Article
Endocrinology & Metabolism
Steffen U. Thorsen, Xiang Liu, Yachana Kataria, Thomas Mandrup-Poulsen, Simranjeet Kaur, Ulla Uusitalo, Suvi M. Virtanen, Jill M. Norris, Marian Rewers, William Hagopian, Jimin Yang, Jin-Xiong She, Beena Akolkar, Stephen Rich, Carin Andren Aronsson, Ake Lernmark, Anette-Gabriele Ziegler, Jorma Toppari, Jeffrey Krischer, Hemang M. Parikh, Christina Ellervik, Jannet Svensson
Summary: It is found that iron intake and genetically determined iron overload may interact in predisposing to the development of childhood islet autoimmunity and type 1 diabetes. A U-shaped association between iron intake and risk of GAD antibody as the first autoantibody in children was found. High iron intake was associated with an increased risk of IA with insulin as the first autoantibody in children with 2 or more iron risk alleles.
Article
Engineering, Biomedical
Catherine E. Majors, Michal E. Pawlowski, Tomasz S. Tkaczyk, Queen Dube, Rebecca Richards-Kortum
Summary: The study demonstrates that LeukoScope can assist in measuring WBC counts in pediatric patients but faces challenges in accurately assessing WBC counts in neonatal patients.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Pediatrics
Sachin Singh, Prawin Kumar, Jagdish Prasad Goyal, Kuldeep Singh
Summary: High lung function is associated with good asthma control. High absolute eosinophil counts (AEC) are associated with better asthma control, while high absolute neutrophil counts (ANC) are associated with poor asthma control.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Vibha Anand, Ying Li, Bin Liu, Mohamed Ghalwash, Eileen Koski, Kenney Ng, Jessica L. Dunne, Josefine Jonsson, Christiane Winkler, Mikael Knip, Jorma Toppari, Jorma Ilonen, Michael B. Killian, Brigitte I. Frohnert, Markus Lundgren, Anette-Gabriele Ziegler, William Hagopian, Riitta Veijola, Marian Rewers
Summary: The study shows that the number of islet autoantibodies at seroconversion can reliably predict the 15-year risk of type 1 diabetes. In children with a single autoantibody, HLA-DR-DQ genotypes can further refine the risk of progression. Additionally, the age at which multiple autoantibodies develop can impact the rate of progression to diabetes.
Article
Endocrinology & Metabolism
Ulla Uusitalo, Lazarus K. Mramba, Carin Andren Aronsson, Kendra Vehik, Jimin Yang, Sandra Hummel, Ake Lernmark, Marian Rewers, William Hagopian, Richard Mcindoe, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Suvi M. Virtanen, Jill M. Norris, TEDDY Study Grp
Summary: This study aimed to investigate the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to the risk of islet autoimmunity (IA). The results showed that early introduction of solid foods (<6 months) was associated with increased IA risk in children with the HLA DR3/4 genotype and no probiotic exposure during the first year of life. Introducing rice at 4-5.9 months, compared to other time periods in the US, was also associated with an increased risk of IA.
Article
Medicine, General & Internal
Moti Klein, Lior Hassan, Rivka Katz, Ran Abuhasira, Matthew Boyko, Ohad Gabay, Dmitry Frank, Yair Binyamin, Victor Novack, Amit Frenkel
Summary: Critically ill patients with sepsis often require packed cell transfusions, which may affect white blood cell counts. A retrospective cohort study involving 962 patients who received packed cell transfusions and 994 matched control patients found that the mean white blood cell count decreased in both groups, but more in the non-transfusion group. Linear regression analysis showed that the increase in white blood cell count before transfusion was associated with a decrease in the final white blood cell count. Overall, packed cell transfusions cause only mild and clinically non-prominent changes in white blood cell count among critically ill patients with sepsis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Xiang Liu, Suzanne Bennett Johnson, Kristian F. Lynch, Kerry Cordan, Russell Pate, Martha D. Butterworth, Ake Lernmark, William A. Hagopian, Marian J. Rewers, Richard A. McIndoe, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Jimin Yang, TEDDY Study Grp
Summary: This study found that increasing the daily duration of moderate to vigorous physical activity can reduce the risk of developing type 1 diabetes in children aged 5-15 who have multiple islet autoantibodies.
Article
Agriculture, Dairy & Animal Science
R. Lindenwald, H. -J. Schuberth, B. Spindler, S. Rautenschlein
Summary: Turkeys housed in poorly structured commercial environments often experience stress and behavioral issues. This study found that environmental enrichment can improve behavioral repertoire and health parameters in turkeys, suggesting a potential modulatory effect on immunity and overall fitness. Further research is needed to understand the relationship between behavior and health parameters in more detail.
Article
Endocrinology & Metabolism
Falastin Salami, Roy N. Tamura, Helena Elding Larsson, Ake Lernmark, Carina Torn
Summary: In children with increased genetic risk for type 1 diabetes and positive for islet autoantibodies, HbA1c increased over time with the number of autoantibodies. Changes in red blood cell indices were associated with increases in HbA1c and fasting glucose levels, while changes in other CBC parameters were associated with increases in fasting insulin levels. This suggests a potential link between CBC changes and deteriorating glucose metabolism in children with islet beta-cell autoimmunity.
ENDOCRINOLOGY DIABETES & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Guo-Qiang Pan, Chun-Cheng Yang, Xiao-ling Shang, Zhao-Ru Dong, Tao Li
Summary: This study found that genetically predicted lower total basophil neutrophil counts might be an independent risk factor for HCC in the European population.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Christian Lundtoft, Daniel Eriksson, Matteo Bianchi, Maribel Aranda-Guillen, Nils Landegren, Solbritt Rantapaa-Dahlqvist, Peter Soderkvist, Jeniffer R. S. Meadows, DISSECT Consortium, Immunoarray Consortium, Swedish Addison Registry Study Grp, Gerli Rosengren Pielberg, Sophie Bensing, Gerli Rosengren Pielberg, Kerstin Lindblad-Toh, Lars Ronnblom, Olle Kampe
Summary: Autoantibodies against the adrenal enzyme 21-hydroxylase are a hallmark manifestation in autoimmune Addison's disease (AAD). This study identified strong associations between copy number variants in the CYP21 region and the risk of AAD, most likely due to linkage disequilibrium with disease-associated HLA class II alleles.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Cell Biology
Brian S. Ferguson, Leslie E. Neidert, Matthew J. Rogatzki, Keith R. Lohse, L. Bruce Gladden, Heidi A. Kluess
Summary: The study found no significant difference in the release of ATP from RBCs of different densities under hypoxic and normoxic conditions, and the release of ATP was linearly correlated with the release of Hb.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Falastin Salami, Roy Tamura, Lu You, Ake Lernmark, Helena Elding Larsson, Markus Lundgren, Jeffrey Krischer, Anette-Gabriele Ziegler, Jorma Toppari, Riitta Veijola, Marian Rewers, Michael J. Haller, William Hagopian, Beena Akolkar, Carina Torn
Summary: The study found that increased levels of HbA1c were associated with a higher risk of type 1 diabetes, while a decrease in HbA1c levels predicted the development of IA-2A autoantibody. The trajectory of HbA1c can predict the appearance of autoantibodies and the onset of type 1 diabetes.
PEDIATRIC DIABETES
(2022)
Article
Clinical Neurology
Zhi-bing Hu, Ze-xiong Lu, Feng Zhu, Cao-qiang Jiang, Wei-sen Zhang, Jin Pan, Ya-li Jin, Lin Xu, G. Neil Thomas, Karkeung Cheng, Taihing Lam
Summary: The study found that the white blood cell count, especially the neutrophil count, is associated with an increased risk of fatal stroke in the elderly population. Additionally, dynamic changes in the WBC count and neutrophil count exceeding 25% are also related to an increased risk of fatal stroke occurrence.
Article
Medicine, General & Internal
Parisa Shiri Aghbash, Reyhaneh Rasizadeh, Milad Shirvaliloo, Javid Sadri Nahand, Hossein Bannazadeh Baghi
Summary: This study investigated the correlation between viral shedding in saliva and white blood cell count in COVID-19 patients. The results showed a significant increase in white blood cells, lymphocytes, and neutrophils on the 5th day in patients with sputum. The study proves that blood lymphocytes, as well as CRP, LDH, and ESR, can accurately indicate the amount of viral shedding in people with or without sputum.
FRONTIERS IN MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Maria Safura Mohamad, Balkish Mahadir Naidu, Suvi M. Virtanen, Susanna Lehtinen-Jacks, Khairul Nizam Abdul Maulud
Summary: Research has shown that the associations between access to local food and physical activity environments and overweight in children in Malaysia may vary depending on the state's overweight prevalence.
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
(2023)
Article
Nutrition & Dietetics
Leena Hakola, Anna-Leena Vuorinen, Hanna-Mari Takkinen, Sari Niinisto, Suvi Ahonen, Jenna Rautanen, Essi J. Peltonen, Jaakko Nevalainen, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Suvi M. Virtanen
Summary: This study aimed to investigate the associations between dietary intake of fatty acids in childhood and the risk of islet autoimmunity and type 1 diabetes (T1D). The results showed that higher intake of monounsaturated fatty acids, arachidonic acid, total n-3 fatty acids, and long-chain n-3 fatty acids was associated with a decreased risk of islet autoimmunity. Higher intake of total fat and saturated fatty acids was associated with a decreased risk of T1D only when energy adjusted.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Pediatrics
Vilma Kielevainen, Maaret Turtinen, Kristiina Luopajarvi, Taina Harkonen, Jorma Ilonen, Mikael Knip
Summary: A register-based retrospective cohort study of 4993 Finnish children diagnosed with type 1 diabetes revealed that HLA class II genes are associated with disease manifestation. Higher disease susceptibility is linked to younger age at diagnosis and shorter duration of symptoms before diagnosis.
Article
Endocrinology & Metabolism
Minna Harsunen, Jarno L. T. Kettunen, Taina Harkonen, Om Dwivedi, Mikko Lehtovirta, Paula Vahasalo, Riitta Veijola, Jorma Ilonen, Paivi J. Miettinen, Mikael Knip, Tiinamaija Tuomi
Summary: More than 10% of AAB-negative children with diabetes were found to have monogenic diabetes through genetic testing. Genetic diagnosis can lead to major changes in treatment, therefore, it is recommended to refer all AAB-negative pediatric diabetes patients for genetic testing.
Article
Ecology
Wisnu Adi Wicaksono, Aisa Buko, Peter Kusstatscher, Tomislav Cernava, Aki Sinkkonen, Olli H. Laitinen, Suvi M. Virtanen, Heikki Hyoety, Gabriele Berg
Summary: Vegetables and fruits are an important part of a healthy diet and their microbiomes are influenced by factors such as origin and cultivation methods. This study found significant differences in abundance, diversity, and community structures between apples and blueberries, which were strongly influenced by the growing system and country of origin. The study also identified specific taxonomic indicators for each group, highlighting the influence of horticultural management on the fruit microbiome. The findings suggest that the origin of fruits affects the diversity and composition of their microbiome, emphasizing the importance of considering the fruit microbiome as an external exposomic factor.
Article
Multidisciplinary Sciences
Pooja Mehta, Qian Li, Marisa Stahl, Ulla Uusitalo, Katri Lindfors, Martha D. Butterworth, Kalle Kurppa, Suvi Virtanen, Sibylle Koletzko, Carin Aronsson, William J. Hagopian, Marian Rewers, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey Krischer, Daniel Agardh, Edwin Liu
Summary: This study aimed to describe the adherence rates to a gluten-free diet in children with screening-identified celiac disease and determine the factors associated with adherence. The results showed that approximately two-thirds of the children remained strictly adherent to a gluten-free diet at 2 and 5 years after diagnosis. Parent-reported adherence did not correlate with actual gluten intake based on food records. Having a first-degree relative with celiac disease was associated with higher adherence.
Article
Endocrinology & Metabolism
Steffen U. Thorsen, Xiang Liu, Yachana Kataria, Thomas Mandrup-Poulsen, Simranjeet Kaur, Ulla Uusitalo, Suvi M. Virtanen, Jill M. Norris, Marian Rewers, William Hagopian, Jimin Yang, Jin-Xiong She, Beena Akolkar, Stephen Rich, Carin Andren Aronsson, Ake Lernmark, Anette-Gabriele Ziegler, Jorma Toppari, Jeffrey Krischer, Hemang M. Parikh, Christina Ellervik, Jannet Svensson
Summary: It is found that iron intake and genetically determined iron overload may interact in predisposing to the development of childhood islet autoimmunity and type 1 diabetes. A U-shaped association between iron intake and risk of GAD antibody as the first autoantibody in children was found. High iron intake was associated with an increased risk of IA with insulin as the first autoantibody in children with 2 or more iron risk alleles.
Review
Gastroenterology & Hepatology
Alina Popp, Pilvi Laurikka, Diana Czika, Kalle Kurppa
Summary: Duodenal biopsy is the best method for diagnosing celiac disease, but there is increasing use of serology. Gluten challenge may be necessary if a person has reduced gluten intake before diagnosis. The optimal protocol for the challenge is still unclear.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Hanna Riekki, Linnea Aitokari, Laura Kivela, Siiri Lahti, Pauliina Hiltunen, Nina Vuorela, Heini Huhtala, Timo A. Lakka, Kalle Kurppa
Summary: This study investigated the prevalence, risk factors, and metabolic co-morbidities of metabolic-associated fatty liver disease (MAFLD) in overweight children. The prevalence of MAFLD was 15%, with higher rates in boys than girls, and was associated with gender, puberty stage, disturbances in glucose and lipid metabolism, age, and BMI.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Microbiology
Joachim Johansen, Koji Atarashi, Yasumichi Arai, Nobuyoshi Hirose, Soren J. Sorensen, Tommi Vatanen, Mikael Knip, Kenya Honda, Ramnik J. Xavier, Simon Rasmussen, Damian R. Plichta
Summary: Distinct gut virome composition in centenarians, with higher diversity and lytic activity compared to younger and older individuals, suggests a potential role in healthy aging. Furthermore, phage-encoded sulfate metabolism genes in the centenarian gut microbiome may contribute to mucosal integrity and resistance to pathogens.
NATURE MICROBIOLOGY
(2023)
Editorial Material
Pediatrics
Mikael Knip
Article
Gastroenterology & Hepatology
Iida Ahonen, Pilvi Laurikka, Sara Koskimaa, Heini Huhtala, Katri Lindfors, Katri Kaukinen, Kalle Kurppa, Laura Kivela
Summary: Vomiting and nausea appear to be specific symptoms associated with gluten ingestion in treated celiac disease. However, the overall prevalence and factors related to these symptoms during chronic gluten exposure and acute re-exposure remain unclear.
BMC GASTROENTEROLOGY
(2023)
Editorial Material
Medical Laboratory Technology
David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea R. Horvath, Ake Lernmark, Boyd E. Metzger, David M. Nathan, M. Sue Kirkman
Summary: This article summarizes the scientific evidence and recommendations for laboratory tests used in the diagnosis and management of patients with diabetes mellitus. The quality of the evidence supporting these tests varies, so an expert committee evaluated and compiled evidence-based recommendations. The guidelines were reviewed and revised based on feedback from reviewers and the public. They were then reviewed and approved by multiple professional organizations.
CLINICAL CHEMISTRY
(2023)
Article
Medical Laboratory Technology
David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea R. Horvath, Ake Lernmark, Boyd E. Metzger, David M. Nathan, M. Sue Kirkman
Summary: This passage discusses the use of laboratory tests in the diagnosis and management of diabetes mellitus, and provides evidence-based recommendations for laboratory analysis in screening, diagnosis, or monitoring of diabetes.
CLINICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
M. Karoliina Hirvonen, Niina Lietzen, Robert Moulder, Santosh D. Bhosale, Jaakko Koskenniemi, Mari Vaha-Makila, Mirja Nurmio, Matej Oresic, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Heikki Hyoty, Harri Lahdesmaki, Mikael Knip, Lu Cheng, Riitta Lahesmaa
Summary: By analyzing samples from children with type 1 diabetes, researchers identified the relationship between protein levels and disease progression, which can improve prediction and monitoring of the disease.
SCIENTIFIC REPORTS
(2023)
