis. The absolute configurations of (+)- 1 and ()- 1 were established by the bulkiness rule using Rh-2(O2CCF3)(4)-induced circular dichroism (ICD) method. Compounds (+)-1, (-)-1, 8, 9 and 10 exhibited the inhibitory assay of NO production in mouse macrophages stimulated by LPS, with IC50 values of 2.0, 2.5, 8.0, 9.5 and 5.6 mu M, respectively. Otherwise, compound 10 showed moderate cytotoxic activity against HCT-116, HepG-2 and BGC-823 cell lines with IC50 values of 3.0, 10.5 and 6.3 mu M, respectively.
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