Purine and pyrimidine transporters of pathogenic protozoa – conduits for therapeutic agents

C6–O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents

(2020) Fabian Hulpia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Alternative oxidase inhibitors: Mitochondrion-targeting as a strategy for new drugs against pathogenic parasites and fungi

(2019) Godwin U. Ebiloma et al.   MEDICINAL RESEARCH REVIEWS

Structures of human ENT1 in complex with adenosine reuptake inhibitors

(2019) Nicholas J. Wright et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tales of tails in transporters

(2019) Emmanuel Mikros et al.   Open Biology

Discovery of Pyrrolo[2,3-b]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-Trypanosoma cruzi Agents

(2019) Cai Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

(2019) Anastasia Khandazhinskaya et al.   MOLECULES

Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum

(2019) Arijit Bhattacharya et al.   mSystems

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

(2019) Fabian Hulpia et al.   Nature Communications

Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

(2018) Bianca Zingales   ACTA TROPICA

Parasite Sensing of Host Nutrients and Environmental Cues

(2018) Vanessa Zuzarte-Luís et al.   Cell Host & Microbe

Concentration of 2′C-methyladenosine triphosphate byLeishmania guyanensisenables specific inhibition ofLeishmaniaRNA virus 1 via its RNA polymerase

(2018) John I. Robinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trypanosoma brucei bloodstream forms express highly specific and separate transporters for adenine and hypoxanthine; evidence for a new protozoan purine transporter family?

(2018) Gustavo D. Campagnaro et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli

(2018) Maria Botou et al.   MOLECULAR MICROBIOLOGY

Cloning and characterisation of the Equilibrative Nucleoside Transporter family of Trypanosoma cruzi: ultra-high affinity and selectivity to survive in the intracellular niche

(2018) Gustavo D. Campagnaro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The criminal association of Leishmania parasites and viruses

(2018) Matteo Rossi et al.   CURRENT OPINION IN MICROBIOLOGY

Recent developments in nucleobase cation symporter-1 (NCS1) family transport proteins from bacteria, archaea, fungi and plants

(2018) Simon G Patching   JOURNAL OF BIOSCIENCES

Discovery of novel 7-aryl 7-deazapurine 3’-deoxy-ribofuranosyl nucleosides with potent activity against Trypanosoma cruzi

(2018) Fabian Hulpia et al.   JOURNAL OF MEDICINAL CHEMISTRY

NAT/NCS2-hound: a webserver for the detection and evolutionary classification of prokaryotic and eukaryotic nucleobase-cation symporters of the NAT/NCS2 family

(2018) A Chaliotis et al.   GigaScience

Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity

(2018) Fabian Hulpia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Transporters of Trypanosoma brucei -phylogeny, physiology, pharmacology

(2017) Remo S. Schmidt et al.   FEBS Journal

Fluorinated nucleosides as an important class of anticancer and antiviral agents

(2017) Alessandra Cavaliere et al.   Future Medicinal Chemistry

Treatment with 3′-deoxyadenosine and deoxycoformycin in mice infected by Trypanosoma cruzi and its side effect on purinergic enzymes

(2017) Guilherme M. do Carmo et al.   MICROBIAL PATHOGENESIS

Nutrient acquisition strategies of mammalian cells

(2017) Wilhelm Palm et al.   NATURE

Antiviral screening identifies adenosine analogs targeting the endogenous dsRNALeishmaniaRNA virus 1 (LRV1) pathogenicity factor

(2017) F. Matthew Kuhlmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The superfamily keeps growing: Identification in trypanosomatids of RibJ, the first riboflavin transporter family in protists

(2017) Darío E. Balcazar et al.   PLoS Neglected Tropical Diseases

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

(2017) Khalid J.H. Alzahrani et al.   International Journal for Parasitology-Drugs and Drug Resistance

A CRISPR Cas9 high-throughput genome editing toolkit for kinetoplastids

(2017) Tom Beneke et al.   Royal Society Open Science

The SLC28 (CNT) and SLC29 (ENT) nucleoside transporter families: a 30-year collaborative odyssey

(2016) J. D. Young   BIOCHEMICAL SOCIETY TRANSACTIONS

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense

(2016) Fabrice E. Graf et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs

(2016) Jadd Shelton et al.   CHEMICAL REVIEWS

Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism

(2016) Andrew P. Jackson et al.   CURRENT BIOLOGY

Simple and efficient synthesis of 5 ′ -aryl- 5 ′ -deoxyguanosine analogs by azide-alkyne click reaction and their antileishmanial activities

(2016) Pierre Daligaux et al.   MOLECULAR DIVERSITY

Cryptic purine transporters inAspergillus nidulansreveal the role of specific residues in the evolution of specificity in the NCS1 family

(2016) Georgia Sioupouli et al.   MOLECULAR MICROBIOLOGY

HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment

(2016) Lauren N. Bowen et al.   Nature Reviews Neurology

Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity

(2016) Yilmaz Alguel et al.   Nature Communications

Targeting the Plasmodium vivax equilibrative nucleoside transporter 1 (PvENT1) for antimalarial drug development

(2016) Roman Deniskin et al.   International Journal for Parasitology-Drugs and Drug Resistance

Yeast-Based High-Throughput Screen Identifies Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitors That Kill Malaria Parasites

(2015) I. J. Frame et al.   ACS Chemical Biology

Targeting the Parasite's DNA with Methyltriazenyl Purine Analogs Is a Safe, Selective, and Efficacious Antitrypanosomal Strategy

(2015) Boris Rodenko et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis of 5-isoxazol-3-yl-pyrimidine nucleosides as potential antileishmanial agents

(2015) Shenghai Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oligomerization of the UapA Purine Transporter Is Critical for ER-Exit, Plasma Membrane Localization and Turnover

(2015) Olga Martzoukou et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional analysis of drug resistance-associated mutations in theTrypanosoma bruceiadenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein

(2015) Jane C. Munday et al.   MOLECULAR MICROBIOLOGY

Origin, diversification and substrate specificity in the family of NCS1/FUR transporters

(2015) Emilia Krypotou et al.   MOLECULAR MICROBIOLOGY

Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals

(2015) Junji Furukawa et al.   Scientific Reports

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei

(2015) Jane C. Munday et al.   Frontiers in Pharmacology

Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets

(2015) Marçal Pastor-Anglada et al.   Frontiers in Pharmacology

Purine import into malaria parasites as a target for antimalarial drug development

(2014) I. J. Frame et al.   Annals of the New York Academy of Sciences

Biochemical characterization and structure–function relationship of two plant NCS2 proteins, the nucleobase transporters NAT3 and NAT12 from Arabidopsis thaliana

(2014) Sandra Niopek-Witz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Identification of the Intracellular Gate for a Member of the Equilibrative Nucleoside Transporter (ENT) Family

(2014) Raquel Valdés et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modelling, substrate docking and mutational analysis identify residues essential for function and specificity of the major fungal purine transporter AzgA

(2014) Emilia Krypotou et al.   MOLECULAR MICROBIOLOGY

A short RNA stem-loop is necessary and sufficient for repression of gene expression during early logarithmic phase in trypanosomes

(2014) S. M. Fernandez-Moya et al.   NUCLEIC ACIDS RESEARCH

Why do malaria parasites increase host erythrocyte permeability?

(2014) Sanjay A. Desai   TRENDS IN PARASITOLOGY

Global Metabolomic Profiling of Acute Myocarditis Caused by Trypanosoma cruzi Infection

(2014) Núria Gironès et al.   PLoS Neglected Tropical Diseases

Metabolic Reprogramming during Purine Stress in the Protozoan Pathogen Leishmania donovani

(2014) Jessica L. Martin et al.   PLoS Pathogens

Nucleobase and nucleoside transport and integration into plant metabolism

(2014) Christopher Girke et al.   Frontiers in Plant Science

Experimental cerebral malaria is suppressed by disruption of nucleoside transporter 1 but not purine nucleoside phosphorylase

(2013) Mamoru Niikura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Host Metabolism Regulates Intracellular Growth of Trypanosoma cruzi

(2013) Kacey L. Caradonna et al.   Cell Host & Microbe

5′-Trityl-Substituted Thymidine Derivatives as a Novel Class of Antileishmanial Agents:Leishmania infantumEndoG as a Potential Target

(2013) Elena Casanova et al.   ChemMedChem

Synthesis, physicochemical properties of allopurinol derivatives and their biological activity against Trypanosoma cruzi

(2013) M.A. Raviolo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

(2013) J. C. Munday et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Functional Identification of the Hypoxanthine/Guanine Transporters YjcD and YgfQ and the Adenine Transporters PurP and YicO ofEscherichia coliK-12

(2013) Konstantinos Papakostas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–Activity Relationships of Synthetic Cordycepin Analogues as Experimental Therapeutics for African Trypanosomiasis

(2013) Suman K. Vodnala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenine and adenosine salvage in Leishmania donovani

(2013) Jan M. Boitz et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The sodium-dependent ascorbic acid transporter family SLC23

(2013) Marc Bürzle et al.   MOLECULAR ASPECTS OF MEDICINE

The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29

(2013) James D. Young et al.   MOLECULAR ASPECTS OF MEDICINE

Pyrimidine Biosynthesis Is Not an Essential Function for Trypanosoma brucei Bloodstream Forms

(2013) Juma A. M. Ali et al.   PLoS One

A Cell-surface Phylome for African Trypanosomes

(2013) Andrew P. Jackson et al.   PLoS Neglected Tropical Diseases

Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake

(2013) Jane C. Munday et al.   International Journal for Parasitology-Drugs and Drug Resistance

Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity

(2013) Alexandra Lüscher et al.   International Journal for Parasitology-Drugs and Drug Resistance

Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity

(2012) I. J. Frame et al.   BIOCHEMICAL JOURNAL

Nucleoside transporters: biological insights and therapeutic applications

(2012) Jung-Suk Choi et al.   Future Medicinal Chemistry

Validation of novel fluorescence assays for the routine screening of drug susceptibilities of Trichomonas vaginalis

(2012) Manal J. Natto et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Adenine Aminohydrolase fromLeishmania donovani

(2012) Jan M. Boitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine Cross-linking Defines the Extracellular Gate for theLeishmania donovaniNucleoside Transporter 1.1 (LdNT1.1)

(2012) Raquel Valdés et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amino Acid-Polyamine-Organocation Superfamily

(2012) Foon H. Wong et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å

(2012) Zachary Lee Johnson et al.   NATURE

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

(2012) N. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcript Level Responses of Plasmodium falciparum to Antimycin A

(2012) Sarah J. Tarr et al.   PROTIST

Leishmania Metacyclogenesis Is Promoted in the Absence of Purines

(2012) Tiago Donatelli Serafim et al.   PLoS Neglected Tropical Diseases

Trypanocidal Furamidine Analogues: Influence of Pyridine Nitrogens on Trypanocidal Activity, Transport Kinetics, and Resistance Patterns

(2011) Christopher P. Ward et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm

(2011) Muneaki Hashimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Biology of Nucleoside Transporters and their Distributions and Functions in the Brain

(2011) Fiona E. Parkinson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Diamidine Diminazene Aceturate Is a Substrate for the High-Affinity Pentamidine Transporter: Implications for the Development of High Resistance Levels in Trypanosomes

(2011) I. A. Teka et al.   MOLECULAR PHARMACOLOGY

Structure and mechanism of the uracil transporter UraA

(2011) Feiran Lu et al.   NATURE

Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: Biological activities and selective toxicities

(2010) Omar N. Al Safarjalani et al.   BIOCHEMICAL PHARMACOLOGY

Practical and efficient synthesis of pyrano[3,2-c]pyridone, pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents

(2010) Xuesen Fan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The ubiquitous Nucleobase-Ascorbate Transporter (NAT) family: Lessons from model microbial genetic systems

(2010) George Diallinas et al.   Channels

Inhibitors of the Purine Salvage Pathway: A Valuable Approach for Antiprotozoal Chemotherapy?

(2010) M. Berg et al.   CURRENT MEDICINAL CHEMISTRY

Adenine metabolism in Plasmodium falciparum

(2010) Sonali Mehrotra et al.   EXPERIMENTAL PARASITOLOGY

Avirulent Uracil Auxotrophs Based on Disruption of Orotidine-5'-Monophosphate Decarboxylase Elicit Protective Immunity to Toxoplasma gondii

(2010) B. A. Fox et al.   INFECTION AND IMMUNITY

Transmembrane Segment 11 Appears to Line the Purine Permeation Pathway of thePlasmodium falciparumEquilibrative Nucleoside Transporter 1 (PfENT1)

(2010) Paul M. Riegelhaupt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PfNT2, a Permease of the Equilibrative Nucleoside Transporter Family in the Endoplasmic Reticulum ofPlasmodium falciparum

(2010) Megan J. Downie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High AffinityS-Adenosylmethionine Plasma Membrane Transporter ofLeishmaniaIs a Member of the Folate Biopterin Transporter (FBT) Family

(2010) Larbi Dridi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter

(2010) Neils B Quashie et al.   MALARIA JOURNAL

Intermediary Metabolism in Protists: a Sequence-based View of Facultative Anaerobic Metabolism in Evolutionarily Diverse Eukaryotes

(2010) Michael L. Ginger et al.   PROTIST

Nucleoside Transporter Proteins

(2009) Miriam Molina-Arcas et al.   Current Vascular Pharmacology

Identification of subspecies specific genes differentially expressed in procyclic forms of Trypanosoma brucei subspecies

(2009) Gustave Simo et al.   INFECTION GENETICS AND EVOLUTION

Identification and Functional Characterization of the First Nucleobase Transporter in Mammals

(2009) Syunsuke Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anab InitioStructural Model of a Nucleoside Permease Predicts Functionally Important Residues

(2009) Raquel Valdés et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Acid-activated Nucleobase Transporter fromLeishmania major

(2009) Diana Ortiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1

(2009) Paul M. Riegelhaupt et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Protein composition of Trypanosoma brucei mitochondrial membranes

(2009) Nathalie Acestor et al.   PROTEOMICS

A comprehensive model of purine uptake by the malaria parasitePlasmodium falciparum: identification of four purine transport activities in intraerythrocytic parasites

(2008) Neils B. Quashie et al.   BIOCHEMICAL JOURNAL

7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities

(2008) Omar N. Al Safarjalani et al.   BIOCHEMICAL PHARMACOLOGY

Genetic evidence for the essential role of PfNT1 in the transport and utilization of xanthine, guanine, guanosine and adenine by Plasmodium falciparum

(2008) Kamal El Bissati et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Functional analysis and complex gene rearrangements of the folate/biopterin transporter (FBT) gene family in the protozoan parasite Leishmania

(2008) A OUAMEUR et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Two novel nucleobase/pentamidine transporters from Trypanosoma brucei

(2008) D ORTIZ et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Ohno's Model Revisited: Measuring the Frequency of Potentially Adaptive Mutations under Various Mutational Drifts

(2008) Shimon Bershtein et al.   MOLECULAR BIOLOGY AND EVOLUTION

The nucleobase–ascorbate transporter (NAT) family: genomics, evolution, structure–function relationships and physiological role

(2008) Christos Gournas et al.   Molecular BioSystems

Efficacy of the tubercidin antileishmania action associated with an inhibitor of the nucleoside transport

(2008) J. I. Aoki et al.   PARASITOLOGY RESEARCH

Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

(2008) S. Weyand et al.   SCIENCE

Purine nucleobase transport in the intraerythrocytic malaria parasite

(2007) M DOWNIE et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Kinetic and mutational analysis of the Trypanosoma brucei NBT1 nucleobase transporter expressed in Saccharomyces cerevisiae reveals structural similarities between ENT and MFS transporters

(2007) I. Papageorgiou et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Characterisation of the plasma membrane subproteome of bloodstream formTrypanosoma brucei

(2007) Daniel J. Bridges et al.   PROTEOMICS