Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3

CRA(Crosolic Acid) isolated from Actinidia valvata Dunn.Radix induces apoptosis of human gastric cancer cell line BGC823 in vitro via down-regulation of the NF-κB pathway

(2017) Qi-Lai Cheng et al.   FOOD AND CHEMICAL TOXICOLOGY

The Diagnosis and Treatment of Prostate Cancer

(2017) Mark S. Litwin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum

(2017) Bevin C. English et al.   PLoS Pathogens

Transcription Factor C/EBP Homologous Protein in Health and Diseases

(2017) Yuan Yang et al.   Frontiers in Immunology

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

(2016) Angelica M. Merlot et al.   BIOCHEMICAL PHARMACOLOGY

Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis

(2016) Bin Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Patient-reported outcomes in metastatic castration-resistant prostate cancer

(2016) Lesley Fallowfield et al.   Nature Reviews Clinical Oncology

Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer

(2016) Georgios Kallifatidis et al.   SEMINARS IN CANCER BIOLOGY

Prostate cancer and the unfolded protein response

(2016) Margrethe Storm et al.   Oncotarget

Lithocholic acid induces endoplasmic reticulum stress, autophagy and mitochondrial dysfunction in human prostate cancer cells

(2016) Ahmed A. Gafar et al.   PeerJ

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells

(2015) Xianfang Liu et al.   APOPTOSIS

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

Probing the binding interaction of human serum albumin with three bioactive constituents of Eriobotrta japonica leaves: Spectroscopic and molecular modeling approaches

(2015) Qing Wang et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis

(2015) E. Chevet et al.   Cancer Discovery

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer

(2014) Minghua Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation

(2014) M Salazar et al.   CELL DEATH AND DIFFERENTIATION

Suppression of Heat Shock Protein 27 Using OGX-427 Induces Endoplasmic Reticulum Stress and Potentiates Heat Shock Protein 90 Inhibitors to Delay Castrate-resistant Prostate Cancer

(2014) François Lamoureux et al.   EUROPEAN UROLOGY

Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation

(2014) Joo-Hyun Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

New directions in ER stress-induced cell death

(2013) Susan E. Logue et al.   APOPTOSIS

Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress

(2013) Aili Cao et al.   APOPTOSIS

Corosolic acid induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro

(2013) Kyoung Jin Nho et al.   FOOD AND CHEMICAL TOXICOLOGY

Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells

(2013) Hasita Horlad et al.   MOLECULAR NUTRITION & FOOD RESEARCH

GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy

(2013) M Firczuk et al.   Cell Death & Disease

JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells

(2012) F. Chen   CANCER RESEARCH

Pim Kinase Inhibitors Sensitize Prostate Cancer Cells to Apoptosis Triggered by Bcl-2 Family Inhibitor ABT-737

(2011) J. H. Song et al.   CANCER RESEARCH

Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages

(2010) Yukio Fujiwara et al.   CANCER SCIENCE

Plant-based corosolic acid: Future anti-diabetic drug?

(2009) Ganapathy Sivakumar et al.   Biotechnology Journal

Corosolic acid induces apoptosis through mitochondrial pathway and caspases activation in human cervix adenocarcinoma HeLa cells

(2009) Yanfeng Xu et al.   CANCER LETTERS

Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation

(2008) Lei Shi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY