Fluorinated nucleosides as an important class of anticancer and antiviral agents

Distinct Effects of T-705 (Favipiravir) and Ribavirin on Influenza Virus Replication and Viral RNA Synthesis

(2016) Evelien Vanderlinden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs

(2016) Jadd Shelton et al.   CHEMICAL REVIEWS

Review on TAS-102 development and its use for metastatic colorectal cancer

(2016) Jose Mauricio Mota et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Diastereoselective Synthesis of C2′-Fluorinated Nucleoside Analogues Using an Acyclic Approach

(2016) Starr Dostie et al.   JOURNAL OF ORGANIC CHEMISTRY

A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging

(2016) Andrew J. Hoover et al.   ORGANOMETALLICS

The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2

(2016) Dzjemma Sarkisjan et al.   PLoS One

Dual anti-HIV mechanism of clofarabine

(2016) Michele B. Daly et al.   Retrovirology

Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

(2016) Daouda Sissoko et al.   PLOS MEDICINE

A linear synthesis of gemcitabine

(2015) Kylie Brown et al.   CARBOHYDRATE RESEARCH

Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential

(2015) Erik Clercq   CURRENT MEDICINAL CHEMISTRY

Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2′-deoxy-5-fluorouridine into DNA

(2015) KAZUKI SAKAMOTO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Phase 1b study of the oral gemcitabine ‘Pro-drug’ LY2334737 in combination with capecitabine in patients with advanced solid tumors

(2015) Jeffrey R. Infante et al.   INVESTIGATIONAL NEW DRUGS

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Abstract B46: NUC-3373: A novel pyrimidine nucleotide analogue that overcomes key cancer drug resistance limiting patient survival

(2015) Essam A. Ghazaly et al.   MOLECULAR CANCER THERAPEUTICS

Adenine: an important drug scaffold for the design of antiviral agents

(2015) Changyuan Wang et al.   Acta Pharmaceutica Sinica B

Abstract CT401: NUC-1031: A novel ProTide that overcomes the key cancer resistance mechanisms associated with poor survival

(2015) Essam A. Ghazaly et al.   CANCER RESEARCH

Intracellular Effects of the Hepatitis C Virus Nucleoside Polymerase Inhibitor RO5855 (Mericitabine Parent) and Ribavirin in Combination

(2014) H. Ma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis, anti-HIV and cytostatic evaluation of 3′-deoxy-3′-fluorothymidine (FLT) pro-nucleotides

(2014) Winnie Velanguparackel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Nucleoside Phosphate and Phosphonate Prodrugs

(2014) Ugo Pradere et al.   CHEMICAL REVIEWS

Radiosyntheses using Fluorine-18: The Art and Science of Late Stage Fluorination

(2014) Erin Cole et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Trifluoromethylated Nucleosides: A Building Block Approach to Cytotoxic Adenosine Analogues

(2014) Johannes Drexler et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Radiochemical synthesis of 2′-[18F]-labelled and 3′-[18F]-labelled nucleosides for positron emission tomography imaging

(2014) Jan-Philip Meyer et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development

(2014) Magdalena Slusarczyk et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Promising Therapeutic Option Against Hepatitis C Virus: An Oral Nucleotide NS5B Polymerase Inhibitor Sofosbuvir

(2013) I. Gentile et al.   CURRENT MEDICINAL CHEMISTRY

JUMP-C: A randomized trial of mericitabine plus pegylated interferon alpha-2a/ribavirin for 24 weeks in treatment-naïve HCV genotype 1/4 patients

(2013) Paul J. Pockros et al.   HEPATOLOGY

Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360)

(2013) Godefridus J. Peters et al.   INVESTIGATIONAL NEW DRUGS

Effect of Halogen Substitutions on dUMP to Stability of Thymidylate Synthase/dUMP/mTHF Ternary Complex Using Molecular Dynamics Simulation

(2013) Nopporn Kaiyawet et al.   Journal of Chemical Information and Modeling

Randomized, Multicenter, Phase II Study of CO-101 Versus Gemcitabine in Patients With Metastatic Pancreatic Ductal Adenocarcinoma: Including a Prospective Evaluation of the Role of hENT1 in Gemcitabine or CO-101 Sensitivity

(2013) Elizabeth Poplin et al.   JOURNAL OF CLINICAL ONCOLOGY

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

18F Labeling of Arenes

(2012) Matthew Tredwell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase

(2012) Jean-Michel Pawlotsky et al.   ANTIVIRAL THERAPY

Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity

(2012) Won Jun Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gemcitabine versus Modified Gemcitabine: A Review of Several Promising Chemical Modifications

(2012) Elodie Moysan et al.   MOLECULAR PHARMACEUTICS

An improved strategy for the synthesis of [18F]-labeled arabinofuranosyl nucleosides

(2012) Hanwen Zhang et al.   NUCLEAR MEDICINE AND BIOLOGY

The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2′-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes

(2011) Johan Vande Voorde et al.   BIOCHEMICAL PHARMACOLOGY

Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity

(2011) S. Nagai et al.   CANCER RESEARCH

Transition metal catalysis and nucleophilic fluorination

(2011) Charlotte Hollingworth et al.   CHEMICAL COMMUNICATIONS

Phase I Study of Oral Gemcitabine Prodrug (LY2334737) Alone and in Combination with Erlotinib in Patients with Advanced Solid Tumors

(2011) Stijn L.W. Koolen et al.   CLINICAL CANCER RESEARCH

Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126

(2011) Auke D. Adema et al.   INVESTIGATIONAL NEW DRUGS

Phosphoramidate ProTides of the Anticancer Agent FUDR Successfully Deliver the Preformed Bioactive Monophosphate in Cells and Confer Advantage over the Parent Nucleoside

(2011) Christopher McGuigan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

(2011) A. M. Lam et al.   JOURNAL OF VIROLOGY

Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks

(2011) NORIHIKO SUZUKI et al.   Experimental and Therapeutic Medicine

A facile and rapid automated synthesis of 3′-deoxy-3′-[18F]fluorothymidine

(2010) Ganghua Tang et al.   APPLIED RADIATION AND ISOTOPES

Chemical Synthesis of Heterocyclic−Sugar Nucleoside Analogues

(2010) Giovanni Romeo et al.   CHEMICAL REVIEWS

Recent advances in antiretroviral drugs

(2010) Raktim Kumar Ghosh et al.   EXPERT OPINION ON PHARMACOTHERAPY

Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models

(2010) Andries M. Bergman et al.   INVESTIGATIONAL NEW DRUGS

RG7128 Alone or in Combination with Pegylated Interferon‐α2a and Ribavirin Prevents Hepatitis C Virus (HCV) Replication and Selection of Resistant Variants in HCV‐Infected Patients

(2010) Sophie Le Pogam et al.   JOURNAL OF INFECTIOUS DISEASES

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

(2010) Michael J. Sofia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aminodifluorosulfinium Salts: Selective Fluorination Reagents with Enhanced Thermal Stability and Ease of Handling†,‡

(2010) Alexandre L’Heureux et al.   JOURNAL OF ORGANIC CHEMISTRY

Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial

(2010) M Hallek et al.   LANCET

Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia

(2010) Etienne Moussay et al.   Molecular Cancer

Improved synthesis of 2′-deoxy-2′-[18F]-fluoro-1-β-d-arabinofuranosyl-5-iodouracil ([18F]-FIAU)

(2010) Harry Anderson et al.   NUCLEAR MEDICINE AND BIOLOGY

Mechanisms of anti-cancer action and pharmacology of clofarabine

(2009) Anna Zhenchuk et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis, Crystallization, and Biological Evaluation of an Orally Active Prodrug of Gemcitabine

(2009) David M. Bender et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of11C,18F,15O, and13N Radiolabels for Positron Emission Tomography

(2008) Philip W. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

miR-34a as part of the resistance network in chronic lymphocytic leukemia

(2008) T. Zenz et al.   BLOOD

Modulation of Gemcitabine (2',2'-Difluoro-2'-Deoxycytidine) Pharmacokinetics, Metabolism, and Bioavailability in Mice by 3,4,5,6-Tetrahydrouridine

(2008) J. H. Beumer et al.   CLINICAL CANCER RESEARCH

Fluorinated nucleosides: Synthesis and biological implication

(2008) Peng Liu et al.   JOURNAL OF FLUORINE CHEMISTRY

Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues

(2008) Lisa S. Chen et al.   LEUKEMIA RESEARCH