Nuclear FAK: a new mode of gene regulation from cellular adhesions

FERM control of FAK function: Implications for cancer therapy

(2014) Ssang-Taek Lim et al.   CELL CYCLE

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression

(2012) Ssang-Taek Lim et al.   JOURNAL OF CELL BIOLOGY

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

(2011) J. B. Stokes et al.   MOLECULAR CANCER THERAPEUTICS

Merlin/NF2 Functions Upstream of the Nuclear E3 Ubiquitin Ligase CRL4DCAF1 to Suppress Oncogenic Gene Expression

(2011) J. Cooper et al.   Science Signaling

XIAP is essential for shear stress-enhanced Tyr-576 phosphorylation of FAK

(2010) Sunyoung Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model

(2010) Cedo M Bagi et al.   CANCER BIOLOGY & THERAPY

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

(2010) Colin Walsh et al.   CANCER BIOLOGY & THERAPY

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

(2010) Ssang-Taek Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development

(2010) Xiaofeng Zhao et al.   JOURNAL OF CELL BIOLOGY

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

The FERM domain: organizing the structure and function of FAK

(2010) Margaret C. Frame et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2

(2009) Shi-Wen Luo et al.   EMBO JOURNAL

TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes

(2009) Michael Karin et al.   IMMUNOLOGICAL REVIEWS

Pyk2 Inhibition of p53 as an Adaptive and Intrinsic Mechanism Facilitating Cell Proliferation and Survival

(2009) Ssang-Taek Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4motif: evidence that nuclear paxillin promotes cell proliferation

(2008) Jing-Ming Dong et al.   BIOCHEMICAL JOURNAL

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

FAK nuclear export signal sequences

(2008) Valeria Ossovskaya et al.   FEBS LETTERS

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

(2008) Sara M. Weis et al.   JOURNAL OF CELL BIOLOGY

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

(2008) Yangmi Lim et al.   JOURNAL OF CELL BIOLOGY

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

(2008) Ssang-Taek Lim et al.   MOLECULAR CELL