Canonical Wnt Signaling Induces Vascular Endothelial Dysfunction via p66 Shc -Regulated Reactive Oxygen Species

Wnt/β-Catenin Signaling Regulates the Proliferation and Differentiation of Mesenchymal Progenitor Cells through the p53 Pathway

(2014) Xu Peng et al.   PLoS One

LXR agonism improves TNF-α-induced endothelial dysfunction in the absence of its cholesterol-modulating effects

(2013) Frank Spillmann et al.   ATHEROSCLEROSIS

LRP6 Enhances Glucose Metabolism by Promoting TCF7L2-Dependent Insulin Receptor Expression and IGF Receptor Stabilization in Humans

(2013) Rajvir Singh et al.   Cell Metabolism

WNT signaling underlies the pathogenesis of neuropathic pain in rodents

(2013) Yan-Kai Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells

(2013) Akihiko Hiyama et al.   ARTHRITIS RESEARCH & THERAPY

Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction

(2012) Young-Rae Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nitrosative Stress Plays an Important Role in Wnt Pathway Activation in Diabetic Retinopathy

(2012) Qiuping Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signaling

(2012) Seheli Kajla et al.   FASEB JOURNAL

Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease

(2011) Fabian C. Franzeck et al.   ATHEROSCLEROSIS

Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells

(2011) Weimin Qiu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc

(2011) Cuk-Seong Kim et al.   CARDIOVASCULAR RESEARCH

Wnt Signaling Mediates Pathological Vascular Growth in Proliferative Retinopathy

(2011) Jing Chen et al.   CIRCULATION

Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction

(2011) Shuang Zhou et al.   CIRCULATION RESEARCH

High-fat Diet Increases and the Polyphenol, S17834, Decreases Acetylation of the Sirtuin-1–dependent Lysine-382 on p53 and Apoptotic Signaling in Atherosclerotic Lesion–prone Aortic Endothelium of Normal Mice

(2011) Shanqin Xu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling

(2011) N. H. Kim et al.   Science Signaling

The Wnt/beta-catenin pathway is activated during advanced arterial aging in humans

(2010) Alexandre Marchand et al.   AGING CELL

p53 Impairs Endothelial Function by Transcriptionally Repressing Kruppel-Like Factor 2

(2010) Ajay Kumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Wnt4/β-Catenin Signaling Induces VSMC Proliferation and Is Associated With Intimal Thickening

(2010) Aikaterini Tsaousi et al.   CIRCULATION RESEARCH

The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy

(2010) T. Zhou et al.   DIABETOLOGIA

NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon

(2010) Nicolas Coant et al.   MOLECULAR AND CELLULAR BIOLOGY

Dickkopf-1 Enhances Inflammatory Interaction Between Platelets and Endothelial Cells and Shows Increased Expression in Atherosclerosis

(2009) Thor Ueland et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways

(2009) Ivana Samarzija et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton

(2009) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway

(2009) Ethan David Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT1 deacetylates APE1 and regulates cellular base excision repair

(2009) Tohru Yamamori et al.   NUCLEIC ACIDS RESEARCH

Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variant

(2009) R. Sarzani et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Wnt Signaling from Development to Disease: Insights from Model Systems

(2009) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

P53 Impairs Endothelium-Dependent Vasomotor Function Through Transcriptional Upregulation of P66shc

(2008) Cuk-Seong Kim et al.   CIRCULATION RESEARCH

p66ShcDeletion Confers Vascular Protection in Advanced Atherosclerosis in Hypercholesterolemic Apolipoprotein E Knockout Mice

(2008) Ines Martin-Padura et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

(2008) Ina Berniakovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY