Short chain fatty acids and methylamines produced by gut microbiota as mediators and markers in the circulatory system

Trimethylamine N-Oxide and Cardiovascular Outcomes in Patients with End-stage Kidney Disease Receiving Maintenance Hemodialysis

(2019) Jason R. Stubbs et al.   Clinical Journal of the American Society of Nephrology

Shaping the Gut Microbiota by Breastfeeding: The Gateway to Allergy Prevention?

(2019) Lieke W. J. van den Elsen et al.   Frontiers in Pediatrics

Microbiome–metabolome reveals the contribution of gut–kidney axis on kidney disease

(2019) Yuan-Yuan Chen et al.   Journal of Translational Medicine

Utility of Plasma Concentration of Trimethylamine N-Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes

(2019) Signe A. Winther et al.   DIABETES CARE

Perspective: Physiologic Importance of Short-Chain Fatty Acids from Nondigestible Carbohydrate Fermentation

(2019) Celeste Alexander et al.   Advances in Nutrition

Trimethylamine N-Oxide Does Not Impact Viability, ROS Production, and Mitochondrial Membrane Potential of Adult Rat Cardiomyocytes

(2019) Querio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbiota-Derived Components and Metabolites in the Progression of Non-Alcoholic Fatty Liver Disease (NAFLD)

(2019) Yun Ji et al.   Nutrients

TMA (trimethylamine), but not its oxide TMAO (trimethylamine-oxide), exerts hemodynamic effects - implications for interpretation of cardiovascular actions of gut microbiome.

(2019) Kinga Jaworska et al.   CARDIOVASCULAR RESEARCH

Gut microbe-derived metabolite trimethylamine N-oxide accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis

(2019) Wenlong Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dietary Choline or Trimethylamine N-oxide Supplementation Does Not Influence Atherosclerosis Development in Ldlr−/− and Apoe−/− Male Mice

(2019) Paulina Aldana-Hernández et al.   JOURNAL OF NUTRITION

Trimethylamine But Not Trimethylamine Oxide Increases With Age in Rat Plasma and Affects Smooth Muscle Cells Viability

(2019) Kinga Jaworska et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Gut Microbial Metabolite Trimethylamine N-Oxide and Hypertension Risk: A Systematic Review and Dose–Response Meta-analysis

(2019) Xinyu Ge et al.   Advances in Nutrition

Combined use of trimethylamine N-oxide with BNP for risk stratification in heart failure with preserved ejection fraction: findings from the DIAMONDHFpEF study

(2019) Andrea Salzano et al.   European Journal of Preventive Cardiology

TMA, A Forgotten Uremic Toxin, but Not TMAO, Is Involved in Cardiovascular Pathology

(2019) Kinga Jaworska et al.   Toxins

Propionic acid counteracts the inflammation of human subcutaneous adipose tissue: a new avenue for drug development

(2019) Sa’ad Al-Lahham et al.   DARU-Journal of Pharmaceutical Sciences

Gut Microbes Role in Heart Failure Explored

(2019) Bridget M. Kuehn   CIRCULATION

Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors

(2019) Maksymilian Onyszkiewicz et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Gut Microbiota–Dependent TrimethylamineN-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes

(2018) Arash Haghikia et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway

(2018) Jin Geng et al.   BIOMEDICINE & PHARMACOTHERAPY

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

(2018) Yilang Ke et al.   FREE RADICAL BIOLOGY AND MEDICINE

Trimethylamine N -oxide: A harmful, protective or diagnostic marker in lifestyle diseases?

(2018) Artur Nowiński et al.   NUTRITION

Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients

(2018) Xiao Cui et al.   Scientific Reports

In Vitro Modeling of Bile Acid Processing by the Human Fecal Microbiota

(2018) Glynn Martin et al.   Frontiers in Microbiology

Indole, a Signaling Molecule Produced by the Gut Microbiota, Negatively Impacts Emotional Behaviors in Rats

(2018) Mathilde Jaglin et al.   Frontiers in Neuroscience

Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

(2018) Zehua Li et al.   LABORATORY INVESTIGATION

Serum Trimethylamine N-Oxide Concentration Is Positively Associated With First Stroke in Hypertensive Patients

(2018) Jing Nie et al.   STROKE

The mammalian mycobiome: A complex system in a dynamic relationship with the host

(2018) Ghee Chuan Lai et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Relation of Circulating Trimethylamine N-Oxide With Coronary Atherosclerotic Burden in Patients With ST-segment Elevation Myocardial Infarction

(2018) Zhaoxue Sheng et al.   AMERICAN JOURNAL OF CARDIOLOGY

Serum gut microbe-dependent trimethylamine N-oxide improves the prediction of future cardiovascular disease in a community-based general population

(2018) Liqiang Zheng et al.   ATHEROSCLEROSIS

Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations

(2018) Nhan T. Ho et al.   Nature Communications

Gut microbiota functions: metabolism of nutrients and other food components

(2017) Ian Rowland et al.   EUROPEAN JOURNAL OF NUTRITION

Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin–angiotensin system

(2017) Lei Wang et al.   JOURNAL OF HYPERTENSION

The gut-blood barrier permeability – A new marker in cardiovascular and metabolic diseases?

(2017) Marcin Ufnal et al.   MEDICAL HYPOTHESES

Associations of current diet with plasma and urine TMAO in the KarMeN study: direct and indirect contributions

(2017) Ralf Krüger et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The importance of appropriate initial bacterial colonization of the intestine in newborn, child, and adult health

(2017) W Allan Walker   PEDIATRIC RESEARCH

Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite

(2017) Kinga Jaworska et al.   PLoS One

Rodents and humans are able to detect the odour of L-Lactate

(2017) Valentina Mosienko et al.   PLoS One

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria

(2017) Marina Makrecka-Kuka et al.   TOXICOLOGY LETTERS

Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance

(2017) Sean McNabney et al.   Nutrients

The intestinal barrier: a fundamental role in health and disease

(2017) Maaike Vancamelbeke et al.   Expert Review of Gastroenterology & Hepatology

Uncovering the trimethylamine-producing bacteria of the human gut microbiota

(2017) Silke Rath et al.   Microbiome

Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

(2017) Takehiro Kamo et al.   PLoS One

TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function

(2017) Eke G. Gruppen et al.   Scientific Reports

L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP

(2016) Heidi L. Collins et al.   ATHEROSCLEROSIS

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Hypertension-Linked Pathophysiological Alterations in the GutNovelty and Significance

(2016) Monica M. Santisteban et al.   CIRCULATION RESEARCH

Trimethylamine N -oxide and Risk Stratification after Acute Myocardial Infarction

(2016) Toru Suzuki et al.   CLINICAL CHEMISTRY

Increased Systolic and Diastolic Blood Pressure Is Associated With Altered Gut Microbiota Composition and Butyrate Production in Early PregnancyNovelty and Significance

(2016) Luisa F. Gomez-Arango et al.   HYPERTENSION

Microbiota-Dependent Marker TMAO Is Elevated in Silent Ischemia but Is Not Associated With First-Time Myocardial Infarction in HIV Infection

(2016) Judith M. Haissman et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Plasma Trimethylamine N -Oxide, a Gut Microbe–Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden

(2016) Vichai Senthong et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

TrimethylamineN-Oxide and Cardiovascular Events in Hemodialysis Patients

(2016) Tariq Shafi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events

(2016) Richard B. Kim et al.   KIDNEY INTERNATIONAL

Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis

(2016) Lenka Tomasova et al.   MOLECULES

Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

(2016) Megan W. Bourassa et al.   NEUROSCIENCE LETTERS

Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

(2016) Ming-liang Chen et al.   mBio

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Intestinal Microbiota‐Generated Metabolite Trimethylamine‐N‐Oxide and 5‐Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE‐Like Patient Cohort

(2016) Vichai Senthong et al.   Journal of the American Heart Association

Microbiota‐Dependent Metabolite Trimethylamine N‐Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)

(2016) Katie A. Meyer et al.   Journal of the American Heart Association

Trimethylamine N ‐Oxide and Mortality Risk in Patients With Peripheral Artery Disease

(2016) Vichai Senthong et al.   Journal of the American Heart Association

Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease

(2016) Catharina Missailidis et al.   PLoS One

Plaque burden in HIV-infected patients is associated with serum intestinal microbiota-generated trimethylamine

(2015) Suman Srinivasa et al.   AIDS

Sex Differences in Platelet Toll-Like Receptors and Their Association With Cardiovascular Risk FactorsSignificance

(2015) Milka Koupenova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control

(2015) Daniel M. Mueller et al.   ATHEROSCLEROSIS

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart FailureCLINICAL PERSPECTIVE

(2015) Chelsea L. Organ et al.   Circulation-Heart Failure

The role of acetic acid on glucose uptake and blood flow rates in the skeletal muscle in humans with impaired glucose tolerance

(2015) P Mitrou et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Vinegar decreases blood pressure by down-regulating AT1R expression via the AMPK/PGC-1α/PPARγ pathway in spontaneously hypertensive rats

(2015) Lixin Na et al.   EUROPEAN JOURNAL OF NUTRITION

Olfaction in the kidney: ‘smelling’ gut microbial metabolites

(2015) Niranjana Natarajan et al.   EXPERIMENTAL PHYSIOLOGY

Gut Dysbiosis Is Linked to HypertensionNovelty and Significance

(2015) Tao Yang et al.   HYPERTENSION

Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure

(2015) W.H. Wilson Tang et al.   JOURNAL OF CARDIAC FAILURE

Oral L-Carnitine Supplementation Increases Trimethylamine-N-oxide but Reduces Markers of Vascular Injury in Hemodialysis Patients

(2015) Kei Fukami et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Associations of Trimethylamine N-Oxide With Nutritional and Inflammatory Biomarkers and Cardiovascular Outcomes in Patients New to Dialysis

(2015) George A. Kaysen et al.   JOURNAL OF RENAL NUTRITION

Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden

(2015) J. R. Stubbs et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evidence for a link between gut microbiota and hypertension in the Dahl rat

(2015) Blair Mell et al.   PHYSIOLOGICAL GENOMICS

Dysbiosis of Gut Microbiota With Reduced Trimethylamine‐N‐Oxide Level in Patients With Large‐Artery Atherosclerotic Stroke or Transient Ischemic Attack

(2015) Jia Yin et al.   Journal of the American Heart Association

Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes

(2015) Panayota Mitrou et al.   Journal of Diabetes Research

Metabolomic Fingerprint of Heart Failure with Preserved Ejection Fraction

(2015) Beshay N. Zordoky et al.   PLoS One

γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L -Carnitine to TMAO

(2014) Robert A. Koeth et al.   Cell Metabolism

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

(2014) Jill C. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

(2014) M. Trøseid et al.   JOURNAL OF INTERNAL MEDICINE

The Effects of Propionate and Valerate on Insulin Responsiveness for Glucose Uptake in 3T3-L1 Adipocytes and C2C12 Myotubes via G Protein-Coupled Receptor 41

(2014) Joo-Hui Han et al.   PLoS One

Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO)

(2014) J. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Propionic acid and butyric acid inhibit lipolysis and de novo lipogenesis and increase insulin-stimulated glucose uptake in primary rat adipocytes

(2014) Emilia Heimann et al.   Adipocyte

Butyrate and Colorectal Cancer: The Role of Butyrate Transport

(2013) Pedro Gonçalves et al.   CURRENT DRUG METABOLISM

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interpersonal and intrapersonal diversity of human-associated microbiota in key body sites

(2012) Luke K. Ursell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Normal and Pathologic Concentrations of Uremic Toxins

(2012) F. Duranton et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects

(2011) Sa’ad Al-Lahham et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

(2011) Roberto Berni Canani   WORLD JOURNAL OF GASTROENTEROLOGY

Butyrate, an HDAC inhibitor, stimulates interplay between different posttranslational modifications of histone H3 and differently alters G1-specific cell cycle proteins in vascular smooth muscle cells

(2010) Omana P. Mathew et al.   BIOMEDICINE & PHARMACOTHERAPY

Vinegar Intake Enhances Flow-Mediated VasodilatationviaUpregulation of Endothelial Nitric Oxide Synthase Activity

(2010) Syoji SAKAKIBARA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Epilepsy and trimethylaminuria: A new case report and literature review

(2010) Alessandro Pellicciari et al.   BRAIN & DEVELOPMENT

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

Sequence Polymorphisms Provide a Common Consensus Sequence for GPR41 and GPR42

(2009) Chen W. Liaw et al.   DNA AND CELL BIOLOGY

Propionic acid production by cofermentation of Lactobacillus buchneri and Lactobacillus diolivorans in sourdough

(2009) Chonggang Zhang et al.   FOOD MICROBIOLOGY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA