A U2-snRNP–independent role of SF3b in promoting mRNA export

Structure and Conformational Dynamics of the Human Spliceosomal B act Complex

(2018) David Haselbach et al.   CELL

Structure of the human activated spliceosome in three conformational states

(2018) Xiaofeng Zhang et al.   CELL RESEARCH

Structure of a human catalytic step I spliceosome

(2018) Xiechao Zhan et al.   SCIENCE

The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts

(2018) Toomas Silla et al.   Cell Reports

Intronless mRNAs transit through nuclear speckles to gain export competence

(2018) Ke Wang et al.   JOURNAL OF CELL BIOLOGY

Mechanistic insights into precursor messenger RNA splicing by the spliceosome

(2017) Yigong Shi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

(2017) Sebastian M Fica et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

(2017) Sebastian M Fica et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export

(2016) Michaela Müller-McNicoll et al.   GENES & DEVELOPMENT

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations

(2016) Constantin Cretu et al.   MOLECULAR CELL

Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)

(2016) Eric L Van Nostrand et al.   NATURE METHODS

Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3′ splice sites within RNA secondary structures

(2016) A K Kesarwani et al.   ONCOGENE

Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A

(2016) Rei Yoshimoto et al.   RNA

The promise of single-cell sequencing

(2013) James Eberwine et al.   NATURE METHODS

Single-cell sequencing-based technologies will revolutionize whole-organism science

(2013) Ehud Shapiro et al.   NATURE REVIEWS GENETICS

Nuclear Retention Prevents Premature Cytoplasmic Appearance of mRNA

(2012) Thomas Beuchert Kallehauge et al.   MOLECULAR CELL

Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA

(2012) Binkai Chi et al.   NUCLEIC ACIDS RESEARCH

Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS

(2012) T. Ohrt et al.   RNA

TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export

(2012) Nicolas Viphakone et al.   Nature Communications

Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing

(2011) Liying Fan et al.   ACS Chemical Biology

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

(2011) L. Malcovati et al.   BLOOD

The Prp19 complex is a novel transcription elongation factor required for TREX occupancy at transcribed genes

(2011) S. Chanarat et al.   GENES & DEVELOPMENT

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway

(2011) J. H. Coyle et al.   RNA

U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

(2010) Daisuke Kaida et al.   NATURE

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing

(2010) R. M. Lardelli et al.   RNA

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

(2009) Zbigniew Warkocki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nuclear mRNA Surveillance in THO/sub2 Mutants Is Triggered by Inefficient Polyadenylation

(2008) Cyril Saguez et al.   MOLECULAR CELL

Isolation of an active step I spliceosome and composition of its RNP core

(2008) Sergey Bessonov et al.   NATURE