Location, function, and ontogeny of pulmonary macrophages during the steady state

Genetic disorders of surfactant protein dysfunction: when to consider and how to investigate

(2016) Atul Gupta et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Macrophage precursors PLASTed INto alveolar space

(2016) M. Guilliams et al.   BLOOD

Alveolar macrophage development in mice requires L-plastin for cellular localization in alveoli

(2016) E. M. Todd et al.   BLOOD

Lung surfactant metabolism: early in life, early in disease and target in cell therapy

(2016) Elena Lopez-Rodriguez et al.   CELL AND TISSUE RESEARCH

Pulmonary Alveolar Proteinosis Syndrome

(2016) Takuji Suzuki et al.   CLINICS IN CHEST MEDICINE

Unperturbed vs. post-transplantation hematopoiesis

(2016) Katrin Busch et al.   CURRENT OPINION IN HEMATOLOGY

CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin

(2016) Linda Männ et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

IL-10-producing lung interstitial macrophages prevent neutrophilic asthma

(2016) Hideo Kawano et al.   INTERNATIONAL IMMUNOLOGY

Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells

(2016) Xiaodi Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alveolar Epithelial Cell–Derived Prostaglandin E2Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation

(2016) Jennifer M. Speth et al.   JOURNAL OF IMMUNOLOGY

PGE2 -treated macrophages inhibit development of allergic lung inflammation in mice

(2016) Christina Draijer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of an atypical monocyte and committed progenitor involved in fibrosis

(2016) Takashi Satoh et al.   NATURE

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

The development and maintenance of resident macrophages

(2016) Elisa Gomez Perdiguero et al.   NATURE IMMUNOLOGY

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

Macrophage-epithelial interactions in pulmonary alveoli

(2016) Jahar Bhattacharya et al.   Seminars in Immunopathology

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

(2016) Calum C. Bain et al.   Nature Communications

Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma

(2016) Franziska Hoffmann et al.   Frontiers in Immunology

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

(2015) Franziska Paul et al.   CELL

The Origin of Tissue-Resident Macrophages: When an Erythro-myeloid Progenitor Is an Erythro-myeloid Progenitor

(2015) Elisa Gomez Perdiguero et al.   IMMUNITY

Fetal HSCs versus EMP2s

(2015) Jianpeng Sheng et al.   IMMUNITY

Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells

(2015) Jianpeng Sheng et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

(2015) Emilie Bourdonnay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

(2015) Katrin Busch et al.   NATURE

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Functional classification of memory CD8+ T cells by CX3CR1 expression

(2015) Jan P. Böttcher et al.   Nature Communications

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Progressive replacement of embryo-derived cardiac macrophages with age

(2014) Kaaweh Molawi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resident Alveolar Macrophages Suppress, whereas Recruited Monocytes Promote, Allergic Lung Inflammation in Murine Models of Asthma

(2014) Zbigniew Zasłona et al.   JOURNAL OF IMMUNOLOGY

Pulmonary macrophage transplantation therapy

(2014) Takuji Suzuki et al.   NATURE

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

(2014) Kristin Westphalen et al.   NATURE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection

(2014) Christoph Schneider et al.   PLoS Pathogens

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Lung-resident tissue macrophages generate Foxp3+regulatory T cells and promote airway tolerance

(2013) Pejman Soroosh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Depletion of Alveolar Macrophages during Influenza Infection Facilitates Bacterial Superinfections

(2013) H. E. Ghoneim et al.   JOURNAL OF IMMUNOLOGY

Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections

(2013) M Guilliams et al.   Mucosal Immunology

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

The Transcription Factor IRF3 Triggers “Defensive Suicide” Necrosis in Response to Viral and Bacterial Pathogens

(2013) Nelson C. Di Paolo et al.   Cell Reports

Pulmonary Macrophage Subpopulations in the Induction and Resolution of Acute Lung Injury

(2012) Laura K. Johnston et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lung Dendritic Cells in Respiratory Viral Infection and Asthma: From Protection to Immunopathology

(2012) Bart N. Lambrecht et al.   Annual Review of Immunology

Regulation of lung surfactant phospholipid synthesis and metabolism

(2012) Victoria Goss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulation of microglia development and homeostasis

(2012) Melanie Greter et al.   GLIA

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Type 2 Innate Immunity in Helminth Infection Is Induced Redundantly and Acts Autonomously following CD11c+Cell Depletion

(2012) Katherine A. Smith et al.   INFECTION AND IMMUNITY

Alveolar epithelial cells orchestrate DC function in murine viral pneumonia

(2012) Barbara Unkel et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

(2012) Monique A.M. Willart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systemic Analysis of PPAR  in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway Immunity

(2012) E. L. Gautier et al.   JOURNAL OF IMMUNOLOGY

TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells

(2012) L A Albacker et al.   Mucosal Immunology

Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice

(2012) André P Tittel et al.   NATURE METHODS

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Surfactant and its role in the pathobiology of pulmonary infection

(2011) Jennifer R. Glasser et al.   MICROBES AND INFECTION

Targeted PPARγ deficiency in alveolar macrophages disrupts surfactant catabolism

(2010) Anna D. Baker et al.   JOURNAL OF LIPID RESEARCH

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice

(2009) Denis Bedoret et al.   JOURNAL OF CLINICAL INVESTIGATION

Deletion of PPAR  in Alveolar Macrophages Is Associated with a Th-1 Pulmonary Inflammatory Response

(2009) A. Malur et al.   JOURNAL OF IMMUNOLOGY

Essential Roles for Dok2 and RasGAP in CD200 Receptor-Mediated Regulation of Human Myeloid Cells

(2009) R. Mihrshahi et al.   JOURNAL OF IMMUNOLOGY

A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells

(2008) Kristin Hochweller et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Origins and tissue-context-dependent fates of blood monocytes

(2008) Chen Varol et al.   IMMUNOLOGY AND CELL BIOLOGY

Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation

(2008) Angela Haczku   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

(2008) Robert J Snelgrove et al.   NATURE IMMUNOLOGY