Clinical Pig Kidney Xenotransplantation: How Close Are We?

Carbohydrate antigen expression and anti-pig antibodies in New World capuchin monkeys: Relevance to studies of xenotransplantation

(2019) Qi Li et al.   XENOTRANSPLANTATION

Justification of specific genetic modifications in pigs for clinical organ xenotransplantation

(2019) David K. C. Cooper et al.   XENOTRANSPLANTATION

LIFE-SUPPORTING KIDNEY XENOTRANSPLANTATION FROM GENETICALLY-ENGINEERED PIGS IN BABOONS

(2019) Takayuki Yamamoto et al.   TRANSPLANTATION

Paediatric xenotransplantation clinical trials and the right to withdraw

(2019) Daniel J Hurst et al.   JOURNAL OF MEDICAL ETHICS

Infectious disease risks in xenotransplantation

(2018) Jay A. Fishman   AMERICAN JOURNAL OF TRANSPLANTATION

Who can tolerate a marginal kidney? Predicting survival after deceased donor kidney transplant by donor-recipient combination

(2018) Sunjae Bae et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Swine Leukocyte Antigen Class II Is a Xenoantigen

(2018) Joseph M. Ladowski et al.   TRANSPLANTATION

Immune Responses of HLA Highly Sensitized and Nonsensitized Patients to Genetically Engineered Pig Cells

(2018) Zhongqiang Zhang et al.   TRANSPLANTATION

Overcoming Coagulation Dysregulation in Pig Solid Organ Transplantation in Nonhuman Primates

(2018) Liaoran Wang et al.   TRANSPLANTATION

Pigs expressing the human inhibitory ligand PD-L1 (CD 274) provide a new source of xenogeneic cells and tissues with low immunogenic properties

(2018) Anna Buermann et al.   XENOTRANSPLANTATION

Is sensitization to pig antigens detrimental to subsequent allotransplantation?

(2018) Qi Li et al.   XENOTRANSPLANTATION

Jewish, Christian and Muslim theological perspectives about xenotransplantation

(2018) Wayne Paris et al.   XENOTRANSPLANTATION

Physiologic Aspects of Pig Kidney Transplantation in Nonhuman Primates

(2018) Hayato Iwase et al.   COMPARATIVE MEDICINE

Perspectives on the Optimal Genetically-Engineered pig in 2018 for Initial Clinical Trials of Kidney or Heart Xenotransplantation

(2018) David K.C. Cooper et al.   TRANSPLANTATION

The national landscape of deceased donor kidney transplantation for the highly sensitized: Transplant rates, waitlist mortality, and posttransplant survival under KAS

(2018) Kyle R. Jackson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival

(2018) Andrew B. Adams et al.   ANNALS OF SURGERY

Chronic dialysis in patients with end-stage renal disease: Relevance to kidney xenotransplantation

(2018) Abhijit Jagdale et al.   XENOTRANSPLANTATION

Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance?

(2018) Hayato Iwase et al.   XENOTRANSPLANTATION

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs

(2017) Gregory R. Martens et al.   TRANSPLANTATION

Selection of Patients for Initial Clinical Trials of Solid Organ Xenotransplantation

(2017) David K.C. Cooper et al.   TRANSPLANTATION

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans

(2017) Bingsi Gao et al.   PLoS One

Survival Benefit with Kidney Transplants from HLA-Incompatible Live Donors

(2016) Babak J. Orandi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The pathobiology of pig-to-primate xenotransplantation: a historical review

(2016) David K.C. Cooper et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein

(2015) Agnes M. Azimzadeh et al.   XENOTRANSPLANTATION

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

(2015) Laura Higginbotham et al.   XENOTRANSPLANTATION

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease

(2014) Luz M. Reyes et al.   JOURNAL OF IMMUNOLOGY

Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature

(2014) David K. C. Cooper et al.   XENOTRANSPLANTATION

Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen

(2014) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status

(2013) Hidetaka Hara et al.   IMMUNOLOGY

Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice

(2012) N. Klymiuk et al.   DIABETES

Human CD55 Expression Blocks Hyperacute Rejection and Restricts Complement Activation in Gal Knockout Cardiac Xenografts

(2012) Christopher G.A. McGregor et al.   TRANSPLANTATION

Pathologic Characteristics of Transplanted Kidney Xenografts

(2011) A. Shimizu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Downregulation of cytolytic activity of human effector cells by transgenic expression of human PD-ligand-1 on porcine target cells

(2010) Annegret Plege et al.   TRANSPLANT INTERNATIONAL

Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs

(2009) Jagdeece Ramsoondar et al.   XENOTRANSPLANTATION

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

(2009) Carol J. Phelps et al.   XENOTRANSPLANTATION

Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs

(2008) Britta Dieckhoff et al.   XENOTRANSPLANTATION