Interferon lambda 4 expression is suppressed by the host during viral infection

Interferon lambda 4 genotypes and resistance-associated variants in patients infected with hepatitis C virus genotypes 1 and 3

(2015) Kai-Henrik Peiffer et al.   HEPATOLOGY

Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance

(2015) Thomas R. O’Brien et al.   JOURNAL OF HEPATOLOGY

Expression of Interferon Lambda 4 Is Associated with Reduced Proliferation and Increased Cell Death in Human Hepatic Cells

(2015) Olusegun O. Onabajo et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Interferon-λ4 is a cell-autonomous type III interferon associated with pre-treatment hepatitis C virus burden

(2015) Yi-Fan Lu et al.   VIROLOGY

IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance

(2015) Yi-Fan Lu et al.   Scientific Reports

Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a Compartmentalized Mucosal Defense System that Restricts Enteric Virus Infections

(2015) Tanel Mahlakõiv et al.   PLoS Pathogens

Emerging functions of alternative splicing coupled with nonsense-mediated decay

(2014) Fursham M. Hamid et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interferon-  cures persistent murine norovirus infection in the absence of adaptive immunity

(2014) T. J. Nice et al.   SCIENCE

Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

(2014) Ewa Terczyńska-Dyla et al.   Nature Communications

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses

(2013) Ole J Hamming et al.   EMBO JOURNAL

IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction

(2013) Stéphanie Bibert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFNL4-ΔG Genotype Is Associated With Slower Viral Clearance in Hepatitis C, Genotype-1 Patients Treated With Sofosbuvir and Ribavirin

(2013) Eric G. Meissner et al.   JOURNAL OF INFECTIOUS DISEASES

Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus

(2013) Peter V. Aka et al.   JOURNAL OF INFECTIOUS DISEASES

Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C

(2013) David Booth et al.   NATURE GENETICS

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus–induced microRNAs

(2013) Adelle P McFarland et al.   NATURE IMMUNOLOGY

New gene IFNL4 is associated with impaired clearance of HCV

(2013) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

Interferon-λ4 (IFNL4) Transcript Expression in Human Liver Tissue Samples

(2013) Ahmad Amanzada et al.   PLoS One

Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells

(2013) Amy E. L. Stone et al.   PLoS Pathogens

Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia

(2013) Stefania Crotta et al.   PLoS Pathogens

IFN-λs

(2011) Sergei V Kotenko   CURRENT OPINION IN IMMUNOLOGY

Ending the message: poly(A) signals then and now

(2011) N. J. Proudfoot   GENES & DEVELOPMENT

IFN-  determines the intestinal epithelial antiviral host defense

(2011) J. Pott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measuring antiviral activity of benzimidazole molecules that alter IRES RNA structure with an infectious hepatitis C virus chimera expressing Renilla luciferase

(2010) Shuanghu Liu et al.   ANTIVIRAL RESEARCH

Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study

(2010) Andri Rauch et al.   GASTROENTEROLOGY

Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

(2010) M. Mordstein et al.   JOURNAL OF VIROLOGY

Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection In Vivo

(2010) N. A. Jewell et al.   JOURNAL OF VIROLOGY

IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity

(2010) Mehul S. Suthar et al.   PLoS Pathogens

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Human interferon-λ3 is a potent member of the type III interferon family

(2008) C Dellgren et al.   GENES AND IMMUNITY

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

(2008) Markus Mordstein et al.   PLoS Pathogens