Article
Pathology
Yanyan Qian, Yiping Li, Yanping Ge, Wei Song, Hong Fan
Summary: In this study, TRERNA1 was found to be significantly upregulated in HCC tissues, accompanied by decreased E-cadherin expression. Elevated TRERNA1 level was associated with high tumor grade, high recurrence rate, and poor survival in patients with HCC. Additionally, TRERNA1 expression level was positively correlated with the activation of HIF-1 alpha, and high TRERNA1 expression level can be an independent risk factor for poor prognosis in HCC patients.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Cell Biology
Lingling He, Wenjing He, Ji Luo, Minjuan Xu
Summary: Identification of key genes and the potential biomarker ENC1 in uterine corpus endometrial carcinoma (UCEC).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Qin Liu, Minghua Yu, Tao Zhang
Summary: This study explores the potential link between oxidative stress and uterine corpus endometrial carcinoma (UCEC). The results demonstrate that a biomarker based on oxidative stress-related genes can reliably predict the clinical outcome of UCEC patients. Furthermore, oxidative stress is found to be associated with immune cell infiltration in UCEC, suggesting its role in UCEC development by activating immune cells.
Article
Oncology
Qinzhen Zhang, Tianxiang Xia, Chenxiang Qi, Jun Du, Chunping Ye
Summary: S100A2 is significantly upregulated in endometrial carcinoma and is associated with poor prognosis. It serves as an independent risk factor for overall survival in patients with endometrial carcinoma. Additionally, S100A2 has a high diagnostic value for endometrial carcinoma. The estrogen and IL-17 signaling pathways are upregulated in the high S100A2 expression group, suggesting their involvement in the cellular mechanisms related to S100A2 in endometrial carcinoma.
Article
Pathology
Lawrence Hsu Lin, Douglas H. R. Allison, Gulisa Turashvili, Varshini Vasudevaraja, Ivy Tran, Jonathan Serrano, Britta Weigelt, Marc Ladanyi, Nadeem R. Abu-Rustum, Matija Snuderl, Sarah Chiang
Summary: This study found that co-occurring sporadic endometrioid endometrial carcinoma (EEC) and endometrioid ovarian carcinoma (EOC) are clonally related, but there is a shift in DNA methylation signatures between the ovarian and endometrial tumors. The results also indicate epigenetic overlap between ovarian and peritoneal tumors, suggesting a role for the tumor microenvironment in the epigenetic modulation of metastatic EEC.
Article
Biochemistry & Molecular Biology
Pawel Mieszczanski, Szmon Januszyk, Nikola Zmarzly, Piotr Ossowski, Konrad Dziobek, Dorota Sagan, Dariusz Boron, Marcin Oplawski, Beniamin Oskar Grabarek
Summary: Reactive oxygen species are by-products of normal cell metabolism, necessary for cell homeostasis, but disruption of balance can lead to oxidative stress and cancer. Regulation of oxidative stress by miRNAs may be a potential therapeutic target. Study identified potential miRNA-gene relationships in endometrial cancer, suggesting miRNAs could influence oxidative stress regulation in cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Marko Hojnik, Snjezana Frkovic Grazio, Ivan Verdenik, Tea Lanisnik Rizner
Summary: The study found that AKR1B1 and AKR1B10 play protective roles in endometrioid endometrial cancer and have the potential as prognostic biomarkers. Patients with higher immunohistochemical levels of both AKR1B1 and AKR1B10 showed better survival rates. However, no significant differences were observed in patients with serous endometrial cancer.
