Article
Biochemistry & Molecular Biology
Sivanan Sivasinprasasn, Naruemon Wikan, Jiraporn Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus
Summary: The study revealed that the combined application of PAVA and RSV can inhibit ox-LDL-induced inflammatory responses, decrease activation of NF-KB/NLRP3 pathway, reduce recruitment of monocytes, and ameliorate impairment of cell-cell junctions, offering a novel mechanism for the treatment of cardiovascular diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Multidisciplinary Sciences
Radhia Hamdi, Amana Saadallah-Kallel, Slima Ferchichi-Trimeche, Raja Mokdad-Gargouri, Abdelhedi Miled, Bachir Benarba
Summary: The study found that DNA hypomethylation of the p66shc promoter in chronic renal failure patients is correlated with oxidative and inflammatory stress as well as disease stages.
Article
Rheumatology
Ricardo Rodriguez-Calvo, Montse Guardiola, Iris Oliva, Hugo Arrando, Idoia Arranz, Anna Ferre, Paula Pellicer, Sandra Parra, Josep Ribalta, Antoni Castro
Summary: The study found that LDL from active SLE patients had greater proatherogenic effects on endothelial cells compared to LDL from inactive SLE patients at the same LDL concentration.
Article
Multidisciplinary Sciences
Ying-Shao Lin, Ching-Kuan Liu, Hsiang-Chun Lee, Mei-Chuan Chou, Liang-Yin Ke, Chu-Huang Chen, Shiou-Lan Chen
Summary: The study found that long-term exposure to electronegative VLDL from patients with metabolic syndrome can lead to increased levels of inflammatory factors and amyloid beta in the brain, affecting cognitive function.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Jaylen Hudson, Laszlo Farkas
Summary: Pulmonary artery hypertension (PAH) is now recognized as a pulmonary vascular disease with severe endothelial dysfunction, with epigenetic modifications playing a key role in its pathogenesis. Understanding endothelial cell regulation mechanisms and investigating epigenetic changes may lead to future therapeutic advancements in treating PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Rita Castro, Courtney A. Whalen, Sean Gullette, Floyd J. Mattie, Cristina Florindo, Sandra G. Heil, Neil K. Huang, Thomas Neuberger, A. Catharine Ross
Summary: This pilot study investigated the effects of mild HHcy induced by nutritional manipulation of the methionine metabolism on disease progression and specific epigenetic changes in mice. Results showed the presence of nutritional ketosis in KD and LMKD mice, with mild HHcy only detected in LMKD-fed mice. Significantly different levels of some markers were observed between control mice and the other two groups, suggesting potential factors influencing the progression of HHcy. Further studies with a larger sample size are needed to confirm these preliminary observations.
Article
Biochemistry & Molecular Biology
Feng-Yen Lin, Yi-Wen Lin, Chun-Ming Shih, Shing-Jong Lin, Yu-Tang Tung, Chi-Yuan Li, Yung-Hsiang Chen, Cheng-Yen Lin, Yi-Ting Tsai, Chun-Yao Huang
Summary: Therapeutic elevation of high-density lipoprotein (HDL) is believed to reduce atherosclerosis in patients with dyslipidemia. However, clinical practice shows that the concentration of HDL does not determine its function, which is instead influenced by specific structural components. The relative HDL (rHDL) index has been identified as a predictor of HDL functionality, with dysfunctional HDL failing to protect damaged endothelial progenitor cells (EPCs), highlighting the importance of HDL structure in its function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
John E. Le Lay, Qun Du, Minal B. Mehta, Nicholas Bhagroo, B. Timothy Hummer, Judith Falloon, Glenn Carlson, Anton Rosenbaum, ChaoYu Jin, Holly Kimko, Lan-Feng Tsai, Steven Novick, Bill Cook, David Han, Chang Yeop Han, Tomas Vaisar, Alan Chait, Sotirios K. Karathanasis, Christopher J. Rhodes, Boaz Hirshberg, Melissa M. Damschroder, Judith Hsia, Joseph S. Grimsby
Summary: HDL levels play a crucial role in cardiovascular disease, and inhibiting endothelial lipase can increase HDL-C, improve lipoprotein profiles, and reduce cardiovascular risk when combined with other medications.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Medicine, Research & Experimental
Abdul Waheed Khan, Francesco Paneni, Karin A. M. Jandeleit-Dahm
Summary: Atherosclerosis is a disease affecting large and medium arteries, leading to life-threatening cerebrovascular and cardiovascular consequences. Single-cell RNA sequencing has identified disease-related cell-specific transcriptomic profiles and new sub-populations of cells. Vascular cells undergo specific transcriptional changes throughout the disease course, with epigenetics playing a crucial role in regulating cellular identity.
Article
Cardiac & Cardiovascular Systems
Feroz Ahmad, Robert D. Mitchell, Tom Houben, Angela Palo, Tulasi Yadati, Andrew J. Parnell, Ketan Patel, Ronit Shiri-Sverdlov, David S. Leake
Summary: The study shows that cysteamine can induce regression of atherosclerotic lesions in LDL receptor-deficient mice, improve lesion stability, reduce oxidized phospholipids, decrease liver lipid levels and expression of specific proteins and cytokines, as well as enhance skeletal muscle function. No changes were observed in plasma lipid concentrations. This suggests that lysosomal oxidation inhibition with antioxidants targeted at lysosomes may be a promising therapy for atherosclerosis in patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Hitomi Ohinata, Takashi Obama, Tomohiko Makiyama, Yuichi Watanabe, Hiroyuki Itabe
Summary: This study found that high-density lipoproteins (HDL) partially decreased neutrophil extracellular trap (NET) formation induced by copper-oxidized low-density lipoprotein (oxLDL). It was also discovered that oxidized phosphatidylcholines and lysophosphatidylcholine in oxLDL promoted NET formation, which could be completely blocked by native HDL. Furthermore, an electronegative subfraction of LDL, LDL(-), was found to promote NET formation. These findings suggest that plasma lipoproteins and their oxidative modifications play multiple roles in promoting NET formation, and HDL acts as a suppressor of this response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Jolien Fledderus, Byambasuren Vanchin, Marianne G. Rots, Guido Krenning
Summary: Endothelial cell inflammatory activation and dysfunction play crucial roles in atherosclerosis pathophysiology and targeting endothelium could be an effective approach for antiatherogenic therapies. Specific epigenetic enzymes dysregulation, such as EZH2 and SIRT1, may worsen endothelial dysfunction in a pleiotropic manner. Commercially available drugs could be explored clinically to address this hypothesis.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Nutrition & Dietetics
Ewa Wieczorek, Agnieszka Cwiklinska, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwinska, Maciej Jankowski
Summary: This study aimed to evaluate the impact of hypercholesterolemia and hypertriglyceridemia on the efficiency of lipoprotein lipase-mediated VLDL-triglyceride lipolysis, as well as the role of HDL in this process. The results showed that VLDL from patients with hypercholesterolemia and hypertriglyceridemia are more resistant to lipolysis, with HDL helping to enhance the efficiency of lipolysis in these groups.
Review
Cell Biology
Yukihito Higashi
Summary: Dyslipidemia is linked to endothelial dysfunction leading to atherosclerosis and cardiovascular complications. Breaking the progression from endothelial dysfunction to cardiovascular complications is clinically important in dyslipidemia patients. Lipid-lowering therapy improves endothelial function in dyslipidemia patients. The relationships of components of a lipid profile with endothelial function, such as LDL cholesterol, HDL cholesterol, and triglycerides, are complex. This review focuses on exploring their roles.
Article
Biology
Hikaru Sato, Juan Santos-Gonzalez, Claudia Koehler
Summary: The study reveals that maternal alleles marked by H3K27me3 in Arabidopsis endosperm are targeted by the H3K27me3 demethylase REF6 and become activated during germination, while other maternal alleles marked by H3K27me3, H3K9me2, and CHG methylation are protected from REF6 targeting and remain silenced. This suggests that combinations of different repressive epigenetic modifications play a role in modulating access of REF6 and timing key adaptive traits.
Editorial Material
Cardiac & Cardiovascular Systems
Santosh Kumar
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Shuyu Piao, Harsha Nagar, Seonhee Kim, Ikjun Lee, Su-jeong Choi, Taehee Kim, Byeong Hwa Jeon, Cuk-Seong Kim
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Chemistry, Medicinal
Harsha Nagar, Shin Kwang Kang, Si Wan Choi, Hee-Jung Song, Su-Jeong Choi, Shuyu Piao, Seonhee Kim, Ikjun Lee, Cuk-Seong Kim
NATURAL PRODUCT COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Ikjun Lee, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Byeong Hwa Jeon, Shuyu Piao, Cuk-Seong Kim
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Ravinder Reddy Gaddam, Veronica Peotta Jacobsen, Young-Rae Kim, Mohanad Gabani, Julia S. Jacobs, Karishma Dhuri, Santosh Kumar, Modar Kassan, Qiuxia Li, Raman Bahal, Robert Roghair, Kaikobad Irani, Ajit Vikram
SCIENTIFIC REPORTS
(2020)
Review
Cardiac & Cardiovascular Systems
Karima Ait-Aissa, Quynh My Nguyen, Mohanad Gabani, Adam Kassan, Santosh Kumar, Soo-Kyoung Choi, Alexis A. Gonzalez, Tahsin Khataei, Amal M. Sahyoun, Cheng Chen, Modar Kassan
CARDIOVASCULAR DIABETOLOGY
(2020)
Review
Chemistry, Medicinal
Shravan Kumar Uppulapu, Md Jahangir Alam, Santosh Kumar, Sanjay Kumar Banerjee
Summary: This review summarizes the structural and pharmacological functions of indazole derivatives that have shown efficacy against cardiovascular pathologies in experimental settings.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jitendra Kumar, Santosh Kumar
Summary: Sirtuin1, a nutrient-sensitive histone deacetylase, serves as a key regulator of organismal lifespan and metabolic regulation. It also plays a direct role in controlling cardiovascular pathophysiology, particularly in vascular endothelial homeostasis by regulating inflammatory mediators, oxidants, and essential transcription factors. The complexity of Sirtuin1's expression and function being governed by its target proteins underscores the importance of understanding its tissue specificity for potential therapeutic interventions.
