Small molecule targeting of SHIP1 and SHIP2

Targeting PI3K in cancer: mechanisms and advances in clinical trials

(2019) Jing Yang et al.   Molecular Cancer

AS1949490, an inhibitor of 5′-lipid phosphatase SHIP2, promotes protein kinase C-dependent stabilization of brain-derived neurotrophic factor mRNA in cultured cortical neurons

(2019) Hiroshi Tsuneki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer

(2019) Fabrice André et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis

(2019) C. Pedicone et al.   JOURNAL OF CELL SCIENCE

Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer

(2019) Fatma M. Elmenier et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Overexpression of SH2-Containing Inositol Phosphatase Contributes to Chronic Lymphocytic Leukemia Survival

(2019) Simar Pal Singh et al.   JOURNAL OF IMMUNOLOGY

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

(2018) Sara Mostafavi et al.   NATURE NEUROSCIENCE

Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease

(2018) Ji Woong Lim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The impact of PI 5-phosphatases on phosphoinositides in cell function and human disease

(2018) Ana Raquel Ramos et al.   JOURNAL OF LIPID RESEARCH

PI3K pathway in prostate cancer: All resistant roads lead to PI3K

(2018) Soonbum Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

(2018) Paula Saz-Leal et al.   Cell Reports

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

TREM2 in Neurodegenerative Diseases

(2017) Taylor R. Jay et al.   Molecular Neurodegeneration

Elucidating the Role of TREM2 in Alzheimer’s Disease

(2017) Jason D. Ulrich et al.   NEURON

Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival

(2017) Matthew Gumbleton et al.   Science Signaling

Structural basis for interdomain communication in SHIP2 providing high phosphatase activity

(2017) Johanne Le Coq et al.   eLife

Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival

(2017) Matthew Gumbleton et al.   Science Signaling

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

(2016) Taylor R. Jay et al.   JOURNAL OF NEUROSCIENCE

Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation

(2016) Elmer Hoekstra et al.   Oncotarget

FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model

(2016) Tae-In Kam et al.   eLife

Synthesis and initial evaluation of quinoline-based inhibitors of the SH2-containing inositol 5′-phosphatase (SHIP)

(2015) Christopher M. Russo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling

(2015) Hongzhao Li et al.   CELLULAR SIGNALLING

Drugging PI3K in cancer: refining targets and therapeutic strategies

(2015) Timothy A Yap et al.   CURRENT OPINION IN PHARMACOLOGY

Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia

(2015) M. Malik et al.   HUMAN MOLECULAR GENETICS

SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response toCandida albicans

(2015) Noelia Blanco-Menéndez et al.   JOURNAL OF IMMUNOLOGY

Molecules in medicine mini-review: isoforms of PI3K in biology and disease

(2015) Bart Vanhaesebroeck et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Coordinate Expansion of Murine Hematopoietic and Mesenchymal Stem Cell Compartments by SHIPi

(2015) R. Brooks et al.   STEM CELLS

SHIP1-Expressing Mesenchymal Stem Cells Regulate Hematopoietic Stem Cell Homeostasis and Lineage Commitment During Aging

(2015) Sonia Iyer et al.   STEM CELLS AND DEVELOPMENT

SHIPi Enhances Autologous and Allogeneic Hematopoietic Stem Cell Transplantation

(2015) Sandra Fernandes et al.   EBioMedicine

CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility

(2014) T. Raj et al.   HUMAN MOLECULAR GENETICS

Impaired T-cell survival promotes mucosal inflammatory disease in SHIP1-deficient mice

(2014) M Y Park et al.   Mucosal Immunology

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases

(2014) Lionel Trésaugues et al.   STRUCTURE

Role of SHIP1 in bone biology

(2013) Sonia Iyer et al.   Annals of the New York Academy of Sciences

Role of SHIP1 in cancer and mucosal inflammation

(2013) Sandra Fernandes et al.   Annals of the New York Academy of Sciences

CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing

(2013) M. Malik et al.   JOURNAL OF NEUROSCIENCE

Discovery and Development of Small Molecule SHIP Phosphatase Modulators

(2013) Dennis R. Viernes et al.   MEDICINAL RESEARCH REVIEWS

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

SHIP2: A “NEW” Insulin Pathway Target for Aging Research

(2013) Giulia Accardi et al.   REJUVENATION RESEARCH

What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway

(2013) S. J. Klempner et al.   Cancer Discovery

Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer

(2013) L-Y Huw et al.   Oncogenesis

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery

(2012) Stephen J. Mills et al.   ACS Chemical Biology

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2012) Gwenny Fuhler et al.   MOLECULAR MEDICINE

PTEN Level in Tumor Suppression: How Much Is Too Little?

(2011) A. Carracedo et al.   CANCER RESEARCH

Inhibitor and activator: dual functions for SHIP in immunity and cancer

(2010) William G. Kerr   Annals of the New York Academy of Sciences

Role of SHIP in cancer

(2010) Melisa J. Hamilton et al.   EXPERIMENTAL HEMATOLOGY

Emerging targets for the treatment of obesity

(2010) Akira Suwa et al.   FEBS Journal

SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells

(2010) R. Brooks et al.   JOURNAL OF IMMUNOLOGY

The Inositol Phosphatase SHIP2 Negatively Regulates Insulin/IGF-I Actions Implicated in Neuroprotection and Memory Function in Mouse Brain

(2010) Yoshiyuki Soeda et al.   MOLECULAR ENDOCRINOLOGY

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease

(2009) Lisa M. Ooms et al.   BIOCHEMICAL JOURNAL

The SH2 Domains of Inositol Polyphosphate 5-Phosphatases SHIP1 and SHIP2 Have Similar Ligand Specificity but Different Binding Kinetics

(2009) Yanyan Zhang et al.   BIOCHEMISTRY

SHIP limits immunoregulatory capacity in the T-cell compartment

(2009) M. M. Collazo et al.   BLOOD

Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2

(2009) A Suwa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling

(2009) Christina Gewinner et al.   CANCER CELL

Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1

(2009) Ivan Ivetac et al.   EMBO REPORTS

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

SHIP is required for a functional hematopoietic stem cell niche

(2008) A. L. Hazen et al.   BLOOD

PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity

(2007) Kewei Ma et al.   CELLULAR SIGNALLING