From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

(2019) Nicolas Damond et al.   Cell Metabolism

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

(2019) Yue J. Wang et al.   Cell Metabolism

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes

(2019) Peter J. Thompson et al.   Cell Metabolism

Looking back and looking forward: A brief history of research into type 1 diabetes

(2019) R. David Leslie et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Residual β cell function and monogenic variants in long-duration type 1 diabetes patients

(2019) Marc Gregory Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophils in tissue injury and repair

(2018) Jing Wang   CELL AND TISSUE RESEARCH

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

(2018) Alexandra Coomans de Brachène et al.   DIABETOLOGIA

Alpha cell dysfunction in type 1 diabetes

(2018) Gina L.C. Yosten   PEPTIDES

Decreased α-cell mass and early structural alterations of the exocrine pancreas in patients with type 1 diabetes: An analysis based on the nPOD repository

(2018) Fidéline Bonnet-Serrano et al.   PLoS One

Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes

(2018) Kevin C. Osum et al.   Scientific Reports

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

(2018) Marcela Brissova et al.   Cell Reports

Modeling human pancreatic beta cell dedifferentiation

(2018) Marc Diedisheim et al.   Molecular Metabolism

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

(2018) Sergio Gonzalez-Duque et al.   Cell Metabolism

The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms

(2018) Pia Leete et al.   Current Diabetes Reports

Beta Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes

(2018) Elad Horwitz et al.   DIABETES

Reduction in White Blood Cell, Neutrophil and Red Blood Cell counts Related to Gender, HLA and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes

(2018) Falastin Salami et al.   DIABETES

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells

(2018) Eseoghene Ifie et al.   DIABETOLOGIA

Immunological biomarkers for the development and progression of type 1 diabetes

(2018) Chantal Mathieu et al.   DIABETOLOGIA

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

(2018) Maikel L. Colli et al.   EBioMedicine

Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children

(2018) David Endesfelder et al.   DIABETES

Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes

(2018) Martha L. Campbell-Thompson et al.   DIABETES CARE

The Emerging Role of Neutrophil Granulocytes in Multiple Sclerosis

(2018) Tonia Woodberry et al.   Journal of Clinical Medicine

Alpha cells, the main source of IL-1β in human pancreas

(2017) Florence Anquetil et al.   JOURNAL OF AUTOIMMUNITY

β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis

(2017) Carol J Lam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreatic islet inflammation: an emerging role for chemokines

(2017) J Jason Collier et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children

(2017) Anita Kondrashova et al.   PEDIATRIC DIABETES

Islet amyloid in recent-onset type 1 diabetes—the DiViD study

(2017) Gunilla T. Westermark et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

The density of parasympathetic axons is reduced in the exocrine pancreas of individuals recently diagnosed with type 1 diabetes

(2017) Marcus Lundberg et al.   PLoS One

Pancreatic size and fat content in diabetes: A systematic review and meta-analysis of imaging studies

(2017) Tiago Severo Garcia et al.   PLoS One

Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression

(2017) Guido Sebastiani et al.   Scientific Reports

Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells

(2016) Tatiana Takiishi et al.   DIABETES

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

(2016) Pia Leete et al.   DIABETES

Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis

(2016) Jay S. Skyler et al.   DIABETES

Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes

(2016) Marcus Lundberg et al.   DIABETES

Pancreas volume and fat fraction in children with Type 1 diabetes

(2016) S. E. Regnell et al.   DIABETIC MEDICINE

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity

(2016) Ezio Bonifacio et al.   DIABETOLOGIA

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

(2016) Jenny Aurielle B Babon et al.   NATURE MEDICINE

Diabetes Mellitus Is Associated With an Exocrine Pancreatopathy

(2016) Sonmoon Mohapatra et al.   PANCREAS

Insulitis in the pathogenesis of type 1 diabetes

(2016) Alberto Pugliese   PEDIATRIC DIABETES

Use of the Electronic Medical Record to Assess Pancreas Size in Type 1 Diabetes

(2016) John Virostko et al.   PLoS One

The CXCR1/2 Pathway: Involvement in Diabetes Pathophysiology and Potential Target for T1D Interventions

(2015) Antonio Citro et al.   Current Diabetes Reports

Towards an Earlier and Timely Diagnosis of Type 1 Diabetes: Is it Time to Change Criteria to Define Disease Onset?

(2015) Manuela Battaglia et al.   Current Diabetes Reports

Abnormalities of the Exocrine Pancreas in Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   Current Diabetes Reports

Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro

(2015) Lars Krogvold et al.   DIABETES

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

The influence of type 1 diabetes on pancreatic weight

(2015) Martha L. Campbell-Thompson et al.   DIABETOLOGIA

Mast cells infiltrate pancreatic islets in human type 1 diabetes

(2015) Luisa Martino et al.   DIABETOLOGIA

Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes

(2015) Lars Krogvold et al.   DIABETOLOGIA

Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice

(2015) Daniela Carlos et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase

(2015) Teresa Rodriguez-Calvo et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Organ donor specimens: What can they tell us about type 1 diabetes?

(2015) Martha Campbell-Thompson   PEDIATRIC DIABETES

Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients

(2015) Jason L. Gaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A run on the biobank

(2015) John S. Kaddis et al.   Current Opinion in Endocrinology Diabetes and Obesity

New Insight on Human Type 1 Diabetes Biology: nPOD and nPOD-Transplantation

(2014) Alberto Pugliese et al.   Current Diabetes Reports

CXCR3, CXCL10 and type 1 diabetes

(2014) Alessandro Antonelli et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes

(2014) Lars Krogvold et al.   DIABETES

Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes

(2014) Teresa Rodriguez-Calvo et al.   DIABETES

Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

(2014) Sefina Arif et al.   DIABETES

Evolution of Abnormal Plasma Glucagon Responses to Mixed-Meal Feedings in Youth With Type 1 Diabetes During the First 2 Years After Diagnosis: Figure 1

(2014) Jennifer Sherr et al.   DIABETES CARE

Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study

(2014) Lars Krogvold et al.   DIABETOLOGIA

Macrophages and  -cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes

(2014) J. Diana et al.   EMBO Molecular Medicine

Pancreatic Pathology in Type 1 Diabetes Mellitus

(2014) Sarah J. Richardson et al.   ENDOCRINE PATHOLOGY

Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

(2014) Charlotte Giesen et al.   NATURE METHODS

Immune modulation in humans: implications for type 1 diabetes mellitus

(2014) Bart O. Roep et al.   Nature Reviews Endocrinology

The multifactorial role of neutrophils in rheumatoid arthritis

(2014) Helen L. Wright et al.   Nature Reviews Rheumatology

Insulitis in human type 1 diabetes: a comparison between patients and animal models

(2014) Peter In’t Veld   Seminars in Immunopathology

Functional Redundancy of CXCR3/CXCL10 Signaling in the Recruitment of Diabetogenic Cytotoxic T Lymphocytes to Pancreatic Islets in a Virally Induced Autoimmune Diabetes Model

(2013) K. T. Coppieters et al.   DIABETES

 -Cells, Autoimmunity, and the Innate Immune System: "un Menage a Trois"?

(2013) B. O. Roep   DIABETES

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

(2013) A. Valle et al.   DIABETES

Increased Complement Activation in Human Type 1 Diabetes Pancreata

(2013) P. Rowe et al.   DIABETES CARE

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

(2013) Anette G. Ziegler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

The case for virus-induced type 1 diabetes

(2013) Isabella Spagnuolo et al.   Current Opinion in Endocrinology Diabetes and Obesity

Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes

(2012) Martha Campbell-Thompson et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Imaging of β-Cell Mass and Insulitis in Insulin-Dependent (Type 1) Diabetes Mellitus

(2012) Valentina Di Gialleonardo et al.   ENDOCRINE REVIEWS

Pancreatic Volume Is Reduced in Adult Patients with Recently Diagnosed Type 1 Diabetes

(2012) Alistair J. K. Williams et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Mast Cells are Important Modifiers of Autoimmune Disease: With so Much Evidence, Why is There Still Controversy?

(2012) Melissa A. Brown et al.   Frontiers in Immunology

New insights into the role of mast cells in autoimmunity: Evidence for a common mechanism of action?

(2011) Margaret E. Walker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell function

(2011) F. A. Grieco et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes

(2011) S. A. Sarkar et al.   DIABETES

Insulitis in human type 1 diabetes

(2011) Peter In't Veld   Islets

The islet-acinar axis of the pancreas: more than just insulin

(2010) Savio G. Barreto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Islet inflammation and CXCL10 in recent-onset type 1 diabetes

(2010) B. O. Roep et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

 -Cell Replication Is Increased in Donor Organs From Young Patients After Prolonged Life Support

(2010) P. I. Veld et al.   DIABETES

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes

(2010) A. Willcox et al.   DIABETOLOGIA

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients

(2010) Jason L. Gaglia et al.   JOURNAL OF CLINICAL INVESTIGATION

Dietary Intervention in Infancy and Later Signs of Beta-Cell Autoimmunity

(2010) Mikael Knip et al.   NEW ENGLAND JOURNAL OF MEDICINE

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES