Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components

Intersections between Regulated Cell Death and Autophagy

(2019) Francesco Napoletano et al.   TRENDS IN CELL BIOLOGY

The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress

(2019) Morten Luhr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phase II, Multicenter, Single-Arm Study of Mipsagargin (G-202) as a Second-Line Therapy Following Sorafenib for Adult Patients with Progressive Advanced Hepatocellular Carcinoma

(2019) Devalingam Mahalingam et al.   Cancers

Pro-survival autophagy and cancer cell resistance to therapy

(2018) Chandan Kanta Das et al.   CANCER AND METASTASIS REVIEWS

Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress

(2018) Mable Lam et al.   CELL DEATH AND DIFFERENTIATION

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death

(2018) Paula Szalai et al.   CELL CALCIUM

Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3

(2018) Bo Ma et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response

(2018) Emily E. Fink et al.   Cell Reports

Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+depletion and the unfolded protein response

(2017) Pankaj Sehgal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

(2017) Raffaella Iurlaro et al.   MOLECULAR AND CELLULAR BIOLOGY

The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling

(2017) Alexander R. van Vliet et al.   MOLECULAR CELL

Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy

(2017) Wenming Li et al.   Nature Communications

ONC201 activates ER stress to inhibit the growth of triple-negative breast cancer cells

(2017) Xun Yuan et al.   Oncotarget

Hepatitis B virus–triggered autophagy targets TNFRSF10B/death receptor 5 for degradation to limit TNFSF10/TRAIL response

(2016) Gu-Choul Shin et al.   Autophagy

A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer

(2016) Oren Levy et al.   BIOMATERIALS

The molecular mechanisms of XBP-1 gene silencing on IRE1α-TRAF2-ASK1-JNK pathways in oral squamous cell carcinoma under endoplasmic reticulum stress

(2016) Haiying Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours

(2016) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway

(2016) Shoubao Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response

(2016) Max Brown et al.   JOURNAL OF CELL SCIENCE

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships

(2016) András Zeke et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver

(2016) Michael E. Fusakio et al.   MOLECULAR BIOLOGY OF THE CELL

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress

(2016) Florent Dufour et al.   Oncotarget

Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+T-cell activation

(2015) Yair Botbol et al.   Autophagy

Thapsigargin, Origin, Chemistry, Structure-Activity Relationships and Prodrug Development

(2015) Nhu Quynh Doan et al.   CURRENT PHARMACEUTICAL DESIGN

Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs

(2015) Paula Szalai et al.   EXPERIMENTAL CELL RESEARCH

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells

(2015) Tianliang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

(2014) Shane Deegan et al.   Autophagy

Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway

(2014) Rosa Martín-Pérez et al.   CANCER RESEARCH

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells

(2014) C. Kishi-Itakura et al.   JOURNAL OF CELL SCIENCE

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

DENR–MCT1 reinitiates translation

(2014) Eytan Zlotorynski   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast

(2014) C. Humeres et al.   TOXICOLOGY IN VITRO

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation

(2013) Fengli Hu et al.   APOPTOSIS

Modulation of intracellular calcium homeostasis blocks autophagosome formation

(2013) Nikolai Engedal et al.   Autophagy

TRIM13 regulates caspase-8 ubiquitination, translocation to autophagosomes and activation during ER stress induced cell death

(2013) Dhanendra Tomar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress

(2013) Kwang Hong Tay et al.   CELLULAR SIGNALLING

RNF13, a RING Finger Protein, Mediates Endoplasmic Reticulum Stress-induced Apoptosis through the Inositol-requiring Enzyme (IRE1α)/c-Jun NH2-terminal Kinase Pathway

(2013) Muhammad Arshad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

IRE1: ER stress sensor and cell fate executor

(2013) Yani Chen et al.   TRENDS IN CELL BIOLOGY

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

(2012) Luke R. G. Pike et al.   BIOCHEMICAL JOURNAL

Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment

(2012) J. T. Isaacs et al.   CANCER RESEARCH

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

(2012) Y Estornes et al.   CELL DEATH AND DIFFERENTIATION

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

(2012) Lori S. Hart et al.   JOURNAL OF CLINICAL INVESTIGATION

Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

(2012) S. R. Denmeade et al.   Science Translational Medicine

Dissecting the involvement of LC3B and GATE-16 in p62 recruitment into autophagosomes

(2011) Elena Shvets et al.   Autophagy

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8

(2011) M A Laussmann et al.   CELL DEATH AND DIFFERENTIATION

TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation

(2011) Joo-Young Kim et al.   FEBS LETTERS

Inhibition of Protein Degradation Induces Apoptosis through a Microtubule-Associated Protein 1 Light Chain 3-Mediated Activation of Caspase-8 at Intracellular Membranes

(2011) J.-A. Pan et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Endoplasmic-Reticulum Calcium Depletion and Disease

(2011) D. Mekahli et al.   Cold Spring Harbor Perspectives in Biology

The role of TRADD in TRAIL-induced apoptosis and signaling

(2010) Xiumei Cao et al.   FASEB JOURNAL

Critical Roles of Hydrophobicity and Orientation of Side Chains for Inactivation of Sarcoplasmic Reticulum Ca2+-ATPase with Thapsigargin and Thapsigargin Analogs

(2010) Anne-Marie L. Winther et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Regulation of autophagy by ATF4 in response to severe hypoxia

(2010) T Rzymski et al.   ONCOGENE

HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction

(2010) Sanjeev Gupta et al.   PLOS BIOLOGY

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak

(2009) Martina Klee et al.   EMBO JOURNAL

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

(2009) Jenelle M. Timmins et al.   JOURNAL OF CLINICAL INVESTIGATION

The Full-Length Isoform of Human Papillomavirus 16 E6 and Its Splice Variant E6* Bind to Different Sites on the Procaspase 8 Death Effector Domain

(2009) S. S. Tungteakkhun et al.   JOURNAL OF VIROLOGY

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

(2009) Fernanda Lisbona et al.   MOLECULAR CELL

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

(2009) L. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death

(2008) D Gozuacik et al.   CELL DEATH AND DIFFERENTIATION

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY