REDD1 deficiency protects against nonalcoholic hepatic steatosis induced by high‐fat diet

Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease

(2018) Juan Pablo Arab et al.   Annual Review of Pathology-Mechanisms of Disease

Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress

(2018) Florian A. Britto et al.   BMC BIOLOGY

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

(2018) Tatsuya Yamada et al.   Cell Metabolism

Induction of REDD1 via AP-1 prevents oxidative stress-mediated injury in hepatocytes

(2018) Sam Seok Cho et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Animal models of obesity and diabetes mellitus

(2018) Maximilian Kleinert et al.   Nature Reviews Endocrinology

Triggering and resolution of inflammation in NASH

(2018) Susanne Schuster et al.   Nature Reviews Gastroenterology & Hepatology

mTORC1 as the main gateway to autophagy

(2017) Yoana Rabanal-Ruiz et al.   Essays in Biochemistry

CD44 is a key player in non-alcoholic steatohepatitis

(2017) Stéphanie Patouraux et al.   JOURNAL OF HEPATOLOGY

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

(2017) Oscar Alvarez-Garcia et al.   Arthritis & Rheumatology

Implication of REDD1 in the activation of inflammatory pathways

(2017) Faustine Pastor et al.   Scientific Reports

Emerging role for regulated in development and DNA damage 1 (REDD1) in the regulation of skeletal muscle metabolism

(2016) Bradley S. Gordon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Is REDD1 a Metabolic Éminence Grise ?

(2016) Christopher Lipina et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Aberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabetics

(2015) David L. Williamson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

(2015) Shuxi Qiao et al.   Nature Communications

Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of Akt

(2015) Heidi L. Kenerson et al.   PLoS One

Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling

(2014) Cory M. Dungan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition

(2014) Atsushi Umemura et al.   Cell Metabolism

Cathepsin S inhibition lowers blood glucose levels in mice

(2014) Jean-Charles Lafarge et al.   DIABETOLOGIA

Alcoholic and non-alcoholic steatohepatitis

(2014) Manuela G. Neuman et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Role of Mitochondria in Nonalcoholic Fatty Liver Disease

(2014) Fatiha Nassir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency

(2014) David L. Williamson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Regulated in Development and DNA Damage 1 Is Necessary for Hyperglycemia-induced Vascular Endothelial Growth Factor Expression in the Retina of Diabetic Rodents

(2014) Michael D. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

(2014) M. Cornu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling

(2014) M. D. Dennis et al.   Science Signaling

Osteopontin deficiency aggravates hepatic injury induced by ischemia–reperfusion in mice

(2014) S Patouraux et al.   Cell Death & Disease

Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues

(2013) Michael Schupp et al.   BMC GENOMICS

Salidroside protects against hydrogen peroxide-induced injury in HUVECs via the regulation of REDD1 and mTOR activation

(2013) MAO-CHUN XU et al.   Molecular Medicine Reports

Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK, eIF2α phosphorylation, ATF4-dependent cascade

(2012) Scot R. Kimball et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

(2012) A. Bertola et al.   DIABETES

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

(2012) Fadila Benhamed et al.   JOURNAL OF CLINICAL INVESTIGATION

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The Osteopontin Level in Liver, Adipose Tissue and Serum Is Correlated with Fibrosis in Patients with Alcoholic Liver Disease

(2012) Stéphanie Patouraux et al.   PLoS One

Regulated in Development and DNA Damage Responses -1 (REDD1) Protein Contributes to Insulin Signaling Pathway in Adipocytes

(2012) Claire Regazzetti et al.   PLoS One

Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy

(2011) Juha J. Hulmi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Ablation of PI3K p110-  Prevents High-Fat Diet-Induced Liver Steatosis

(2011) M. Chattopadhyay et al.   DIABETES

Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia

(2011) N. C. Wolff et al.   MOLECULAR AND CELLULAR BIOLOGY

Feedback Control of p53 Translation by REDD1 and mTORC1 Limits the p53-Dependent DNA Damage Response

(2011) D. D. Vadysirisack et al.   MOLECULAR AND CELLULAR BIOLOGY

Tuberous Sclerosis Complex-1 Deficiency Attenuates Diet-Induced Hepatic Lipid Accumulation

(2011) Heidi L. Kenerson et al.   PLoS One

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

(2010) Toshinori Yoshida et al.   NATURE MEDICINE

Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

(2010) P. Horak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

(2009) Karla F. Leavens et al.   Cell Metabolism

Activating transcription factor 4 and CCAAT/enhancer-binding protein-β negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress

(2009) Hyeon-Ok Jin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Insulin Induces REDD1 Expression through Hypoxia-inducible Factor 1 Activation in Adipocytes

(2009) Claire Regazzetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Hepatic Gene Expression in Morbidly Obese Women: Implications for Disease Susceptibility

(2009) Marshall B. Elam et al.   Obesity

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

(2008) Michael L. Whitney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism

(2008) Su Mi Choi et al.   NUCLEIC ACIDS RESEARCH