Article
Biochemistry & Molecular Biology
Ikjun Lee, Shuyu Piao, Seonhee Kim, Harsha Nagar, Su-Jeong Choi, Byeong Hwa Jeon, Sang-Ha Oh, Kaikobad Irani, Cuk-Seong Kim
Summary: The deletion of CRIF1 in endothelial cells led to increased homocysteine accumulation, decreased levels of folate cycle intermediates, and disrupted DHFR expression and activity. Supplementation with folic acid could not reverse this effect, but overexpression of DHFR reduced homocysteine accumulation in CRIF1 knockdown cells.
Article
Biochemistry & Molecular Biology
Su-jeong Choi, Harsha Nagar, Jun Wan Lee, Seonhee Kim, Ikjun Lee, Shuyu Piao, Byeong Hwa Jeon, Cuk-Seong Kim
Summary: This study found that IDH2 deficiency induced increased expression of SDC2 in endothelial cells, with MMP7 and TGF-beta signaling playing regulatory roles. UTI could reverse the increase in SDC2, MMP7, and TGF-beta signaling caused by IDH2 deficiency.
Article
Integrative & Complementary Medicine
Seonhee Kim, Harsha Nagar, Ikjun Lee, Su-Jeong Choi, Shuyu Piao, Byeong Hwa Jeon, Shin Kwang Kang, Hee-Jung Song, Cuk-Seong Kim
Summary: Breast cancer is a common and deadly disease, especially in triple-negative breast cancer (TNBC) cases. This study investigates the potential of sericite, a natural mineral, as an antitumor agent for TNBC. The results show that sericite can inhibit cell proliferation, induce cell cycle arrest, and promote apoptotic cell death. These findings suggest that sericite could be a potential therapeutic option for TNBC.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biology
Seonhee Kim, Ikjun Lee, Shuyu Piao, Harsha Nagar, Su-Jeong Choi, Young-Rae Kim, Kaikobad Irani, Byeong Hwa Jeon, Cuk-Seong Kim
Summary: It has been found that miR204 plays a role in promoting the development of non-alcoholic fatty liver disease by regulating hepatic fatty acid metabolism and inflammation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuyu Piao, Ikjun Lee, Seonhee Kim, Hyewon Park, Harsha Nagar, Su-Jeong Choi, Giang-Huong Vu, Minsoo Kim, Eun-Ok Lee, Byeong-Hwa Jeon, Dong Woon Kim, Youngduk Seo, Cuk-Seong Kim
Summary: This study investigates the role of CRIF1 deficiency in modulating mitochondrial oxidative phosphorylation (OXPHOS) system dysfunction and its antitumor effects in MCF-7 breast cancer cells. CRIF1 silencing decreases the assembly of mitochondrial OXPHOS complexes, leading to mitochondrial dysfunction and elevated reactive oxygen species (ROS) levels. Inhibition of CRIF1 suppresses cell proliferation and inhibits cell migration in MCF-7 cells, and intratumoral injection of CRIF1 siRNA nanoparticles inhibits tumor growth in MCF-7 xenograft mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ikjun Lee, Shuyu Piao, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Minsoo Kim, Giang-Huong Vu, Byeong-Hwa Jeon, Cuk-Seong Kim
Summary: Endothelial senescence impairs vascular function and is a major factor in age-related vasculature diseases. IDH2 is involved in the production of alpha-ketoglutarate and preservation of mitochondrial function. However, the mechanism and regulation of IDH2 in endothelial senescence have not been fully understood.
Article
Multidisciplinary Sciences
Harsha Nagar, Seonhee Kim, Ikjun Lee, Su-Jeong Choi, Shuyu Piao, Byeong Hwa Jeon, Minho Shong, Cuk-Seong Kim
Summary: RhoGDI2 and ADM2 play crucial roles in the migration of CRIF1-deficient endothelial cells, with CRIF1 affecting endothelial cell migration through the Akt-CREB signaling pathway.