Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia

Hypoxia-Induced Energy Stress Inhibits the mTOR Pathway by Activating an AMPK/REDD1 Signaling Axis in Head and Neck Squamous Cell Carcinoma

(2015) Abraham Schneider et al.   NEOPLASIA

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death

(2011) B Kucejova et al.   ONCOGENE

Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1,

(2010) Silvia Vega-Rubin-de-Celis et al.   BIOCHEMISTRY

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

miR-221 overexpression contributes to liver tumorigenesis

(2009) P. Pineau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

Amino acid regulation of TOR complex 1

(2008) Joseph Avruch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mammalian target of rapamycin as a therapeutic target in oncology

(2008) Robert T Abraham et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Activation of HIF-1α in exponentially growing cells via hypoxic stimulation is independent of the Akt/mTOR pathway

(2008) Frédéric Dayan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An RNA Interference Screen Identifies a Novel Regulator of Target of Rapamycin That Mediates Hypoxia Suppression of Translation in Drosophila S2 Cells

(2008) Soo-Jung Lee et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Silibinin inhibits hypoxia-inducible factor-1α and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy

(2008) P García-Maceira et al.   ONCOGENE

Mesenchymal-epithelial interactions involving epiregulin in tuberous sclerosis complex hamartomas

(2008) S. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency

(2008) Michaël G. Magagnin et al.   PROTEOMICS