Gut microbiota in non‐alcoholic fatty liver disease and alcohol‐related liver disease: Current concepts and perspectives

Alcohol, liver disease and the gut microbiota

(2019) Jasmohan S. Bajaj   Nature Reviews Gastroenterology & Hepatology

Effects of ursodeoxycholic acid on the gut microbiome and colorectal adenoma development

(2019) Talima Pearson et al.   Cancer Medicine

Can oral bacteria affect the microbiome of the gut?

(2019) Ingar Olsen et al.   Journal of Oral Microbiology

A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease

(2019) Cyrielle Caussy et al.   Nature Communications

Microbiome as a therapeutic target in alcohol-related liver disease

(2019) Shiv K. Sarin et al.   JOURNAL OF HEPATOLOGY

Gut microbiota in liver disease: Too much is harmful, nothing at all is not helpful either

(2019) Phillipp Hartmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile Acids as Metabolic Regulators and Nutrient Sensors

(2019) John Y. L. Chiang et al.   Annual Review of Nutrition

Review article: emerging role of the gut microbiome in the progression of nonalcoholic fatty liver disease and potential therapeutic implications

(2019) Saumya Jayakumar et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

FxR-modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis

(2019) M. Sorribas et al.   JOURNAL OF HEPATOLOGY

Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease

(2019) Rohit Loomba et al.   Cell Metabolism

Microbiota and nonalcoholic fatty liver disease

(2019) Christelle Knudsen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease

(2019) Karn Wijarnpreecha et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

(2019) Jing Yuan et al.   Cell Metabolism

The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease

(2019) Huikuan Chu et al.   JOURNAL OF HEPATOLOGY

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

(2019) Yi Duan et al.   NATURE

Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant

(2019) Zachariah DeFilipp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diversification of host bile acids by members of the gut microbiota

(2019) Jenessa A. Winston et al.   Gut Microbes

The gut microbiota: A new target in the management of alcohol dependence?

(2018) Sophie Leclercq et al.   ALCOHOL

Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis

(2018) B. Hameed et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol

(2018) Parkyong Song et al.   Cell Metabolism

Bile Acid Metabolism in Liver Pathobiology

(2018) John Y. L. Chiang et al.   GENE EXPRESSION

Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis

(2018) Zobair M. Younossi et al.   HEPATOLOGY

Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

(2018) Phillipp Hartmann et al.   HEPATOLOGY

Microbiome and Bile Acid Profiles in Duodenal Aspirates from Cirrhotics: The Microbiome, Microbial Markers and Liver Disease Study

(2018) Jonathan P. Jacobs et al.   HEPATOLOGY RESEARCH

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis

(2018) Katharina Brandl et al.   JOURNAL OF HEPATOLOGY

Diagnosis of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Why liver biopsy is essential

(2018) Pierre Bedossa   LIVER INTERNATIONAL

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Triggering and resolution of inflammation in NASH

(2018) Susanne Schuster et al.   Nature Reviews Gastroenterology & Hepatology

The gut–liver axis and the intersection with the microbiome

(2018) Anupriya Tripathi et al.   Nature Reviews Gastroenterology & Hepatology

Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice

(2018) Shoji Yamada et al.   Oncotarget

Dysbiosis and Ecotypes of the Salivary Microbiome Associated With Inflammatory Bowel Diseases and the Assistance in Diagnosis of Diseases Using Oral Bacterial Profiles

(2018) Zhe Xun et al.   Frontiers in Microbiology

Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis

(2018) Dragos Ciocan et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Animal models of cholestasis: An update on inflammatory cholangiopathies

(2018) Valeria Mariotti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Emerging Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease: From Composition to Function

(2018) S.R. Sharpton et al.   Clinical Gastroenterology and Hepatology

Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease

(2018) Huikuan Chu et al.   GUT

Microbiota stability in healthy individuals after single-dose lactulose challenge—A randomized controlled study

(2018) Sandra Y. Wotzka et al.   PLoS One

Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction

(2018) Da Jung Kim et al.   Scientific Reports

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

(2018) Ruiting Han et al.   Frontiers of Medicine

Gut Microbiota and Complications of Liver Disease

(2017) Chathur Acharya et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy

(2017) Ruqi Tang et al.   GUT

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Gut–liver axis, cirrhosis and portal hypertension: the chicken and the egg

(2017) Juan P. Arab et al.   Hepatology International

Intestinal fungi contribute to development of alcoholic liver disease

(2017) An-Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice

(2017) Gladys Ferrere et al.   JOURNAL OF HEPATOLOGY

Gut microbiome and liver disease

(2017) Naga S. Betrapally et al.   Translational Research

Genetic Loss of Immunoglobulin A Does Not Influence Development of Alcoholic Steatohepatitis in Mice

(2016) Tatsuo Inamine et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

(2016) Christopher Staley et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

(2016) Lirui Wang et al.   Cell Host & Microbe

Nonalcoholic Fatty Liver Disease and the Gut Microbiome

(2016) Jerome Boursier et al.   Clinics in Liver Disease

Innate Immunity and Inflammation in NAFLD/NASH

(2016) Marco Arrese et al.   DIGESTIVE DISEASES AND SCIENCES

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls

(2016) Martin Kummen et al.   GUT

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

(2016) Juan P. Arab et al.   HEPATOLOGY

Rifaximin has no effect on hemodynamics in decompensated cirrhosis: A randomized, double-blind, placebo-controlled trial

(2016) Nina Kimer et al.   HEPATOLOGY

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules

(2016) Bryan L. Copple et al.   PHARMACOLOGICAL RESEARCH

Primary Biliary Cirrhosis and the Microbiome

(2016) Eamonn Quigley   SEMINARS IN LIVER DISEASE

Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease

(2016) Marialena Mouzaki et al.   PLoS One

Alcoholic Liver Disease: The Gut Microbiome and Liver Cross Talk

(2015) Phillipp Hartmann et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Microbiota Protects Mice Against Acute Alcohol-Induced Liver Injury

(2015) Peng Chen et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Review article: alcohol and gut microbiota - the possible role of gut microbiota modulation in the treatment of alcoholic liver disease

(2015) G. Vassallo et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Systematic review: microbial dysbiosis and nonalcoholic fatty liver disease

(2015) A. Wieland et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Excessive bile acid activated NF-kappa B and promoted the development of alcoholic steatohepatitis in farnesoid X receptor deficient mice

(2015) Wei-Bin Wu et al.   BIOCHIMIE

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

The intestinal microbiota: its role in health and disease

(2015) Luc Biedermann et al.   EUROPEAN JOURNAL OF PEDIATRICS

Gut–Liver Axis in Alcoholic Liver Disease

(2015) Gyongyi Szabo   GASTROENTEROLOGY

Proton pump inhibitors alter the composition of the gut microbiota

(2015) Matthew A Jackson et al.   GUT

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

(2015) James H. Tabibian et al.   HEPATOLOGY

Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice

(2015) Peng Chen et al.   HEPATOLOGY

Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy

(2015) Jasmohan S. Bajaj et al.   HEPATOLOGY

The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation

(2015) Niels van Best et al.   Hepatology International

Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis

(2015) Mauro Bernardi et al.   JOURNAL OF HEPATOLOGY

Agonist of farnesoid X receptor protects against bile acid induced damage and oxidative stress in mouse placenta – A study on maternal cholestasis model

(2015) W.-B. Wu et al.   PLACENTA

The Gut Microbiota and Nonalcoholic Fatty Liver Disease

(2015) Howard Monsour et al.   SEMINARS IN LIVER DISEASE

TGR5 and Immunometabolism: Insights from Physiology and Pharmacology

(2015) Alessia Perino et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Host-Microbiome Interactions in Alcoholic Liver Disease

(2014) Peng Chen et al.   Gut and Liver

Immune tolerance in liver disease

(2014) Ian N. Crispe   HEPATOLOGY

Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013

(2014) Rajiv Jalan et al.   JOURNAL OF HEPATOLOGY

Intestinal transport and metabolism of bile acids

(2014) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Effects of alcohol on intestinal epithelial barrier permeability and expression of tight junction-associated proteins

(2014) YING WANG et al.   Molecular Medicine Reports

Interleukin-6 Modulation of Intestinal Epithelial Tight Junction Permeability Is Mediated by JNK Pathway Activation of Claudin-2 Gene

(2014) Rana Al-Sadi et al.   PLoS One

Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity

(2014) Sophie Leclercq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

(2013) Anatoliy I. Masyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine

(2013) Bianca M. Arendt et al.   Applied Physiology Nutrition and Metabolism

Intrahepatic cholestasis in common chronic liver diseases

(2013) Christoph Jüngst et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption

(2013) Guoxiang Xie et al.   FASEB JOURNAL

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice

(2013) Phillipp Hartmann et al.   HEPATOLOGY

Altered profile of human gut microbiome is associated with cirrhosis and its complications

(2013) Jasmohan S. Bajaj et al.   JOURNAL OF HEPATOLOGY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment

(2013) Lara Bull-Otterson et al.   PLoS One

Modulation of the Metabiome by Rifaximin in Patients with Cirrhosis and Minimal Hepatic Encephalopathy

(2013) Jasmohan S. Bajaj et al.   PLoS One

Acetaldehyde disrupts tight junctions in Caco-2 cell monolayers by a protein phosphatase 2A-dependent mechanism

(2012) Mitzi Dunagan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation

(2012) Jasmohan S. Bajaj et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Colonic microbiome is altered in alcoholism

(2012) Ece A. Mutlu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy

(2012) Jasmohan S. Bajaj et al.   METABOLIC BRAIN DISEASE

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Effect of pre- and probiotics on liver regeneration after resection: a randomised, double-blind pilot study

(2012) N. Rayes et al.   Beneficial Microbes

The Unfolding Web of Innate Immune Dysregulation in Alcoholic Liver Injury

(2011) G. Szabo et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Linkage of gut microbiome with cognition in hepatic encephalopathy

(2011) Jasmohan S. Bajaj et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Characterization of fecal microbial communities in patients with liver cirrhosis

(2011) Yanfei Chen et al.   HEPATOLOGY

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut

(2011) Ekihiro Seki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Epithelial Barriers in Homeostasis and Disease

(2010) Amanda M. Marchiando et al.   Annual Review of Pathology-Mechanisms of Disease

Enteric dysbiosis associated with a mouse model of alcoholic liver disease

(2010) Arthur W. Yan et al.   HEPATOLOGY

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

(2010) Thijs W.H. Pols et al.   JOURNAL OF HEPATOLOGY

Intraperitoneal LPS amplifies portal hypertension in rat liver fibrosis

(2010) Christian J Steib et al.   LABORATORY INVESTIGATION

Acetaldehyde Adducts in Alcoholic Liver Disease

(2010) Mashiko Setshedi et al.   Oxidative Medicine and Cellular Longevity

Toll-like Receptor 4 and Hepatic Fibrogenesis

(2010) Jean-Philippe Pradere et al.   SEMINARS IN LIVER DISEASE

Toll-Like Receptors in the Pathogenesis of Alcoholic Liver Disease

(2010) Jan Petrasek et al.   Gastroenterology Research and Practice

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens

(2009) J G Fox et al.   GUT

MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses

(2009) Brett Verstak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB signalling: Embracing complexity to achieve translation

(2009) Jayashree Bagchi Chakraborty et al.   JOURNAL OF HEPATOLOGY

The Opposite Effects of Acute and Chronic Alcohol on Lipopolysaccharide-Induced Inflammation Are Linked to IRAK-M in Human Monocytes

(2009) P. Mandrekar et al.   JOURNAL OF IMMUNOLOGY

Oxidative Stress and Alcoholic Liver Disease

(2009) Defeng Wu et al.   SEMINARS IN LIVER DISEASE

Effect of Alcohol on miR-212 Expression in Intestinal Epithelial Cells and Its Potential Role in Alcoholic Liver Disease

(2008) Yueming Tang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY