Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin
Authors
Keywords
-
Journal
BRITISH JOURNAL OF CANCER
Volume 122, Issue 1, Pages 62-71
Publisher
Springer Science and Business Media LLC
Online
2019-12-10
DOI
10.1038/s41416-019-0627-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid CancerIn VitroandIn Vivo
- (2018) Shilpa Thakur et al. CLINICAL CANCER RESEARCH
- PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a multi-center, randomized double-blind, placebo-controlled phase 3 trial
- (2018) Sarah Kitson et al. CLINICAL CANCER RESEARCH
- Stem cell-like breast cancer cells with acquired resistance to metformin are sensitive to inhibitors of NADH-dependent CtBP dimerization
- (2018) Arindam Banerjee et al. CARCINOGENESIS
- Targeting HIF-1α is a prerequisite for cell sensitivity to dichloroacetate (DCA) and metformin
- (2016) Sung-Eun Hong et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Measuring the biological effect of presurgical metformin treatment in endometrial cancer
- (2016) V N Sivalingam et al. BRITISH JOURNAL OF CANCER
- Cancer statistics, 2016
- (2016) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Ki-67 in endometrial cancer: scoring optimization and prognostic relevance for window studies
- (2016) Sarah Kitson et al. MODERN PATHOLOGY
- Proliferation and metastatic potential of endometrial cancer cells in response to metformin treatment in a high versus normal glucose environment
- (2016) Amanda de Barros Machado et al. Oncology Letters
- The impact of BMI on surgical complications and outcomes in endometrial cancer surgery—An institutional study and systematic review of the literature
- (2015) Frederique Bouwman et al. GYNECOLOGIC ONCOLOGY
- Global burden of cancer attributable to high body-mass index in 2012: a population-based study
- (2015) Melina Arnold et al. LANCET ONCOLOGY
- Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer
- (2015) Lacey M. Litchfield et al. Oncotarget
- Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses
- (2015) Geir Bredholt et al. Oncotarget
- Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
- (2014) Hannah R. Bridges et al. BIOCHEMICAL JOURNAL
- Effects of metformin on endometrial cancer cell growth in vivo: A preoperative prospective trial
- (2014) Akira Mitsuhashi et al. CANCER
- Metformin impairs growth of endometrial cancer cells via cell cycle arrest and concomitant autophagy and apoptosis
- (2014) Akimasa Takahashi et al. Cancer Cell International
- Anti-diabetic doses of metformin decrease proliferation markers in tumors of patients with endometrial cancer
- (2014) Ido Laskov et al. GYNECOLOGIC ONCOLOGY
- Metformin in reproductive health, pregnancy and gynaecological cancer: established and emerging indications
- (2014) Vanitha N. Sivalingam et al. HUMAN REPRODUCTION UPDATE
- Metformin—mode of action and clinical implications for diabetes and cancer
- (2014) Ida Pernicova et al. Nature Reviews Endocrinology
- Metformin potentiates the anticancer effects of cisplatin under normoxic conditions in vitro
- (2014) TAKASHI UEHARA et al. ONCOLOGY REPORTS
- Mechanisms by Which Low Glucose Enhances the Cytotoxicity of Metformin to Cancer Cells Both In Vitro and In Vivo
- (2014) Yongxian Zhuang et al. PLoS One
- A pilot ‘window of opportunity’ neoadjuvant study of metformin in localised prostate cancer
- (2014) A M Joshua et al. PROSTATE CANCER AND PROSTATIC DISEASES
- The Role of Hypoxia-Inducible Factor-1α, Glucose Transporter-1, (GLUT-1) and Carbon Anhydrase IX in Endometrial Cancer Patients
- (2014) Pawel Sadlecki et al. Biomed Research International
- Antiproliferative and metabolic effects of metformin in a preoperative window clinical trial for endometrial cancer
- (2014) Kevin M. Schuler et al. Cancer Medicine
- Metformin Downregulates the Insulin/IGF-I Signaling Pathway and Inhibits Different Uterine Serous Carcinoma (USC) Cells Proliferation and Migration in p53-Dependent or -Independent Manners
- (2013) Rive Sarfstein et al. PLoS One
- Necrosis related HIF-1α expression predicts prognosis in patients with endometrioid endometrial carcinoma
- (2012) Laura MS Seeber et al. BMC CANCER
- Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study
- (2012) Saroj Niraula et al. BREAST CANCER RESEARCH AND TREATMENT
- Mitochondrial metabolism in cancer metastasis
- (2012) Federica Sotgia et al. CELL CYCLE
- Metformin is synthetically lethal with glucose withdrawal in cancer cells
- (2012) Javier A. Menendez et al. CELL CYCLE
- Dual Effect of Metformin on Breast Cancer Proliferation in a Randomized Presurgical Trial
- (2012) Bernardo Bonanni et al. JOURNAL OF CLINICAL ONCOLOGY
- Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning
- (2012) Michael N. Pollak Cancer Discovery
- The role of hypoxic-inducible factor (HIF1α) and aldolaseC protein in endometrial carcinogenesis: a retrospective study of 279 patients
- (2012) Paulette Mhawech-Fauceglia et al. BMJ Open
- Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial
- (2011) Sirwan Hadad et al. BREAST CANCER RESEARCH AND TREATMENT
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ
- (2011) Diana Whitaker-Menezes et al. CELL CYCLE
- Primary radiation therapy for medically inoperable patients with clinical stage I and II endometrial carcinoma
- (2011) Iwona Podzielinski et al. GYNECOLOGIC ONCOLOGY
- Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models
- (2011) J.-H. Cheong et al. MOLECULAR CANCER THERAPEUTICS
- Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
- (2010) Mahvash Zakikhani et al. BREAST CANCER RESEARCH AND TREATMENT
- Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells
- (2010) I. Ben Sahra et al. CANCER RESEARCH
- Metformin is a potent inhibitor of endometrial cancer cell proliferation—implications for a novel treatment strategy
- (2009) Leigh A. Cantrell et al. GYNECOLOGIC ONCOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search