Toll-Like Receptors 2, -3 and -4 Prime Microglia but not Astrocytes Across Central Nervous System Regions for ATP-Dependent Interleukin-1β Release

Protection of ischemic post conditioning against transient focal ischemia-induced brain damage is associated with inhibition of neuroinflammation via modulation of TLR2 and TLR4 pathways

(2014) Ying Wang et al.   Journal of Neuroinflammation

Role of the TLR4 pathway in blood-spinal cord barrier dysfunction during the bimodal stage after ischemia/reperfusion injury in rats

(2014) Xiao-Qian Li et al.   Journal of Neuroinflammation

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Astrocyte-Microglia Cooperation in the Expression of a Pro-Inflammatory Phenotype

(2013) Massimo Barbierato et al.   CNS & Neurological Disorders-Drug Targets

The adapter proteins of TLRs, TRIF and MYD88, are upregulated in depressed individuals

(2013) Batool Hajebrahimi et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE

Neuroinflammation and psychiatric illness

(2013) Souhel Najjar et al.   Journal of Neuroinflammation

Activation of microglia induces symptoms of Parkinson’s disease in wild-type, but not in IL-1 knockout mice

(2013) Sachiko Tanaka et al.   Journal of Neuroinflammation

Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia

(2013) Linli Yao et al.   Journal of Neuroinflammation

Toll-Like Receptor-3 Activation Increases the Vulnerability of the Neonatal Brain to Hypoxia-Ischemia

(2013) L. Stridh et al.   JOURNAL OF NEUROSCIENCE

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Assessing Activation States in Microglia

(2012) Carol A. Colton et al.   CNS & Neurological Disorders-Drug Targets

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury

(2012) Michael J. Chen et al.   GLIA

Microglia are required for astroglial toll-like receptor 4 response and for optimal TLR2 and TLR3 response

(2012) Thomas H. Holm et al.   GLIA

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Neonatal rat microglia derived from different brain regions have distinct activation responses

(2012) Aaron Y. Lai et al.   Neuron Glia Biology

Resident glial cell activation in response to perispinal inflammation leads to acute changes in nociceptive sensitivity: Implications for the generation of neuropathic pain

(2012) Gustavo Tenorio et al.   PAIN

Inflammation and neurodegeneration: the story ‘retolled’

(2012) Janelle Drouin-Ouellet et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Toll-like receptors in chronic pain

(2011) Lauren Nicotra et al.   EXPERIMENTAL NEUROLOGY

Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2

(2011) Alexandra Kadl et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

(2011) Dan Zhang et al.   Journal of Neuroinflammation

Stroke research at a crossroad: asking the brain for directions

(2011) Costantino Iadecola et al.   NATURE NEUROSCIENCE

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

A new definition of neuropathic pain

(2011) Troels S. Jensen et al.   PAIN

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

P2X7-Dependent Release of Interleukin-1  and Nociception in the Spinal Cord following Lipopolysaccharide

(2010) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Chronic stress induces transient spinal neuroinflammation, triggering sensory hypersensitivity and long-lasting anxiety-induced hyperalgesia

(2010) Cyril Rivat et al.   PAIN

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IMMUNOLOGY: Dangers In and Out

(2009) M. E. Bianchi et al.   SCIENCE

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

THIS ARTICLE HAS BEEN RETRACTED: Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury

(2008) Koichi Obata et al.   JOURNAL OF NEUROCHEMISTRY

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

(2008) Jing-Ji Jin et al.   Journal of Neuroinflammation