Cathepsin S inhibition lowers blood glucose levels in mice

Pathogenesis of Prediabetes: Role of the Liver in Isolated Fasting Hyperglycemia and Combined Fasting and Postprandial Hyperglycemia

(2013) Rita Basu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cathepsin K Knockout Mitigates High-Fat Diet-Induced Cardiac Hypertrophy and Contractile Dysfunction

(2012) Y. Hua et al.   DIABETES

Serum Cathepsin S Is Associated With Decreased Insulin Sensitivity and the Development of Type 2 Diabetes in a Community-Based Cohort of Elderly Men

(2012) E. Jobs et al.   DIABETES CARE

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Control of Blood Glucose in the Absence of Hepatic Glucose Production During Prolonged Fasting in Mice: Induction of Renal and Intestinal Gluconeogenesis by Glucagon

(2011) E. Mutel et al.   DIABETES

Cathepsin S inhibitors: 2004 – 2010

(2011) Alice Lee-Dutra et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Association Between Serum Cathepsin S and Mortality in Older Adults

(2011) Elisabeth Jobs et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity

(2011) Mark Baugh et al.   JOURNAL OF AUTOIMMUNITY

Genetic and Pharmacological Evaluation of Cathepsin S in a Mouse Model of Asthma

(2010) Kathleen Deschamps et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pharmacological Inhibition of Cathepsin S Decreases Atherosclerotic Lesions in Apoe-/- Mice

(2010) Andriy O Samokhin et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cathepsins in Human Obesity: Changes in Energy Balance Predominantly Affect Cathepsin S in Adipose Tissue and in Circulation

(2010) Nadia Naour et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Specialized roles for cysteine cathepsins in health and disease

(2010) Jochen Reiser et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

(2010) P. Horak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

(2009) Daphne P Guh et al.   BMC PUBLIC HEALTH

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis

(2009) R. E. Burden et al.   CLINICAL CANCER RESEARCH

An Adiponectin-Like Molecule with Antidiabetic Properties

(2009) Thierry Sulpice et al.   ENDOCRINOLOGY

Current strategies for the inhibition of hepatic glucose production in type 2 diabetes

(2009) Dale et al.   Frontiers in Bioscience-Landmark

Deficiency and Inhibition of Cathepsin K Reduce Body Weight Gain and Increase Glucose Metabolism in Mice

(2008) Min Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

(2008) D. M. Nathan et al.   DIABETES CARE

Cysteine cathepsin proteases as pharmacological targets in cancer

(2007) Carmela Palermo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES