Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection

(2017) Kapil Saxena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Reovirus intermediate subviral particles constitute a strategy to infect intestinal epithelial cells by exploiting TGF-β dependent pro-survival signaling

(2016) Megan L. Stanifer et al.   CELLULAR MICROBIOLOGY

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Correction: Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections

(2016) Jian-Da Lin et al.   PLoS Pathogens

Mini-Gut Organoids: Reconstitution of the Stem Cell Niche

(2015) Shoichi Date et al.   Annual Review of Cell and Developmental Biology

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

(2015) Sina Bartfeld et al.   GASTROENTEROLOGY

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

(2015) Helen M. Lazear et al.   IMMUNITY

IFNλ Stimulates MxA Production in Human Dermal Fibroblasts via a MAPK-Dependent STAT1-Independent Mechanism

(2015) Adewonuola A. Alase et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

(2015) Pedro P Hernández et al.   NATURE IMMUNOLOGY

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

The unique regulation and functions of type III interferons in antiviral immunity

(2015) Charlotte Odendall et al.   Current Opinion in Virology

Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a Compartmentalized Mucosal Defense System that Restricts Enteric Virus Infections

(2015) Tanel Mahlakõiv et al.   PLoS Pathogens

Impairment of Type I but Not Type III IFN Signaling by Hepatitis C Virus Infection Influences Antiviral Responses in Primary Human Hepatocytes

(2015) Jacques Friborg et al.   PLoS One

Human enteroids as an ex-vivo model of host–pathogen interactions in the gastrointestinal tract

(2014) Jennifer Foulke-Abel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Diverse intracellular pathogens activate type III interferon expression from peroxisomes

(2014) Charlotte Odendall et al.   NATURE IMMUNOLOGY

Commensal microbes and interferon-  determine persistence of enteric murine norovirus infection

(2014) M. T. Baldridge et al.   SCIENCE

Interferon-  cures persistent murine norovirus infection in the absence of adaptive immunity

(2014) T. J. Nice et al.   SCIENCE

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus

(2013) Nikolaus Jilg et al.   HEPATOLOGY

Type I and type III interferon-induced immune response: It's a matter of kinetics and magnitude

(2013) David Olagnier et al.   HEPATOLOGY

Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression

(2013) Christopher R. Bolen et al.   HEPATOLOGY

Interferon induction and function at the mucosal surface

(2013) Russell K. Durbin et al.   IMMUNOLOGICAL REVIEWS

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

The Battle between Rotavirus and Its Host for Control of the Interferon Signaling Pathway

(2013) Michelle M. Arnold et al.   PLoS Pathogens

Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia

(2013) Stefania Crotta et al.   PLoS Pathogens

Innate immune signalling at the intestinal epithelium in homeostasis and disease

(2012) Johanna Pott et al.   EMBO REPORTS

Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent

(2012) Philippa Hillyer et al.   IMMUNOLOGY AND CELL BIOLOGY

Combined action of type I and type III interferon restricts initial replication of severe acute respiratory syndrome coronavirus in the lung but fails to inhibit systemic virus spread

(2012) T. Mahlakoiv et al.   JOURNAL OF GENERAL VIROLOGY

Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses

(2012) S. R. Finkbeiner et al.   mBio

Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer

(2012) Deborah C. Rubin et al.   Frontiers in Immunology

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

A Recombinant Vesicular Stomatitis Virus Bearing a Lethal Mutation in the Glycoprotein Gene Uncovers a Second Site Suppressor That Restores Fusion

(2011) M. L. Stanifer et al.   JOURNAL OF VIROLOGY

Generating human intestinal tissue from pluripotent stem cells in vitro

(2011) Kyle W McCracken et al.   Nature Protocols

IFN-  determines the intestinal epithelial antiviral host defense

(2011) J. Pott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Type I interferon: friend or foe?

(2010) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

IL28B inhibits hepatitis C virus replication through the JAK–STAT pathway

(2010) Leiliang Zhang et al.   JOURNAL OF HEPATOLOGY

What Have We Learned from the IL28 Receptor Knockout Mouse?

(2010) Markus Mordstein et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Interferon-Lambda: A New Addition to an Old Family

(2010) Raymond P. Donnelly et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

(2010) M. Mordstein et al.   JOURNAL OF VIROLOGY

Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection In Vivo

(2010) N. A. Jewell et al.   JOURNAL OF VIROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Vesicular Stomatitis Virus Enters Cells through Vesicles Incompletely Coated with Clathrin That Depend upon Actin for Internalization

(2009) David K. Cureton et al.   PLoS Pathogens

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

(2008) Markus Mordstein et al.   PLoS Pathogens

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens