New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases

P66Shc signals to age

(2016) Mirella Trinei et al.   Aging-US

NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?

(2015) Christine Hirschhäuser et al.   ANTIOXIDANTS & REDOX SIGNALING

The p66ShcA adaptor protein regulates healing after myocardial infarction

(2015) Anton Baysa et al.   BASIC RESEARCH IN CARDIOLOGY

High-dose alcohol induces reactive oxygen species-mediated apoptosis via PKC-β/p66Shc in mouse primary cardiomyocytes

(2015) Yuehong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Overview

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans

(2015) Stefano Ciciliot et al.   DIABETOLOGIA

Post-ischaemic silencing of p66Shcreduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke

(2015) R.D. Spescha et al.   EUROPEAN HEART JOURNAL

17β-Estradiol Abrogates Apoptosis Inhibiting PKCδ, JNK, and p66Shc Activation in C2C12 Cells

(2015) Anabela La Colla et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

(2015) Paolo Bernardi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Trichostatin A Modulates Angiotensin II-induced Vasoconstriction and Blood Pressure Via Inhibition of p66shc Activation

(2015) Gun Kang et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Exercise modulates liver cellular and mitochondrial proteins related to quality control signaling

(2015) E. Santos-Alves et al.   LIFE SCIENCES

Sulfhydration of p66Shc at Cysteine59 Mediates the Antioxidant Effect of Hydrogen Sulfide

(2014) Zhi-Zhong Xie et al.   ANTIOXIDANTS & REDOX SIGNALING

Canonical Wnt Signaling Induces Vascular Endothelial Dysfunction via p66 Shc -Regulated Reactive Oxygen Species

(2014) Ajit Vikram et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

P66Shc mediates increased platelet activation and aggregation in hypercholesterolemia

(2014) Santosh Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein kinase C-beta: An emerging connection between nutrient excess and obesity

(2014) Neil K. Mehta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning

(2014) Ioanna Andreadou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Cardiac Mitochondria and Reactive Oxygen Species Generation

(2014) Yeong-Renn Chen et al.   CIRCULATION RESEARCH

Epigenetic Reprogramming in Atherosclerosis

(2014) Vincenzo Grimaldi et al.   Current Atherosclerosis Reports

Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways

(2014) Alexander Akhmedov et al.   EUROPEAN HEART JOURNAL

Exercise mitigates diclofenac-induced liver mitochondrial dysfunction

(2014) Estela Santos-Alves et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation

(2014) Jeroen Frijhoff et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prolonged swimming promotes cellular oxidative stress and p66Shc phosphorylation, but does not induce oxidative stress in mitochondria in the rat heart

(2014) W. Ziolkowski et al.   FREE RADICAL RESEARCH

The expression of p66shc in peripheral blood monocytes is increased in patients with coronary heart disease and correlated with endothelium-dependent vasodilatation

(2014) Qin Miao et al.   HEART AND VESSELS

Enhanced age-dependent cerebrovascular dysfunction is mediated by adaptor protein p66Shc

(2014) Yi Shi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mitochondrial reactive oxygen species production and elimination

(2014) Alexander Nickel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Monoamine oxidases as sources of oxidants in the heart

(2014) Nina Kaludercic et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

An overview of mechanisms of redox signaling

(2014) Henry Jay Forman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Propofol Protects Against Angiotensin II-Induced Mouse Hippocampal HT22 Cells Apoptosis Via Inhibition of p66Shc Mitochondrial Translocation

(2014) Minmin Zhu et al.   NEUROMOLECULAR MEDICINE

PKCδPromotes High Glucose Induced Renal Tubular Oxidative Damage via Regulating Activation and Translocation of p66Shc

(2014) Panai Song et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Dual Role of Endothelial Nitric Oxide Synthase in Oxidized LDL-Induced, p66Shc-Mediated Oxidative Stress in Cultured Human Endothelial Cells

(2014) Yi Shi et al.   PLoS One

Reversible Blockade of Complex I or Inhibition of PKCβ Reduces Activation and Mitochondria Translocation of p66Shc to Preserve Cardiac Function after Ischemia

(2014) Meiying Yang et al.   PLoS One

The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism

(2014) M. A. Soliman et al.   Science Signaling

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nitric Oxide, Oxidative Stress, andp66ShcInterplay in Diabetic Endothelial Dysfunction

(2014) Alessandra Magenta et al.   Biomed Research International

Hypoxia-Inducible Factor 1 and Cardiovascular Disease

(2013) Gregg L. Semenza   Annual Review of Physiology

Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1

(2013) M. Albiero et al.   DIABETES

Redox modification of proteins as essential mediators of CNS autophagy and mitophagy

(2013) Britney Lizama-Manibusan et al.   FEBS LETTERS

SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres

(2013) Doris Mangiaracina Benbrook et al.   INVESTIGATIONAL NEW DRUGS

p66Shc regulates vesicle-mediated secretion in mast cells by affecting F-actin dynamics