Article
Cell Biology
Lihua Yu, Xiaoli Liu, Xinhui Wang, Huiwen Yan, Qing Pu, Yuqing Xie, Juan Du, Zhiyun Yang
Summary: A novel glycometabolism-related risk score was constructed to predict prognosis and immunotherapy strategies in hepatocellular carcinoma (HCC) patients. The risk score effectively distinguished the prognosis, molecular and immune-related characteristics of HCC patients, and may provide a new strategy for individualized treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Fan Zhang, Junyu Lin, Dechao Feng, Jiayu Liang, Yiping Lu, Zhihong Liu, Xianding Wang
Summary: This study explored the correlation between cuprotosis and clear cell renal cell carcinoma (ccRCC) and developed a cuprotosis-related signature to predict the prognosis of patients with ccRCC. The signature risk score was significantly associated with tumor stage, histological grade, and immune cell infiltrates in ccRCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jie Zheng, Su-Jung Kim, Soma Saeidi, Seong Hoon Kim, Xizhu Fang, Yeon-Hwa Lee, Yanymee N. Guillen-Quispe, Hoang Kieu Chi Ngo, Do-Hee Kim, Doojin Kim, Young-Joon Surh
Summary: Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is highly expressed in hypoxic tumors, including hepato-cellular carcinoma (HCC). Another key transcription factor, nuclear factor erythroid 2-related factor 2 (NRF2), is also overactivated in HCC. The interaction between NRF2 and HIF-1 alpha contributes to HCC growth and progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jinhui Liu, Mengting Xu, Zhipeng Wu, Yan Yang, Shuning Yuan, Jianqiang Liang, Hongjun Zhu
Summary: The study identified RILPL2 as a novel diagnostic and prognostic biomarker in endometrial carcinoma, showing that its high expression is associated with better prognosis and may regulate tumor-infiltrating immune cells and cell cycle.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Xiaoqin Lu, Yanqi Ying, Wenyi Zhang, Rui Li, Jingyan Zhang
Summary: This study demonstrates that MSH2 is highly expressed in various cancer tissues, especially in endometrial cancer. High MSH2 expression is associated with poor prognosis and it may serve as a biomarker for diagnosis and prognosis of endometrial cancer. Additionally, MSH2 expression is correlated with the infiltration of specific immune cells, suggesting its potential as an immunotherapy target.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Oncology
Mayumi Kobayashi Kato, Yuka Asami, Daisuke Takayanagi, Maiko Matsuda, Yoko Shimada, Kengo Hiranuma, Ikumi Kuno, Masaaki Komatsu, Ryuji Hamamoto, Koji Matsumoto, Mitsuya Ishikawa, Takashi Kohno, Tomoyasu Kato, Kouya Shiraishi, Hiroshi Yoshida
Summary: This study aimed to identify prognostic factors in patients with grade 3 endometrial endometrioid carcinoma by evaluating genomic alterations and examining molecular subtypes for clinical outcome prediction. The results showed that CTNNB1 mutation could be a potential biomarker for the prognosis of patients with grade 3 endometrial endometrioid carcinoma, and using the Proactive Molecular Risk Classifier for Endometrial Cancer may help screen Japanese patients with the disease.
Article
Cell Biology
Kazuhisa Hachisuga, Yoshihiro Ohishi, Hiroshi Tomonobe, Hideaki Yahata, Kiyoko Kato, Yoshinao Oda
Summary: G1 endometrioid carcinoma in the elderly is more aggressive than in the young, and elderly status is an independent predictor of shorter progression-free survival. It is suggested that type 1 tumors can be subdivided into type 1a (young age at onset and indolent) and type 1b (old age at onset and relatively aggressive).
Article
Oncology
Nanda Horeweg, Remi A. Nout, Ina M. Jurgenliemk-Schulz, Ludy C. H. W. Lutgens, Jan J. Jobsen, Marie A. D. Haverkort, Jan Willem M. Mens, Annerie Slot, Bastiaan G. Wortman, Stephanie M. de Boer, Ellen Stelloo, Karen W. Verhoeven-Adema, Hein Putter, Vincent T. H. B. M. Smit, Tjalling Bosse, Carien L. Creutzberg
Summary: The molecular classification of endometrial cancer has predictive value for response to radiotherapy in early-stage endometrioid EC. Different molecular subtypes have different responses to adjuvant therapy, and radiotherapy may not be necessary for certain molecular subtypes.
JOURNAL OF CLINICAL ONCOLOGY
(2023)