The effects of statins on microglial cells to protect against neurodegenerative disorders: A mechanistic review

Microvesicles: ROS scavengers and ROS producers

(2019) G. Bodega et al.   Journal of Extracellular Vesicles

NLRP3 inflammasome as a treatment target in atherosclerosis: A focus on statin therapy

(2019) Negin Parsamanesh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Atorvastatin Attenuates Cognitive Deficits and Neuroinflammation Induced by Aβ1–42 Involving Modulation of TLR4/TRAF6/NF-κB Pathway

(2018) Shan Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

(2018) Harald Lund et al.   NATURE IMMUNOLOGY

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K + Channel THIK-1

(2018) Christian Madry et al.   NEURON

Simvastatin accelerates hematoma resolution after intracerebral hemorrhage in a PPARγ-dependent manner

(2018) Yuelong Wang et al.   NEUROPHARMACOLOGY

Modulation of heat shock proteins by statins

(2018) Fatemeh Forouzanfar et al.   PHARMACOLOGICAL RESEARCH

Differences in statin associated neuroprotection corresponds with either decreased production of IL-1β or TNF-α in an in vitro model of neuroinflammation-induced neurodegeneration

(2018) A.J. McFarland et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Deletion of PPARγ in lung macrophages provides an immunoprotective response against M. tuberculosis infection in mice

(2018) Evelyn Guirado et al.   TUBERCULOSIS

Anti-inflammatory Effects of Curcumin in Microglial Cells

(2018) Yangyang Yu et al.   Frontiers in Pharmacology

Microglia and Beyond: Innate Immune Cells As Regulators of Brain Development and Behavioral Function

(2018) Kathryn M. Lenz et al.   Frontiers in Immunology

In silico evidence of direct interaction between statins and β-amyloid

(2018) Neda Shakour et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

Association of Statin Exposure With Histologically Confirmed Idiopathic Inflammatory Myositis in an Australian Population

(2018) Gillian E. Caughey et al.   JAMA Internal Medicine

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury

(2017) Xin Xu et al.   Journal of Neuroinflammation

Statins Reduce Lipopolysaccharide-Induced Cytokine and Inflammatory Mediator Release in an In Vitro Model of Microglial-Like Cells

(2017) A. J. McFarland et al.   MEDIATORS OF INFLAMMATION

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

(2017) Zewen Liu et al.   Oxidative Medicine and Cellular Longevity

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

(2017) Aleksandra Deczkowska et al.   Nature Communications

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease

(2017) Sudhakar R. Subramaniam et al.   Frontiers in Aging Neuroscience

Cellular and Molecular Characterization of Microglia: A Unique Immune Cell Population

(2017) Carole Sousa et al.   Frontiers in Immunology

Expression site of P2RY12 in residential microglial cells in astrocytomas correlates with M1 and M2 marker expression and tumor grade

(2017) Changbin Zhu et al.   Acta Neuropathologica Communications

Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms

(2016) Piotr Chruściel et al.   ATHEROSCLEROSIS

Statins for Prevention of Cardiovascular Disease in Adults

(2016) Roger Chou et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Novel Approaches in Astrocyte Protection: from Experimental Methods to Computational Approaches

(2016) Daniel Garzón et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation

(2016) Frances Corrigan et al.   Journal of Neuroinflammation

PNIPAAM modified mesoporous hydroxyapatite for sustained osteogenic drug release and promoting cell attachment

(2016) Tao Wu et al.   Materials Science & Engineering C-Materials for Biological Applications

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

(2016) Li Du et al.   MOLECULAR NEUROBIOLOGY

TAM receptors regulate multiple features of microglial physiology

(2016) Lawrence Fourgeaud et al.   NATURE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

Simvastatin Therapy in the Acute Stage of Traumatic Brain Injury Attenuates Brain Trauma-Induced Depression-Like Behavior in Rats by Reducing Neuroinflammation in the Hippocampus

(2016) Sher-Wei Lim et al.   Neurocritical Care

Involvement of inhibition of RhoA/Rho kinase signaling in simvastatin-induced amelioration of neuropathic pain

(2016) Masahiro Ohsawa et al.   NEUROSCIENCE

Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells

(2016) D. Kata et al.   NEUROSCIENCE

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting astrocytes in brain injuries: A translational research approach

(2016) George E. Barreto   PROGRESS IN NEUROBIOLOGY

Multifaceted interactions between adaptive immunity and the central nervous system

(2016) J. Kipnis   SCIENCE

The impact of statin therapy on plasma levels of von Willebrand factor antigen

(2016) Amirhossein Sahebkar et al.   THROMBOSIS AND HAEMOSTASIS

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

(2016) Kirti V. Sawant et al.   Scientific Reports

Atorvastatin Prevents Neuroinflammation in Chronic Constriction Injury Rats through Nuclear NFκB Downregulation in the Dorsal Root Ganglion and Spinal Cord

(2015) Li-Wen Chu et al.   ACS Chemical Neuroscience

Statin therapy reduces plasma endothelin-1 concentrations: A meta-analysis of 15 randomized controlled trials

(2015) Amirhossein Sahebkar et al.   ATHEROSCLEROSIS

Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischaemia

(2015) C Potey et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Lack of the scavenger receptor CD36 alters microglial phenotypes after neonatal stroke

(2015) Fan Li et al.   JOURNAL OF NEUROCHEMISTRY

TMEM119 marks a subset of microglia in the human brain

(2015) Jun-ichi Satoh et al.   NEUROPATHOLOGY

Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways

(2015) Junghyung Park et al.   NEUROSCIENCE LETTERS

Association between statin use and plasma D-dimer levels

(2015) Dimitri Mikhailidis et al.   THROMBOSIS AND HAEMOSTASIS

Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation

(2015) Melanie Greter et al.   Frontiers in Immunology

In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed

(2014) I. D. Vainchtein et al.   GLIA

Statin treatment and new-onset diabetes: A review of proposed mechanisms

(2014) Marilyne Brault et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The pharmacology of statins

(2014) Cesare R. Sirtori   PHARMACOLOGICAL RESEARCH

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Statin treatment affects cytokine release and phagocytic activity in primary cultured microglia through two separable mechanisms

(2014) Matthew A Churchward et al.   Molecular Brain

Statin-Related Cognitive Impairment in the Real World

(2014) Jonathan McDonagh   JAMA Internal Medicine

CCL5 and cytokine expression in the rat brain: Differential modulation by chronic morphine and morphine withdrawal

(2013) Lee A. Campbell et al.   BRAIN BEHAVIOR AND IMMUNITY

New Therapies Targeting apoB Metabolism for High-Risk Patients with Inherited Dyslipidaemias: What Can the Clinician Expect?

(2013) Amirhossein Sahebkar et al.   CARDIOVASCULAR DRUGS AND THERAPY

Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system

(2013) Dorothy P. Schafer et al.   CURRENT OPINION IN NEUROBIOLOGY

Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia

(2013) Aleksandra Ellert-Miklaszewska et al.   GLIA

Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression

(2013) Yi Yongjun et al.   JOURNAL OF NEUROIMMUNOLOGY

Simvastatin Attenuates Formalin-Induced Nociceptive Behaviors by Inhibiting Microglial RhoA and p38 MAPK Activation

(2013) Xin-Yi Chen et al.   JOURNAL OF PAIN

Continuous oral administration of atorvastatin ameliorates brain damage after transient focal ischemia in rats

(2013) Tomonari Saito et al.   LIFE SCIENCES

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The role of microglia in adult hippocampal neurogenesis

(2013) Carmelina Gemma et al.   Frontiers in Cellular Neuroscience

Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma

(2013) J Guadagno et al.   Cell Death & Disease

Neuroprotective Effect of Atorvastatin Involves Suppression of TNF-α and Upregulation of IL-10 in a Rat Model of Intracerebral Hemorrhage

(2012) Tu Ewen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Atorvastatin and Simvastatin, but not Pravastatin, Up-regulate LPS-Induced MMP-9 Expression in Macrophages by Regulating Phosphorylation of ERK and CREB

(2012) Dong Kun Lee et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Regulation of microglia development and homeostasis

(2012) Melanie Greter et al.   GLIA

Microglia: The constant gardeners

(2012) Virginia Hughes   NATURE

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Mitochondrial functions in astrocytes: Neuroprotective implications from oxidative damage by rotenone

(2012) Ricardo Cabezas et al.   NEUROSCIENCE RESEARCH

Multifaceted roles of PGE2 in inflammation and cancer

(2012) Masako Nakanishi et al.   Seminars in Immunopathology

Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis

(2011) Céline Van Der Putten et al.   GLIA

Atorvastatin prevents age-related and amyloid-β-induced microglial activation by blocking interferon-γ release from natural killer cells in the brain

(2011) Anthony Lyons et al.   Journal of Neuroinflammation

Simvastatin Therapy Reduces Prooxidant-Antioxidant Balance: Results of a Placebo-Controlled Cross-Over Trial

(2011) Seyyed M. R. Parizadeh et al.   LIPIDS

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Astrocytic-neuronal crosstalk: Implications for neuroprotection from brain injury

(2011) George E. Barreto et al.   NEUROSCIENCE RESEARCH

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Statins and neuroprotection

(2010) W. Gibson Wood et al.   Annals of the New York Academy of Sciences

Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; Implications for prevention of stroke and AD

(2010) D. Famer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microglia dynamics and function in the CNS

(2010) Christopher N Parkhurst et al.   CURRENT OPINION IN NEUROBIOLOGY

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma

(2010) S. G. Temel et al.   JOURNAL OF MOLECULAR HISTOLOGY

Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome

(2010) Amjad Shehadah et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

A historical perspective on the discovery of statins

(2010) Akira ENDO   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Role of interleukin-1β during pain and inflammation

(2009) Ke Ren et al.   BRAIN RESEARCH REVIEWS

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease

(2009) Shaila P. Handattu et al.   NEUROBIOLOGY OF DISEASE

SIMVASTATIN ATTENUATES MICROGLIAL CELLS AND ASTROCYTE ACTIVATION AND DECREASES INTERLEUKIN-1B LEVEL AFTER TRAUMATIC BRAIN INJURY

(2009) Bo Li et al.   NEUROSURGERY

Statins: Mechanisms of neuroprotection

(2009) Peter J. van der Most et al.   PROGRESS IN NEUROBIOLOGY

PPAR Regulation of Inflammatory Signaling in CNS Diseases

(2008) John J. Bright et al.   PPAR Research