(2013) Giulia Masi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

P66Shc-rac1 pathway-mediated ROS production and cell migration is downregulated by ascorbic acid

(2013) Deeba Kirmani et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Fish-oil emulsion (omega-3 polyunsaturated fatty acids) attenuates acute lung injury induced by intestinal ischemia–reperfusion through Adenosine 5′-monophosphate-activated protein kinase–sirtuin1 pathway

(2013) Huirong Jing et al.   JOURNAL OF SURGICAL RESEARCH

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Chronic nicotine exposure augments renal oxidative stress and injury through transcriptional activation of p66shc

(2013) I. Arany et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

β-Amyloid-evoked Apoptotic Cell Death is Mediated Through MKK6–p66shc Pathway

(2013) Muneesa Bashir et al.   NEUROMOLECULAR MEDICINE

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration

(2013) Costanza Savino et al.   Oxidative Medicine and Cellular Longevity

Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice

(2013) Xiaomei Xu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l ‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability

(2013) Yuyan Xiong et al.   Journal of the American Heart Association

Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction

(2012) Young-Rae Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac mitochondrial dysfunction during hyperglycemia—The role of oxidative stress and p66Shc signaling

(2012) Catia V. Diogo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats

(2012) Yu-Si Cheng et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Aging, Atherosclerosis, and IGF-1

(2012) Y. Higashi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate

(2012) T. Finkel   Science Signaling

Protein Kinase C Inhibition Ameliorates Posttransplantation Preservation Injury in Rat Renal Transplants

(2012) Tom Florian Fuller et al.   TRANSPLANTATION

The p66Shcknockout mice are short lived under natural condition

(2011) Marco Giorgio et al.   AGING CELL

Mitochondrial Thiols in Antioxidant Protection and Redox Signaling: Distinct Roles for Glutathionylation and Other Thiol Modifications

(2011) Michael P. Murphy   ANTIOXIDANTS & REDOX SIGNALING

Oxidized Low-Density Lipoprotein Activates p66 Shc via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1, Protein Kinase C-β, and c-Jun N-Terminal Kinase Kinase in Human Endothelial Cells

(2011) Yi Shi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease

(2011) Fabian C. Franzeck et al.   ATHEROSCLEROSIS

Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction

(2011) Sang Ki Lee et al.   CARDIOVASCULAR RESEARCH

Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc

(2011) Cuk-Seong Kim et al.   CARDIOVASCULAR RESEARCH

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

(2011) Dao-Fu Dai et al.   CIRCULATION RESEARCH

The Shc locus regulates insulin signaling and adiposity in mammals

(2010) Alexey A. Tomilov et al.   AGING CELL

Postconditioning and protection from reperfusion injury: where do we stand? * Position Paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology

(2010) M. Ovize et al.   CARDIOVASCULAR RESEARCH

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

The p66shc Gene Expression in Peripheral Blood Monocytes Is Increased in Patients With Coronary Artery Disease

(2010) Yoshihiro Noda et al.   CLINICAL CARDIOLOGY

The Redox Enzyme p66Shc Contributes to Diabetes and Ischemia-Induced Delay in Cutaneous Wound Healing

(2010) G. P. Fadini et al.   DIABETES

Resveratrol regulates p66Shc activation in HaCaT cells

(2010) Gabriella Fabbrocini et al.   EXPERIMENTAL DERMATOLOGY

Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity

(2010) Tohru Yamamori et al.   FREE RADICAL RESEARCH

Essential Role of the Redox-Sensitive Kinase p66shc in Determining Energetic and Oxidative Status and Cell Fate in Neuronal Preconditioning

(2010) J. E. Brown et al.   JOURNAL OF NEUROSCIENCE

Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance

(2010) S. C. Ranieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cardioprotective effects elicited by p66Shc ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury

(2009) Andrea Carpi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

p66Shc Links α 1 -Adrenergic Receptors to a Reactive Oxygen Species-Dependent AKT-FOXO3A Phosphorylation Pathway in Cardiomyocytes

(2009) Jianfen Guo et al.   CIRCULATION RESEARCH

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial dysfunction is associated with a pro-apoptotic cellular environment in senescent cardiac muscle

(2009) Vladimir Ljubicic et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation

(2008) Tyler H. Rork et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

p66ShcDeletion Confers Vascular Protection in Advanced Atherosclerosis in Hypercholesterolemic Apolipoprotein E Knockout Mice

(2008) Ines Martin-Padura et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH

Alteration of p66shc is associated with endothelial dysfunction in the abdominal aortic coarctation of rats

(2008) Sang Ki Lee et al.   FEBS LETTERS

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

(2008) Ina Berniakovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p66shc Negatively Regulates Insulin-Like Growth Factor I Signal Transduction via Inhibition of p52shc Binding to Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Leading to Impaired Growth Factor Receptor-Bound Protein-2 Membrane Recruitment

(2008) Gang Xi et al.   MOLECULAR ENDOCRINOLOGY

Final Common Molecular Pathways of Aging and Cardiovascular Disease

(2007) Francesco Cosentino et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY