Review article: emerging role of the gut microbiome in the progression of nonalcoholic fatty liver disease and potential therapeutic implications

Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study

(2018) Sofie Ingdam Halkjær et al.   GUT

Targeting FXR and FGF19 to Treat Metabolic Diseases—Lessons Learned From Bariatric Surgery

(2018) Nadejda Bozadjieva et al.   DIABETES

Rifaximin in non-alcoholic steatohepatitis: An open-label pilot study

(2017) Jeremy F.L. Cobbold et al.   HEPATOLOGY RESEARCH

Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial

(2017) Sudarshan Paramsothy et al.   LANCET

Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism

(2017) Simon Nicolas et al.   Molecular Systems Biology

Human Gut Microbiota: Toward an Ecology of Disease

(2017) Susannah Selber-Hnatiw et al.   Frontiers in Microbiology

Outcomes and prognostic factors of fecal microbiota transplantation in patients with slow transit constipation: results from a prospective study with long-term follow-up

(2017) Chao Ding et al.   Gastroenterology Report

Characterisation of the gastrointestinal mucosa-associated microbiota: a novel technique to prevent cross-contamination during endoscopic procedures

(2016) E. R. Shanahan et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

(2016) Samir Softic et al.   DIGESTIVE DISEASES AND SCIENCES

Function of Autophagy in Nonalcoholic Fatty Liver Disease

(2016) Mark J. Czaja   DIGESTIVE DISEASES AND SCIENCES

Natural History of Nonalcoholic Fatty Liver Disease

(2016) George Boon-Bee Goh et al.   DIGESTIVE DISEASES AND SCIENCES

Gut microbiome and liver diseases

(2016) Herbert Tilg et al.   GUT

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohnʼs Disease

(2016) Byron P. Vaughn et al.   INFLAMMATORY BOWEL DISEASES

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

(2016) Mingming Sun et al.   JOURNAL OF GASTROENTEROLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

NAFLD and liver transplantation: Current burden and expected challenges

(2016) Raluca Pais et al.   JOURNAL OF HEPATOLOGY

The role of Gut Microbiota in the development of obesity and Diabetes

(2016) Othman A. Baothman et al.   Lipids in Health and Disease

Comparative efficacy of interventions on nonalcoholic fatty liver disease (NAFLD)

(2016) Ratree Sawangjit et al.   MEDICINE

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting Dysbiosis for the Treatment of Liver Disease

(2016) Gobind Anand et al.   SEMINARS IN LIVER DISEASE

Use of rifaximin in gastrointestinal and liver diseases

(2016) Rani H Shayto et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Causality of small and large intestinal microbiota in weight regulation and insulin resistance

(2016) Torsten P.M. Scheithauer et al.   Molecular Metabolism

Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease

(2016) Marialena Mouzaki et al.   PLoS One

Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults

(2016) Yu-ming Chen et al.   Scientific Reports

Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies

(2015) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Circulating leptin in non-alcoholic fatty liver disease: a systematic review and meta-analysis

(2015) Stergios A. Polyzos et al.   DIABETOLOGIA

Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease

(2015) Venkatanarayana Gangarapu et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Systematic review on intervention with prebiotics/probiotics in patients with obesity-related nonalcoholic fatty liver disease

(2015) Giovanni Tarantino et al.   Future Microbiology

Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial

(2015) Paul Moayyedi et al.   GASTROENTEROLOGY

Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: A systematic review and network meta-analysis

(2015) Siddharth Singh et al.   HEPATOLOGY

Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells

(2015) Ikkou Kashiwagi et al.   IMMUNITY

Urinary 1H-NMR-based metabolic profiling of children with NAFLD undergoing VSL#3 treatment

(2015) A Miccheli et al.   INTERNATIONAL JOURNAL OF OBESITY

Donor Species Richness Determines Faecal Microbiota Transplantation Success in Inflammatory Bowel Disease

(2015) Severine Vermeire et al.   Journal of Crohns & Colitis

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Obesity and the gastrointestinal microbiota: a review of associations and mechanisms

(2015) C. Graham et al.   NUTRITION REVIEWS

Fecal microbiota transplantation broadening its application beyond intestinal disorders

(2015) Meng-Que Xu   WORLD JOURNAL OF GASTROENTEROLOGY

Role of the normal gut microbiota

(2015) Sai Manasa Jandhyala   WORLD JOURNAL OF GASTROENTEROLOGY

Association Between Patatin-Like Phospholipase Domain Containing 3 Gene (PNPLA3) Polymorphisms and Nonalcoholic Fatty Liver Disease: A HuGE Review and Meta-Analysis

(2015) Renfan Xu et al.   Scientific Reports

Fecal microbiota transplantation and bacterial consortium transplantation have comparable effects on the re-establishment of mucosal barrier function in mice with intestinal dysbiosis

(2015) Ming Li et al.   Frontiers in Microbiology

Weight Gain After Fecal Microbiota Transplantation

(2015) N. Alang et al.   Open Forum Infectious Diseases

Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis

(2014) A. Alisi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans

(2014) S Rahat-Rozenbloom et al.   INTERNATIONAL JOURNAL OF OBESITY

Oral, Capsulized, Frozen Fecal Microbiota Transplantation for RelapsingClostridium difficileInfection

(2014) Ilan Youngster et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of probiotic yogurt consumption on metabolic factors in individuals with nonalcoholic fatty liver disease

(2014) S. Nabavi et al.   JOURNAL OF DAIRY SCIENCE

Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?

(2014) Georgina L Hold   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

(2014) Lin Jia et al.   Nature Communications

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

(2014) J Fernandes et al.   Nutrition & Diabetes

Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells

(2014) Mariagrazia Valentini et al.   Journal of Immunology Research

The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases

(2014) Caroline Marcantonio Ferreira et al.   Journal of Immunology Research

Prevalence of Nonalcoholic Fatty Liver Disease in the United States: The Third National Health and Nutrition Examination Survey, 1988–1994

(2013) Mariana Lazo et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals

(2013) Howard C. Masuoka et al.   Annals of the New York Academy of Sciences

Diabetes, obesity and gut microbiota

(2013) Amandine Everard et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Gut microbiota and non-alcoholic fatty liver disease: new insights

(2013) J. Aron-Wisnewsky et al.   CLINICAL MICROBIOLOGY AND INFECTION

Intestinal microbiota in patients with nonalcoholic fatty liver disease

(2013) Marialena Mouzaki et al.   HEPATOLOGY

Impact of Ethnicity, Geography, and Disease on the Microbiota in Health and Inflammatory Bowel Disease

(2013) Lani Prideaux et al.   INFLAMMATORY BOWEL DISEASES

Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)

(2013) Akinobu Takaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of the intestinal microbiome in liver disease

(2013) Jorge Henao-Mejia et al.   JOURNAL OF AUTOIMMUNITY

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

(2013) Genta Kakiyama et al.   JOURNAL OF HEPATOLOGY

Fecal Transplantation for RecurrentClostridium difficileInfection in Older Adults: A Review

(2013) Kristin E. Burke et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Toll-like receptors and liver disease

(2013) Vivek Kesar et al.   LIVER INTERNATIONAL

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Modulation of the Metabiome by Rifaximin in Patients with Cirrhosis and Minimal Hepatic Encephalopathy

(2013) Jasmohan S. Bajaj et al.   PLoS One

Rifaximin-Mediated Changes to the Epithelial Cell Proteome: 2-D Gel Analysis

(2013) Caroline Schrodt et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis

(2013) Yan-Yan Ma   WORLD JOURNAL OF GASTROENTEROLOGY

Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling

(2012) Kento Imajo et al.   Cell Metabolism

Nutrition, Intestinal Permeability, and Blood Ethanol Levels Are Altered in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

(2012) Valentina Volynets et al.   DIGESTIVE DISEASES AND SCIENCES

The composition and metabolic activity of child gut microbiota demonstrate differential adaptation to varied nutrient loads in an in vitro model of colonic fermentation

(2012) Amanda N. Payne et al.   FEMS MICROBIOLOGY ECOLOGY

Selective Ablation of Peptide YY Cells in Adult Mice Reveals Their Role in Beta Cell Survival

(2012) Amir H. Sam et al.   GASTROENTEROLOGY

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice

(2012) Dewei Ye et al.   GUT

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

(2012) Tiphaine Le Roy et al.   GUT

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Circulating Zonulin, a Marker of Intestinal Permeability, Is Increased in Association with Obesity-Associated Insulin Resistance

(2012) José María Moreno-Navarrete et al.   PLoS One

A metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response

(2012) Scott Schwartz et al.   GENOME BIOLOGY

Fecal microbiota transplantation in relapsing Clostridium difficile infection

(2012) Faith Rohlke et al.   Therapeutic Advances in Gastroenterology

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis

(2011) Michele Malaguarnera et al.   DIGESTIVE DISEASES AND SCIENCES

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism

(2011) Fang Yan et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut Microbiota, Intestinal Permeability, Obesity-Induced Inflammation, and Liver Injury

(2011) Thomas H. Frazier et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Effects of Lactobacillus rhamnosus Strain GG in Pediatric Obesity-related Liver Disease

(2011) Pietro Vajro et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

The potential role of prebiotic fibre for treatment and management of non-alcoholic fatty liver disease and associated obesity and insulin resistance

(2011) Jill A. Parnell et al.   LIVER INTERNATIONAL

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications

(2011) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Obesity, Diabetes, and Gut Microbiota: The hygiene hypothesis expanded?

(2010) G. Musso et al.   DIABETES CARE

Innate Immunity and Steatohepatitis: A Critical Role of Another Toll (TLR-9)

(2010) Bin Gao   GASTROENTEROLOGY

Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency

(2010) Melanie D. Spencer et al.   GASTROENTEROLOGY

Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

(2010) E F Murphy et al.   GUT

Rifaximin-induced alteration of virulence of diarrhoea-producing Escherichia coli and Shigella sonnei

(2010) Zhi-Dong Jiang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Decreased Fat Storage by Lactobacillus Paracasei Is Associated with Increased Levels of Angiopoietin-Like 4 Protein (ANGPTL4)

(2010) Linda Aronsson et al.   PLoS One

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

(2010) M. J. Claesson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

(2010) B. D. Wallace et al.   SCIENCE

Small-intestinal bacterial overgrowth in cirrhosis is related to the severity of liver disease

(2009) C. PANDE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pretreatment of Epithelial Cells with Rifaximin Alters Bacterial Attachment and Internalization Profiles

(2009) E. L. Brown et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

Role of Insulin Resistance and Lipotoxicity in Non-Alcoholic Steatohepatitis

(2009) Kenneth Cusi   Clinics in Liver Disease

Association Between Small Intestinal Bacterial Overgrowth and Peripheral Bacterial DNA in Cirrhotic Patients

(2009) Dae Won Jun et al.   DIGESTIVE DISEASES AND SCIENCES

Conversion of cholic acid and chenodeoxycholic acid into their 7-oxo derivatives byBacteroides intestinalisAM-1 isolated from human feces

(2009) Satoru Fukiya et al.   FEMS MICROBIOLOGY LETTERS

The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors

(2009) Salvatore Modica et al.   GASTROENTEROLOGY

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

The gut microbiota modulates host energy and lipid metabolism in mice

(2009) Vidya R. Velagapudi et al.   JOURNAL OF LIPID RESEARCH

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

(2009) Sabrina Cipriani et al.   JOURNAL OF LIPID RESEARCH

Interactions of gut microbiota with functional food components and nutraceuticals

(2009) J.M. Laparra et al.   PHARMACOLOGICAL RESEARCH

Human gut microbiota in obesity and after gastric bypass

(2009) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

(2009) T. A. Clayton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine

Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation

(2008) Francesco Raimondi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY