Treatment of Parkinson’s Disease through Personalized Medicine and Induced Pluripotent Stem Cells

Stem cells and regenerative medicine for neural repair

(2018) Jun Takahashi   CURRENT OPINION IN BIOTECHNOLOGY

Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease

(2018) Yu-Kai Wang et al.   Stem Cell Reports

Parkinson’s Disease: From Pathogenesis to Pharmacogenomics

(2017) Ramón Cacabelos   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Personalized medicine in Parkinson's disease: Time to be precise

(2017) Nataliya Titova et al.   MOVEMENT DISORDERS

Trials of embryonic stem cells to launch in China

(2017) David Cyranoski   NATURE

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017) Michiko Mandai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Understanding Parkinson’s Disease through the Use of Cell Reprogramming

(2017) Rebecca Playne et al.   Stem Cell Reviews and Reports

MHC matching improves engraftment of iPSC-derived neurons in non-human primates

(2017) Asuka Morizane et al.   Nature Communications

Understanding Parkinson’s Disease through the Use of Cell Reprogramming

(2017) Rebecca Playne et al.   Stem Cell Reviews and Reports

HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease

(2017) Samuel E. Marsh et al.   Stem Cell Reports

An updated review of Parkinson's disease genetics and clinicopathological correlations

(2016) M. Ferreira et al.   ACTA NEUROLOGICA SCANDINAVICA

Cell type of origin influences iPSC generation and differentiation to cells of the hematoendothelial lineage

(2016) Jitrada Phetfong et al.   CELL AND TISSUE RESEARCH

LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?

(2016) Jean-Marc Taymans et al.   Current Neuropharmacology

Advances in understanding genomic markers and pharmacogenetics of Parkinson’s disease

(2016) Félix Javier Jiménez-Jiménez et al.   Expert Opinion on Drug Metabolism & Toxicology

How close are we to individualized medicine for Parkinson’s disease?

(2016) Hee Jin Kim et al.   Expert Review of Neurotherapeutics

Deep brain stimulation mechanisms: the control of network activity via neurochemistry modulation

(2016) Cameron C. McIntyre et al.   JOURNAL OF NEUROCHEMISTRY

Current and experimental treatments of Parkinson disease: A guide for neuroscientists

(2016) Wolfgang Oertel et al.   JOURNAL OF NEUROCHEMISTRY

The hidden sister of motor fluctuations in Parkinson's disease: A review on nonmotor fluctuations

(2016) Raul Martínez-Fernández et al.   MOVEMENT DISORDERS

A decade of transcription factor-mediated reprogramming to pluripotency

(2016) Kazutoshi Takahashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How close are we to individualized medicine for Parkinson’s disease?

(2016) Hee Jin Kim et al.   Expert Review of Neurotherapeutics

Physiotherapy and Occupational Therapy and Mild to Moderate Parkinson Disease

(2016) Nienke M. de Vries et al.   JAMA Neurology

Time Trends in the Incidence of Parkinson Disease

(2016) Rodolfo Savica et al.   JAMA Neurology

Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease

(2015) Alan King Lun Liu et al.   ACTA NEUROPATHOLOGICA

Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease

(2015) Penelope J. Hallett et al.   Cell Stem Cell

Reprogramming of cell fate: epigenetic memory and the erasure of memories past

(2015) B. Nashun et al.   EMBO JOURNAL

Neuropathobiology of non-motor symptoms in Parkinson disease

(2015) Kurt A. Jellinger   JOURNAL OF NEURAL TRANSMISSION

Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study

(2015) Lars Timmermann et al.   LANCET NEUROLOGY

Nonpharmacological treatments for patients with Parkinson's disease

(2015) Bastiaan R. Bloem et al.   MOVEMENT DISORDERS

Cell-based therapies for Parkinson disease—past insights and future potential

(2015) Roger A. Barker et al.   Nature Reviews Neurology

Cell Therapy for Parkinson’s Disease: New Hope from Reprogramming Technologies

(2015) Zhiguo Chen   Aging and Disease

Simultaneous Reprogramming and Gene Correction of Patient Fibroblasts

(2015) Sara E. Howden et al.   Stem Cell Reports

Routes to induced pluripotent stem cells

(2014) Tyson Ruetz et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

(2014) David C. Schöndorf et al.   Nature Communications

Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein

(2014) Xiang Zhang et al.   Applied Sciences-Basel

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

(2013) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

Multiple source current steering – A novel deep brain stimulation concept for customized programming in a Parkinson's disease patient

(2013) Michael T. Barbe et al.   PARKINSONISM & RELATED DISORDERS

Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

(2013) Devika P. Bagchi et al.   PLoS One

Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells

(2012) Blake Byers et al.   Current Neurology and Neuroscience Reports

Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease

(2012) Roger A Barker et al.   LANCET NEUROLOGY

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers

(2012) M. Anheim et al.   NEUROLOGY

Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

(2012) Agnete Kirkeby et al.   Cell Reports

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

Somatic coding mutations in human induced pluripotent stem cells

(2011) Athurva Gore et al.   NATURE

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

A bioinformatic assay for pluripotency in human cells

(2011) Franz-Josef Müller et al.   NATURE METHODS

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

GRNOPC1: the world’s first embryonic stem cell-derived therapy

(2011) Jane Lebkowski   Regenerative Medicine

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

(2011) Michael J. Devine et al.   Nature Communications

Neuroimaging for Lewy body disease: Is the in vivo molecular imaging of α-synuclein neuropathology required and feasible?

(2010) Anthony C. Vernon et al.   BRAIN RESEARCH REVIEWS

Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells

(2010) Christopher A. Fasano et al.   Cell Stem Cell

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity

(2009) Hye Young Heo et al.   EXPERIMENTAL CELL RESEARCH

Lack of functional relevance of isolated cell damage in transplants of Parkinson’s disease patients

(2009) Oliver Cooper et al.   JOURNAL OF NEUROLOGY

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

(2009) Javorina Milosevic et al.   Molecular Neurodegeneration

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

(2009) Noemi FUSAKI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Descending Pathways in Motor Control

(2008) Roger N. Lemon   Annual Review of Neuroscience

Mutation Analysis of the PINK1 Gene in 391 Patients With Parkinson Disease

(2008) Ryuya Kumazawa et al.   ARCHIVES OF NEUROLOGY

Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors

(2008) Sonia Bonilla et al.   GLIA

VMAT2 and dopamine neuron loss in a primate model of Parkinson’s disease

(2008) Ming-Kai Chen et al.   JOURNAL OF NEUROCHEMISTRY

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY

Familial parkinsonism: Study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes

(2008) Kazuko Hasegawa et al.   PARKINSONISM & RELATED DISORDERS