Atorvastatin Attenuates Cognitive Deficits and Neuroinflammation Induced by Aβ1–42 Involving Modulation of TLR4/TRAF6/NF-κB Pathway

S-Adenosylmethionine Attenuates Oxidative Stress and Neuroinflammation Induced by Amyloid-β Through Modulation of Glutathione Metabolism

(2017) Qian Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Aging and amyloid β oligomers enhance TLR4 expression, LPS-induced Ca2+ responses, and neuron cell death in cultured rat hippocampal neurons

(2017) María Calvo-Rodríguez et al.   Journal of Neuroinflammation

Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease

(2017) Nophar Geifman et al.   Alzheimers Research & Therapy

Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease

(2017) Julie M. Zissimopoulos et al.   JAMA Neurology

Changes in Cognition and Amyloid-β Processing with Long Term Cholesterol Reduction using Atorvastatin in Aged Dogs

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Atorvastatin May Correct Dyslipidemia in Adult Patients at Risk for Alzheimer's Disease Through an Anti-Inflammatory Pathway

(2016) Liandong Zhao et al.   CNS & Neurological Disorders-Drug Targets

Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO, and PGE2expression and inhibits NF-κB signaling in a mouse model of Alzheimer's disease

(2016) Shi Shi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity

(2016) Xiao-Hui Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Preoperative prediction of cerebral hyperperfusion after carotid endarterectomy using middle cerebral artery signal intensity in 1.5-tesla magnetic resonance angiography followed by cerebrovascular reactivity to acetazolamide using brain perfusion single-photon emission computed tomography

(2016) Jun Yoshida et al.   NEUROLOGICAL RESEARCH

Robust and enduring atorvastatin-mediated memory recovery following the 4-vessel occlusion/internal carotid artery model of chronic cerebral hypoperfusion in middle-aged rats

(2016) Gislene Gonçalves Dias Zaghi et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways

(2016) Fangjiao Song et al.   PLoS One

Statins Inhibit Fibrillary β-Amyloid Induced Inflammation in a Model of the Human Blood Brain Barrier

(2016) Jarred M. Griffin et al.   PLoS One

α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR

(2015) Derek A. Costello et al.   BRAIN BEHAVIOR AND IMMUNITY

Fructose-1,6-bisphosphate suppresses lipopolysaccharide-induced expression of ICAM-1 through modulation of toll-like receptor-4 signaling in brain endothelial cells

(2015) Sun Mi Seok et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model

(2015) Anne-Caroline Schmöle et al.   NEUROBIOLOGY OF AGING

Non-selective NSAIDs improve the amyloid-β-mediated suppression of memory and synaptic plasticity

(2015) Jafar Doost Mohammadpour et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Atorvastatin prevents amyloid-β peptide oligomer-induced synaptotoxicity and memory dysfunction in rats through a p38 MAPK-dependent pathway

(2014) Ling-ling Zhang et al.   ACTA PHARMACOLOGICA SINICA

Astrocytes and neuroinflammation in Alzheimer's disease

(2014) Emma C. Phillips et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Toll-Like Receptors in Alzheimer’s Disease: A Therapeutic Perspective

(2014) Maria Gambuzza et al.   CNS & Neurological Disorders-Drug Targets

Geniposide Attenuates Oligomeric Aβ1-42-Induced Inflammatory Response by Targeting RAGE-Dependent Signaling in BV2 Cells

(2014) Cui Lv et al.   Current Alzheimer Research

Regulator of Calcineurin 1 Gene Transcription is Regulated by Nuclear Factor-kappaB

(2014) Lanlan Zheng et al.   Current Alzheimer Research

Statin use and incident dementia: A nationwide cohort study of Taiwan

(2014) Chian-Ying Chou et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Biological role of Toll-like receptor-4 in the brain

(2014) Teresa Trotta et al.   JOURNAL OF NEUROIMMUNOLOGY

Effects of Ginsenoside Rg1 on the Expression of Toll-Like Receptor 3, 4 and Their Signalling Transduction Factors in the NG108-15 Murine Neuroglial Cell Line

(2014) Bao-Sheng Zhao et al.   MOLECULES

Statins more than cholesterol lowering agents in Alzheimer disease: Their pleiotropic functions as potential therapeutic targets

(2013) Eugenio Barone et al.   BIOCHEMICAL PHARMACOLOGY

Atorvastatin improves cognitive, emotional and motor impairments induced by intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats, an experimental model of Parkinson's disease

(2013) Adalberto A. Castro et al.   BRAIN RESEARCH

Neuroprotective effect of bicyclol in rat ischemic stroke: Down-regulates TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulates claudin-5 expression

(2013) Jian Zhang et al.   BRAIN RESEARCH

Involvement of cysteinyl leukotriene receptor 1 in Aβ1–42-induced neurotoxicity in vitro and in vivo

(2013) Su-Su Tang et al.   NEUROBIOLOGY OF AGING

Ginsenoside Rg1 Decreases Aβ1–42 Level by Upregulating PPARγ and IDE Expression in the Hippocampus of a Rat Model of Alzheimer's Disease

(2013) QianKun Quan et al.   PLoS One

Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer’s disease

(2013) Xiao-Hong Li et al.   Clinical Interventions in Aging

Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony

(2012) Rodrigo Medeiros et al.   EXPERIMENTAL NEUROLOGY

3,6′-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit

(2012) Isabella Russo et al.   JOURNAL OF NEUROCHEMISTRY

Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer’s disease

(2012) Aiguo Xuan et al.   Journal of Neuroinflammation

Loss of Interleukin Receptor-Associated Kinase 4 Signaling Suppresses Amyloid Pathology and Alters Microglial Phenotype in a Mouse Model of Alzheimer's Disease

(2012) B. Cameron et al.   JOURNAL OF NEUROSCIENCE

Statins have therapeutic potential for the treatment of Alzheimer's disease, likely via protection of the neurovascular unit in the AD brain

(2012) Tomoko Kurata et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer’s disease

(2012) Tomoko Kurata et al.   NEUROLOGICAL RESEARCH

Effects of epigallocatechin-3-gallate on pentylenetetrazole-induced kindling, cognitive impairment and oxidative stress in rats

(2012) Tao Xie et al.   NEUROSCIENCE LETTERS

Evaluating the role of Toll-like receptors in diseases of the central nervous system

(2011) Michael Carty et al.   BIOCHEMICAL PHARMACOLOGY

Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease

(2011) Jun Zhou et al.   BRAIN RESEARCH

Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation

(2011) Sang-Ho Choi et al.   JOURNAL OF NEUROCHEMISTRY

Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade

(2011) Hemachander Capiralla et al.   JOURNAL OF NEUROCHEMISTRY

Atorvastatin prevents age-related and amyloid-β-induced microglial activation by blocking interferon-γ release from natural killer cells in the brain

(2011) Anthony Lyons et al.   Journal of Neuroinflammation

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

(2011) Min Song et al.   Journal of Neuroinflammation

Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β1–40 administration in mice: Evidence for dissociation between cognitive deficits and neuronal damage

(2010) Tetsadê C.B. Piermartiri et al.   EXPERIMENTAL NEUROLOGY

Deletion of CD14 Attenuates Alzheimer's Disease Pathology by Influencing the Brain's Inflammatory Milieu

(2010) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Microglial VEGF Receptor Response Is an Integral Chemotactic Component in Alzheimer's Disease Pathology

(2009) J. K. Ryu et al.   JOURNAL OF NEUROSCIENCE

Relevance of Aβ 1-42 Intrahippocampal Injection as An Animal Model of Inflamed Alzheimers Disease Brain

(2008) James McLarnon et al.   Current Alzheimer Research

Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimers Disease

(2008) C. Balistreri et al.   CURRENT PHARMACEUTICAL DESIGN

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

(2008) Sung-Chun Tang et al.   EXPERIMENTAL NEUROLOGY

The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain

(2008) Lubica Cibickova et al.   STEROIDS

Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats

(2008) Rajeshkumar U Koladiya et al.   BMC Pharmacology & Toxicology

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

(2007) Maryse Letiembre et al.   NEUROBIOLOGY OF AGING

Thalidomide inhibition of perturbed vasculature and glial-derived tumor necrosis factor-α in an animal model of inflamed Alzheimer’s disease brain

(2007) Jae K. Ryu et al.   NEUROBIOLOGY OF DISEASE