Review
Oncology
Giulia Salvadori, Mario Giuseppe Mirisola, Valter D. Longo
Summary: Hormonal and growth factor alterations can affect cellular processes, leading to cell mutations and malignant transformation, while nutrient restriction has been shown to delay age-related diseases and extend lifespan.
Review
Agriculture, Dairy & Animal Science
Cheng-long Jin, Ya-ai He, Shi-guang Jiang, Xiu-qi Wang, Hui-chao Yan, Hui-zhe Tan, Chun-qi Gao
Summary: Pigeons are important in the poultry industry, but their growth and feeding strategies need to be studied due to their economic importance.
Article
Medicine, General & Internal
Ryoko Katagiri, Motoki Iwasaki, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Melissa A. Merritt, Ji-Yeob Choi, Aesun Shin, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Ichiro Tsuji, Jeongseon Kim, Chisato Nagata, Sue K. Park, Sun-Seog Kweon, Xiao-Ou Shu, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Seiki Kanemura, Yukai Lu, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang
Summary: This study found that late menarche, early menopause, and a higher number of deliveries were significantly associated with a lower risk of endometrial cancer. These findings from a large pooled study of Asian women add to the growing body of evidence on the association between reproductive factors and endometrial cancer risk.
Article
Multidisciplinary Sciences
Maximilian Lassi, Archana Tomar, Gemma Comas-Armangue, Rebekka Vogtmann, Dorieke J. Dijkstra, David Corujo, Raffaele Gerlini, Jonatan Darr, Fabienne Scheid, Jan Rozman, Antonio Aguilar-Pimentel, Omry Koren, Marcus Buschbeck, Helmut Fuchs, Susan Marschall, Valerie Gailus-Durner, Martin Hrabe de Angelis, Torsten Plosch, Alexandra Gellhaus, Raffaele Teperino
Summary: Disruption of paternal circadian rhythm at conception has significant effects on offspring health, including feeding behavior, metabolic health, and oscillatory transcription. Research suggests that the impact of paternal circadian disruption is not directly transferred to offspring via germ cells, but initiated by corticosterone-based parental communication at conception.
Article
Environmental Sciences
Rui Cheng, Jinying Zhang, Ya He, Chenlei Liao, Li Wang, Xuezhen Zhang
Summary: Excessive selenium has toxic effects on fish and can be transmitted to offspring. Maternal exposure to selenium leads to increased selenium content in offspring. Additionally, selenium reduces thyroid hormones, growth hormone, and insulin-like growth factor in fish.
Review
Oncology
Rosamaria Lappano, Lauren A. Todd, Mia Stanic, Qi Cai, Marcello Maggiolini, Francesco Marincola, Violena Pietrobon
Summary: Hormones and growth factors have significant effects on cellular processes and tumor growth, particularly in the context of hypoxia and hypoxia-inducible factors (HIFs). This review summarizes the current understanding of the role of hormones and growth factors in cancer development, with a focus on their interaction with hypoxia and HIFs. It also discusses how hypoxia influences the response to cancer immunotherapy, highlighting the potential impact of a hypoxic microenvironment on the success of adoptive cell therapies.
Review
Developmental Biology
Laura Boulan, Pierre Leopold
Summary: Living organisms exhibit a wide range of sizes, but recent research has identified common principles that govern growth mechanisms. This interdisciplinary research provides insights into various aspects of developmental biology and integrates inputs from different fields.
Article
Multidisciplinary Sciences
Rocio Rodriguez-Valentin, Gabriela Torres-Mejia, Louis Martinez-Matsushita, Angelica Angeles-Llerenas, Liliana Gomez-Flores-Ramos, Roger K. Wolff, Kathy B. Baumgartner, Lisa M. Hines, Elad Ziv, Lourdes Flores-Luna, Luisa Ma Sanchez-Zamorano, Eduardo Ortiz-Panozo, Martha L. Slattery
Summary: This study investigated the modifying effect of genetic variation in energy homeostasis genes on the association between serum concentrations of IGF-1 and IGFBP-3 and breast cancer risk. The findings showed that variants of certain genes modified the association between these serum concentrations and breast cancer risk in premenopausal women.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Marie Helene Schernthaner-Reiter, Peter Wolf, Greisa Vila, Anton Luger
Summary: Pituitary hormone axes play a key role in regulating glucose metabolism and can impact insulin secretion. Patients with pituitary adenomas may experience impaired glucose tolerance, but correcting pituitary dysfunction can often lead to improved glucose homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Bin Sheng, Zichao Wei, Xiaowei Wu, Yi Li, Zhihua Liu
Summary: This study identified USP12 as a key deubiquitinating enzyme for breast cancer metastasis, promoting angiogenesis and leading to metastasis. Overexpression of USP12 decreased DMFS, while high MDK expression predicted lower DMFS and overall survival in breast cancer patients. The USP12-MDK axis may serve as a potential therapeutic target for breast cancer metastasis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Valerija Vujcic Bok, Marko Geric, Goran Gajski, Sanja Gagic, Ana-Marija Domijan
Summary: The aim of this study was to investigate the phytotoxicity and mode of action of bisphenol A (BPA) on Allium cepa roots using a multibiomarker approach. The results showed that even at the lowest concentration tested (1 mg L-1), BPA significantly reduced root length, root fresh weight, and mitotic index. Additionally, it was found that BPA at this concentration also decreased the level of gibberellic acid (GA(3)) in root cells. Higher concentrations of BPA (5 mg L-1) induced production of reactive oxygen species (ROS), oxidative damage to lipids and proteins, and activity of superoxide dismutase. Concentrations of BPA above 25 mg L-1 caused genome damage and synthesis of phytochemicals. These findings highlight the phytotoxic and genotoxic potential of BPA in plants and emphasize the need for environmental monitoring.
Article
Horticulture
Hanlei Chen, Youzhen Lei, Jiajia Sun, Mingyue Ma, Peng Deng, Jin'e Quan, Huitao Bi
Summary: This study investigated the effects of different concentrations of IAA, IBA, and ABT-1 on the rooting and hormone content changes of Australian Mulberry and Kirin Mulberry hardwood cuttings. The results showed that the rooting process could be divided into three stages, and the treatments with 1000 mg/L ABT-1 and 500 mg/L ABT-1 achieved the highest rooting efficiencies. The contents of endogenous hormones exhibited specific trends during the rooting process. ABT-1 was found to be effective in promoting rooting by inducing the synthesis of certain hormones and reducing the contents of others.
Review
Oncology
Helge Waldum
Summary: The rational treatment of diseases, especially cancers, relies on understanding their causes and development processes. The classification of tumors should consider both organ and cell of origin. Hormones and the ability of cells to divide play crucial roles in cancer development.
Article
Multidisciplinary Sciences
Aaron E. Chiou, Chuang Liu, Ines Moreno-Jimenez, Tengteng Tang, Wolfgang Wagermaier, Mason N. Dean, Claudia Fischbach, Peter Fratzl
Summary: Factors secreted by breast cancer may promote disturbed bone growth before metastasis, potentially affecting the initial seeding of tumor cells.
Article
Multidisciplinary Sciences
Yanghongyan Jiang, Yaxin Tian, Bei Feng, Tingting Zhao, Liang Du, Xiaodong Yu, Qian Zhao
Summary: This study aimed to explore a novel molecular probe -[(99)mTc]Tc-HYNIC-FAPI targeting cancer-associated fibroblasts (CAFs). The probe showed good radiochemical purity, stability, and in vitro binding ability to tumor cells, and has the potential to be a promising SPECT/CT imaging probe.
SCIENTIFIC REPORTS
(2023)