Edible plants for oral delivery of biopharmaceuticals

Enhanced GAD65 production in plants using the MagnICON transient expression system: Optimization of upstream production and downstream processing

(2016) Matilde Merlin et al.   Biotechnology Journal

Enhanced GAD65 production in plants using the MagnICON transient expression system: Optimization of upstream production and downstream processing

(2016) Matilde Merlin et al.   Biotechnology Journal

Low cost industrial production of coagulation factor IX bioencapsulated in lettuce cells for oral tolerance induction in hemophilia B

(2015) Jin Su et al.   BIOMATERIALS

The fusion ofToxoplasma gondiiSAG1 vaccine candidate toLeishmania infantumheat shock protein 83-kDa improves expression levels in tobacco chloroplasts

(2015) Romina M. Albarracín et al.   Biotechnology Journal

Rapid high-yield expression of a candidate influenza vaccine based on the ectodomain of M2 protein linked to flagellin in plants using viral vectors

(2015) Eugenia S. Mardanova et al.   BMC BIOTECHNOLOGY

Prevention of allergic conjunctivitis in mice by a rice-based edible vaccine containing modified Japanese cedar pollen allergens

(2015) Ken Fukuda et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Plants as Factories for Human Pharmaceuticals: Applications and Challenges

(2015) Jian Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Study of the immunogenicity of hepatitis B surface antigen synthesized in transgenic potato plants with increased biosafety

(2015) Elena B. Rukavtsova et al.   JOURNAL OF BIOTECHNOLOGY

Plant-made oral vaccines against human infectious diseases-Are we there yet?

(2015) Hui-Ting Chan et al.   PLANT BIOTECHNOLOGY JOURNAL

Low-cost oral delivery of protein drugs bioencapsulated in plant cells

(2015) Kwang-Chul Kwon et al.   PLANT BIOTECHNOLOGY JOURNAL

Oral delivery of Acid Alpha Glucosidase epitopes expressed in plant chloroplasts suppresses antibody formation in treatment of Pompe mice

(2015) Jin Su et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression of H3N2 nucleoprotein in maize seeds and immunogenicity in mice

(2015) Hartinio N. Nahampun et al.   PLANT CELL REPORTS

Over-expression of the cucumber expansin gene (Cs-EXPA1) in transgenic maize seed for cellulose deconstruction

(2015) Sangwoong Yoon et al.   TRANSGENIC RESEARCH

Oral delivery of wafers made from HBsAg-expressing maize germ induces long-term immunological systemic and mucosal responses

(2015) Celine A. Hayden et al.   VACCINE

The fusion ofToxoplasma gondiiSAG1 vaccine candidate toLeishmania infantumheat shock protein 83-kDa improves expression levels in tobacco chloroplasts

(2015) Romina M. Albarracín et al.   Biotechnology Journal

Plant-Derived Chimeric Virus Particles for the Diagnosis of Primary Sjögren Syndrome

(2015) Elisa Tinazzi et al.   Frontiers in Plant Science

Expression and functional validation of heat-labile enterotoxin B (LTB) and cholera toxin B (CTB) subunits in transgenic rice (Oryza sativa)

(2015) Ho Seob Soh et al.   SpringerPlus

Concentrated Protein Body Product Derived from Rice Endosperm as an Oral Tolerogen for Allergen-Specific Immunotherapy—A New Mucosal Vaccine Formulation against Japanese Cedar Pollen Allergy

(2015) Yuhya Wakasa et al.   PLoS One

Transgenic Production of an Anti HIV Antibody in the Barley Endosperm

(2015) Goetz Hensel et al.   PLoS One

Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cells

(2014) A. Sherman et al.   BLOOD

Production of cecropin A antimicrobial peptide in rice seed endosperm

(2014) Mireia Bundó et al.   BMC PLANT BIOLOGY

Immunological aspects of using plant cells as delivery vehicles for oral vaccines

(2014) Sergio Rosales-Mendoza et al.   Expert Review of Vaccines

Transgenic plants: a 5-year update on oral antipathogen vaccine development

(2014) Marisela Hernández et al.   Expert Review of Vaccines

Challenges in mucosal vaccines for the control of infectious diseases

(2014) T. Azegami et al.   INTERNATIONAL IMMUNOLOGY

Generation of protective immune response against anthrax by oral immunization with protective antigen plant-based vaccine

(2014) Jyotsna Gorantala et al.   JOURNAL OF BIOTECHNOLOGY

Oral delivery of plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to high doses

(2014) Ingrid Lindh et al.   VACCINE

Comparative Evaluation of Recombinant Protein Production in Different Biofactories: The Green Perspective

(2014) Matilde Merlin et al.   Biomed Research International

Alga-Produced Cholera Toxin-Pfs25 Fusion Proteins as Oral Vaccines

(2013) James A. Gregory et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Immunization with an HPV-16 L1-based chimeric virus-like particle containing HPV-16 E6 and E7 epitopes elicits long-lasting prophylactic and therapeutic efficacy in an HPV-16 tumor mice model

(2013) Alberto Monroy-García et al.   ARCHIVES OF VIROLOGY

Optimizing the Yield of Recombinant Pharmaceutical Proteins in Plants

(2013) Richard Twyman et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Farming of Pharmaceutical Proteins Using Plant Suspension Cell and Tissue Cultures

(2013) Stefan Schillberg et al.   CURRENT PHARMACEUTICAL DESIGN

Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection

(2013) Daisuke Tokuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification

(2013) Yoshikazu Yuki et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant species and organ influence the structure and subcellular localization of recombinant glycoproteins

(2013) Elsa Arcalis et al.   PLANT MOLECULAR BIOLOGY

Oral Immunogenicity of Plant-MadeMycobacterium tuberculosisESAT6 and CFP10

(2013) Elena A. Uvarova et al.   Biomed Research International

Oral immunogenicity of potato-derived antigens to Mycobacterium tuberculosis in mice

(2012) Y. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Mechanism of oral tolerance induction to therapeutic proteins

(2012) Xiaomei Wang et al.   ADVANCED DRUG DELIVERY REVIEWS

Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells

(2012) Kwang-Chul Kwon et al.   ADVANCED DRUG DELIVERY REVIEWS

Optimizing efficacy of mucosal vaccines

(2012) Ayman Gebril et al.   Expert Review of Vaccines

Oral immunogenicity of porcine reproductive and respiratory syndrome virus antigen expressed in transgenic banana

(2012) Hui-Ting Chan et al.   PLANT BIOTECHNOLOGY JOURNAL

A chloroplast-derivedToxoplasma gondiiGRA4 antigen used as an oral vaccine protects against toxoplasmosis in mice

(2012) María del L. Yácono et al.   PLANT BIOTECHNOLOGY JOURNAL

RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine

(2012) Yoshikazu Yuki et al.   VACCINE

Transgenic tobacco expressed HPV16-L1 and LT-B combined immunization induces strong mucosal and systemic immune responses in mice

(2012) Liu Hongli et al.   Human Vaccines & Immunotherapeutics

Glucose lowering effect of transgenic human insulin-like growth factor-I from rice: in vitro and in vivo studies

(2011) Stanley CK Cheung et al.   BMC BIOTECHNOLOGY

Construction of a Der p2-transgenic plant for the alleviation of airway inflammation

(2011) CC Lee et al.   Cellular & Molecular Immunology

Oral tolerance

(2011) Howard L. Weiner et al.   IMMUNOLOGICAL REVIEWS

Murine immune responses to a Plasmodium vivax-derived chimeric recombinant protein expressed in Brassica napus

(2011) Choonghee Lee et al.   MALARIA JOURNAL

Neutralizing antibodies against rotavirus produced in transgenically labelled purple tomatoes

(2011) Paloma Juárez et al.   PLANT BIOTECHNOLOGY JOURNAL

Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression

(2011) Kazuya Suzuki et al.   PLANT BIOTECHNOLOGY JOURNAL

Immunogenicity of chloroplast-derived HIV-1 p24 and a p24-Nef fusion protein following subcutaneous and oral administration in mice

(2011) Nuria Gonzalez-Rabade et al.   PLANT BIOTECHNOLOGY JOURNAL

Immunogenicity of nuclear-encoded LTB:ST fusion protein from Escherichia coli expressed in tobacco plants

(2011) Sergio Rosales-Mendoza et al.   PLANT CELL REPORTS

Bioprocessing of plant-derived virus-like particles of Norwalk virus capsid protein under current Good Manufacture Practice regulations

(2011) Huafang Lai et al.   PLANT CELL REPORTS

High Levels of Bioplastic Are Produced in Fertile Transplastomic Tobacco Plants Engineered with a Synthetic Operon for the Production of Polyhydroxybutyrate

(2011) K. Bohmert-Tatarev et al.   PLANT PHYSIOLOGY

Plant-made pharmaceuticals for the prevention and treatment of autoimmune diseases: where are we?

(2010) Linda Avesani et al.   Expert Review of Vaccines

Plant glycans: friend or foe in vaccine development?

(2010) Dirk Bosch et al.   Expert Review of Vaccines

Immunology of gut mucosal vaccines

(2010) Marcela F. Pasetti et al.   IMMUNOLOGICAL REVIEWS

Oral immunogenicity of tomato-derived sDPT polypeptide containing Corynebacterium diphtheriae, Bordetella pertussis and Clostridium tetani exotoxin epitopes

(2010) Ruth E. Soria-Guerra et al.   PLANT CELL REPORTS

Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice

(2010) D. Verma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenicity and virus-like particle formation of rotavirus capsid proteins produced in transgenic plants

(2010) YanMei Yang et al.   Science China-Life Sciences

Mucosal Immunity: Induction, Dissemination, and Effector Functions

(2009) P. Brandtzaeg   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Immunoadjuvant Activity of Crude Lectin Extracted from Momordica Charantia Seed

(2008) Li HUANG et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors

(2008) Eugenio Butelli et al.   NATURE BIOTECHNOLOGY