Uncovering the Pharmacological Mechanism of Stemazole in the Treatment of Neurodegenerative Diseases Based on a Network Pharmacology Approach
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Title
Uncovering the Pharmacological Mechanism of Stemazole in the Treatment of Neurodegenerative Diseases Based on a Network Pharmacology Approach
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 2, Pages 427
Publisher
MDPI AG
Online
2020-01-10
DOI
10.3390/ijms21020427
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Note: Only part of the references are listed.- Treatment of Parkinson’s Disease through Personalized Medicine and Induced Pluripotent Stem Cells
- (2019) Theo Stoddard-Bennett et al. Cells
- g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)
- (2019) Uku Raudvere et al. NUCLEIC ACIDS RESEARCH
- Pharmacokinetics and absolute oral bioavailability of stemazole by UPLC–MS/MS and its bio‐distribution through tritium labeling
- (2019) Huajun Li et al. Drug Testing and Analysis
- Stemazole promotes survival and preserves stemness in human embryonic stem cells
- (2018) Ying Sun et al. FEBS Journal
- The Parkinson Pandemic—A Call to Action
- (2018) E. Ray Dorsey et al. JAMA Neurology
- Reverse Screening Methods to Search for the Protein Targets of Chemopreventive Compounds
- (2018) Hongbin Huang et al. Frontiers in Chemistry
- Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs
- (2018) Delphine Charvin et al. NATURE REVIEWS DRUG DISCOVERY
- The Comparative Toxicogenomics Database: update 2019
- (2018) Allan Peter Davis et al. NUCLEIC ACIDS RESEARCH
- A Systems-Level Analysis of Mechanisms of Platycodon grandiflorum Based on A Network Pharmacological Approach
- (2018) Musun Park et al. MOLECULES
- UniProt: a worldwide hub of protein knowledge
- (2018) NUCLEIC ACIDS RESEARCH
- RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy
- (2018) Stephen K Burley et al. NUCLEIC ACIDS RESEARCH
- A Novel Non-Apoptotic Role of Procaspase-3 in the Regulation of Mitochondrial Biogenesis Activators
- (2017) Ji-Soo Kim et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends
- (2017) Sergey O. Bachurin et al. MEDICINAL RESEARCH REVIEWS
- Network-based Approaches in Pharmacology
- (2017) Baptiste Boezio et al. Molecular Informatics
- PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database
- (2017) Xia Wang et al. NUCLEIC ACIDS RESEARCH
- DrugBank 5.0: a major update to the DrugBank database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- (−)-P7C3-S243 Protects a Rat Model of Alzheimer’s Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia
- (2017) Jaymie R. Voorhees et al. BIOLOGICAL PSYCHIATRY
- TargetNet: a web service for predicting potential drug–target interaction profiling via multi-target SAR models
- (2016) Zhi-Jiang Yao et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Ageing, neurodegeneration and brain rejuvenation
- (2016) Tony Wyss-Coray NATURE
- Neuroprotective effects of stemazole in the MPTP-induced acute model of Parkinson’s disease: Involvement of the dopamine system
- (2016) Zhirui Guo et al. NEUROSCIENCE LETTERS
- DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants
- (2016) Janet Piñero et al. NUCLEIC ACIDS RESEARCH
- Drug development in Alzheimer’s disease: the path to 2025
- (2016) Jeffrey Cummings et al. Alzheimers Research & Therapy
- DPDR-CPI, a server that predicts Drug Positioning and Drug Repositioning via Chemical-Protein Interactome
- (2016) Heng Luo et al. Scientific Reports
- Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice
- (2015) Qiong Zhou et al. ANNALS OF NEUROLOGY
- CytoNCA: A cytoscape plugin for centrality analysis and evaluation of protein interaction networks
- (2015) Yu Tang et al. BIOSYSTEMS
- 2015 Update on Parkinson disease
- (2015) H. H. FERNANDEZ CLEVELAND CLINIC JOURNAL OF MEDICINE
- Parkinson's disease
- (2015) Lorraine V Kalia et al. LANCET
- The promise of stem cells in the therapy of Alzheimer’s disease
- (2015) Chunmei Yue et al. Translational Neurodegeneration
- Development of stem cell-based therapy for Parkinson’s disease
- (2015) Fabin Han et al. Translational Neurodegeneration
- Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neurodegenerative diseases
- (2014) Faraz Ahmad et al. FREE RADICAL BIOLOGY AND MEDICINE
- 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis
- (2014) Orhan Tansel Korkmaz et al. NEUROSCIENCE LETTERS
- STRING v10: protein–protein interaction networks, integrated over the tree of life
- (2014) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury
- (2014) Terry C. Yin et al. Cell Reports
- Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: Protective role of vitamin E
- (2014) E. Giraldo et al. Redox Biology
- ChemMapper: a versatile web server for exploring pharmacology and chemical structure association based on molecular 3D similarity method
- (2013) Jiayu Gong et al. BIOINFORMATICS
- Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease
- (2013) M. Jiang et al. HUMAN MOLECULAR GENETICS
- 7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease
- (2013) Zhentao Zhang et al. NEUROPSYCHOPHARMACOLOGY
- Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease
- (2012) H. De Jesus-Cortes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthesis and biological evaluation of a novel human stem/progenitor cells proliferation activator: 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl) thiosemicarbazide (Stemazole)
- (2011) Ying Sun et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Therapeutic efficacy of stemazole in a beta-amyloid injection rat model of Alzheimer's disease
- (2011) Mei Han et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Epidemiology of Alzheimer disease
- (2011) Christiane Reitz et al. Nature Reviews Neurology
- DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical–protein interactome
- (2011) Heng Luo et al. NUCLEIC ACIDS RESEARCH
- Pathological roles of MAPK signaling pathways in human diseases
- (2010) Eun Kyung Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Discovery of a Proneurogenic, Neuroprotective Chemical
- (2010) Andrew A. Pieper et al. CELL
- JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities
- (2010) Sidharth Mehan et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Towards a knowledge-based Human Protein Atlas
- (2010) Mathias Uhlen et al. NATURE BIOTECHNOLOGY
- Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
- (2010) Marcello D'Amelio et al. NATURE NEUROSCIENCE
- A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
- (2010) S.-W. Jang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
- (2009) Garrett M. Morris et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease
- (2008) Natalia Louneva et al. AMERICAN JOURNAL OF PATHOLOGY
- Network pharmacology: the next paradigm in drug discovery
- (2008) Andrew L Hopkins Nature Chemical Biology
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