Article
Biochemistry & Molecular Biology
Yuhang Huang, Fanjie Lin, Ruidi Tang, Changlei Bao, Qingxun Zhou, Kaiwen Ye, Yi Shen, Chunli Liu, Cheng Hong, Kai Yang, Haiyang Tang, Jian Wang, Wenju Lu, Tao Wang
Summary: The study demonstrates that elevated levels of TMAO are associated with severe PH, and reducing TMAO can decrease pulmonary vascular muscularization and alleviate PH. Additionally, TMAO can promote the production of chemokines and cytokines by suppressing macrophages.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Analytical
Yu-Chun Chang, Yi-Hsuan Chu, Chien-Cheng Wang, Chih-Hsuan Wang, You-Lin Tain, Hung-Wei Yang
Summary: The gut microbiota-derived metabolites TMAO and TMA play a critical role in CKD and hypertension. A new color-switch method was developed for the direct quantitative detection of TMAO in whole blood, showing potential clinical applications in blood TMAO monitoring for CKD patients.
Review
Nutrition & Dietetics
Doudou Li, Ying Lu, Shuai Yuan, Xiaxia Cai, Yuan He, Jie Chen, Qiong Wu, Di He, Aiping Fang, Yacong Bo, Peige Song, Debby Bogaert, Kostas Tsilidis, Susanna C. Larsson, Huanling Yu, Huilian Zhu, Evropi Theodoratou, Yimin Zhu, Xue Li
Summary: This study aimed to summarize the health outcomes related to circulating TMAO concentrations. It identified 6 associations with highly suggestive evidence, suggesting that TMAO may be a novel biomarker for human health conditions including all-cause mortality, hypertension, cardiovascular diseases, diabetes mellitus, cancer, and kidney function.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Physiology
Katongo H. Mutengo, Sepiso K. Masenga, Aggrey Mweemba, Wilbroad Mutale, Annet Kirabo
Summary: The human gut microbiota and its dependant metabolite, trimethylamine N-oxide, play significant roles in the development of hypertension. This review examines the impact of the gut microbiota and trimethylamine N-oxide on hypertension pathogenesis, providing evidence from both human and animal studies. New insights into potential therapies for managing hypertension by altering the gut microbiota are also discussed.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Jing Zhen, Zhou Zhou, Meng He, Hai-Xiang Han, En-Hui Lv, Peng-Bo Wen, Xin Liu, Yan-Ting Wang, Xun-Chao Cai, Jia-Qi Tian, Meng-Ying Zhang, Lei Xiao, Xing-Xing Kang
Summary: Cardiovascular diseases (CVDs) are highly prevalent worldwide, and the balance of intestinal microecology plays a crucial role in their occurrence and development. Trimethylamine N-oxide (TMAO), a metabolite produced by gut microbiota from dietary choline and L-carnitine, has been found to inhibit cholesterol metabolism, induce platelet aggregation, and promote atherosclerosis. This review provides insights into the biological and chemical characteristics of TMAO, as well as its impact on various CVDs, including atherosclerosis, heart failure, hypertension, arrhythmia, and coronary artery disease. Understanding the mechanism of TMAO in promoting CVDs may contribute to the development of targeted therapies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Adhini Kuppuswamy Satheesh Babu, Chrissa Petersen, Lisard Iglesias-Carres, Henry A. Paz, Umesh D. Wankhade, Andrew P. Neilson, Pon Velayutham Anandh Babu
Summary: This study investigated the effects of dietary blueberries and strawberries on the production of TMAO, a metabolite associated with various diseases. The results showed that blueberry supplementation reduced circulating TMAO levels, while strawberry supplementation did not have this effect. Antibiotics drastically reduced TMA and TMAO levels. Blueberry supplementation also increased the abundance of bacteria that are negatively associated with TMAO.
Article
Nutrition & Dietetics
Seok Jong Chung, John Hoon Rim, Dajeong Ji, Sangwon Lee, Han Soo Yoo, Jin Ho Jung, KyoungWon Baik, Yonghoon Choi, Byoung Seok Ye, Young H. Sohn, Mijin Yun, Sang-Guk Lee, Phil Hyu Lee
Summary: This study found that lower baseline plasma TMAO levels are associated with faster increases in LED and tend to increase the risk for PD-dementia conversion, suggesting the prognostic implications of TMAO in early stage PD.
Review
Geriatrics & Gerontology
Rui Huang, Li Yan, Yuhua Lei
Summary: Accumulating evidence suggests that TMAO is crucial in the pathogenesis of cardiovascular diseases, including atrial fibrillation. Intervening in the metabolic pathway of TMAO and personalized treatment strategies may be beneficial for AF patients, especially those with high serum TMAO concentrations. Further research, including preclinical studies and randomized controlled trials, is needed to establish the essential relationship between TMAO and AF.
CLINICAL INTERVENTIONS IN AGING
(2021)
Article
Neurosciences
Sankar Simla Praveenraj, Sharma Sonali, Nikhilesh Anand, Hediyal Ahmed Tousif, Chandrasekaran Vichitra, Manjunath Kalyan, Perumalswamy Velumani Kanna, Kumar A. Chandana, Paneyala Shasthara, Arehally M. Mahalakshmi, Jian Yang, Seithikurippu R. Pandi-Perumal, Meena Kishore Sakharkar, Saravana Babu Chidambaram
Summary: Trimethylamine lyases are enzymes expressed in intestinal microbiota that metabolize dietary nutrients to produce trimethylamine (TMA). Trimethylamine N-oxide (TMAO) is a product of TMA metabolism and has been shown to contribute to the development of metabolic, cardiovascular, and cerebrovascular diseases. This manuscript summarizes the harmful effects of TMAO on neurodegenerative and sleep disorders, as well as its predictive role in neurological disorders. Mechanisms such as activation of inflammatory signaling pathways and mitochondrial dysfunction are involved in TMAO-mediated pathogenesis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Jose L. Flores-Guerrero, Maryse C. J. Oste, Paula B. Baraldi, Margery A. Connelly, Erwin Garcia, Gerjan Navis, Stephan J. L. Bakker, Robin P. F. Dullaart
Summary: This study revealed that trimethylamine-N-oxide (TMAO) and its dietary determinants are associated with an increased risk of graft failure in renal transplant recipients (RTRs). A predictive model enriched with TMAO and dietary factors showed a higher Net Benefit compared to a previously validated model.
Article
Nutrition & Dietetics
Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Chiara Graziadio, Maria Maisto, Francesca Pivari, Andrea Falco, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano
Summary: Individual differences in chronotype are associated with cardiometabolic risk and gut dysbiosis. Morning chronotype is linked to lower BMI, better metabolic profile, higher adherence to the Mediterranean diet, and lower circulating TMAO concentrations. Higher chronotype scores are mainly associated with lower TMAO concentrations.
Article
Dermatology
Mariusz Sikora, Norbert Kiss, Albert Stec, Joanna Giebultowicz, Emilia Samborowska, Radoslaw Jazwiec, Michal Dadlez, Malgorzata Olszewska, Lidia Rudnicka
Summary: The study found that TMAO concentration was significantly higher in patients with psoriasis compared to the control group, and was significantly correlated with age, total cholesterol, triglycerides, systolic and diastolic blood pressure. The ROC and multiple regression analysis showed that TMAO is an independent predictor of cardiovascular risk.
DERMATOLOGY AND THERAPY
(2021)
Review
Nutrition & Dietetics
Mauro Lombardo, Giovanni Aulisa, Daniele Marcon, Gianluca Rizzo, Maria Grazia Tarsisano, Laura Di Renzo, Massimo Federici, Massimiliano Caprio, Antonino De Lorenzo
Summary: There is a strong correlation between TMAO and fish consumption, particularly saltwater fish and shellfish, while the associations of TMAO with eggs, dairy, and meat are less clear. Plant-based foods do not seem to influence TMAO levels significantly, but this area requires further investigation.
Article
Medicine, General & Internal
Jose L. Flores-Guerrero, Peter R. van Dijk, Margery A. Connelly, Erwin Garcia, Henk J. G. Bilo, Gerjan Navis, Stephan J. L. Bakker, Robin P. F. Dullaart
Summary: Research showed that high plasma TMAO concentrations in patients with T2D are associated with an increased risk of cardiovascular mortality, while BCAA concentrations are not.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Marina Canyelles, Melania Plaza, Noemi Rotllan, Dolors Llobet, Josep Julve, Sergi Mojal, Maribel Diaz-Ricart, Jose Manuel Soria, Joan Carles Escola-Gil, Mireia Tondo, Francisco Blanco-Vaca, Joan Carles Souto
Summary: This study found no differences in the concentrations of TMAO, gamma BB, and TML between controls and VTE patients. Thrombin generation tests showed a positive correlation with time parameters, but a negative correlation with peak height for these metabolites. There was no correlation between these gut metabolites and platelet function parameters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Rulin Zhuang, Xinyu Ge, Lu Han, Ping Yu, Xin Gong, Qingshu Meng, Yuzhen Zhang, Huimin Fan, Liang Zheng, Zhongmin Liu, Xiaohui Zhou
Article
Cell & Tissue Engineering
Xiaoting Liang, Jing Liu, Mimi Li, Fang Lin, Rulin Zhuang, Qingshu Meng, Xiaoxue Ma, Yuanfeng Xin, Xin Gong, Zhiying He, Wei Han, Xiaohui Zhou, Zhongmin Liu
Summary: Overactive inflammatory responses contribute to cardiac dysfunction after myocardial infarction (MI). Intravenous administration of human umbilical cord-derived MSC (HucMSC) can improve cardiac performance and prevent adverse remodeling after MI by exerting systemic and local anti-inflammatory effects. HucMSC mediates systemic and local T cell interchange, inhibiting T cell infiltration in the infarcted heart and mediastinal lymph nodes (med-LN), which contributes to the improvement of cardiac function after MI.
STEM CELLS INTERNATIONAL
(2023)
