Oncogenic role of MIR516A in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy

ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability

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Targeting autophagy in cancer

(2018) Angelique V. Onorati et al.   CANCER

PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein

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Loss of miR-516a-3p mediates upregulation of ABCC5 in prostate cancer and drives its progression

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MicroRNA-411 Downregulation Enhances Tumor Growth by Upregulating MLLT11 Expression in Human Bladder Cancer

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(2018) Antonio Lopez-Beltran et al.   HISTOPATHOLOGY

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

(2017) KyeongJin Kim et al.   GASTROENTEROLOGY

miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer

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Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination Cascades

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MicroRNA-27a contributes to the malignant behavior of gastric cancer cells by directly targeting PH domain and leucine-rich repeat protein phosphatase 2

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XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell

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Overexpression of PTK6 predicts poor prognosis in bladder cancer patients

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Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells

(2016) Haishan Huang et al.   Autophagy

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(2016) Yuguang Liang et al.   Autophagy

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Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis

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MiR-760 overexpression promotes proliferation in ovarian cancer by downregulation of PHLPP2 expression

(2016) Yanbin Liao et al.   GYNECOLOGIC ONCOLOGY

miR-3117 regulates hepatocellular carcinoma cell proliferation by targeting PHLPPL

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(2016) Sachith Gallolu Kankanamalage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2016) Danrui Cui et al.   Cell Division

A plausible role for actin gamma smooth muscle 2 (ACTG2) in small intestinal neuroendocrine tumorigenesis

(2016) Katarina Edfeldt et al.   BMC Endocrine Disorders

MiR-32 contributed to cell proliferation of human breast cancer cells by suppressing of PHLPP2 expression

(2015) Haoming Xia et al.   BIOMEDICINE & PHARMACOTHERAPY

PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure

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Autophagy

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microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells

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miR-205 Targets PTEN and PHLPP2 to Augment AKT Signaling and Drive Malignant Phenotypes in Non-Small Cell Lung Cancer

(2013) J. Cai et al.   CANCER RESEARCH

ETS2 Mediated Tumor Suppressive Function and MET Oncogene Inhibition in Human Non-Small Cell Lung Cancer

(2013) M. Kabbout et al.   CLINICAL CANCER RESEARCH

Downregulation of PHLPP Expression Contributes to Hypoxia-Induced Resistance to Chemotherapy in Colon Cancer Cells

(2013) Yang-An Wen et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclin D1 Downregulation Contributes to Anticancer Effect of Isorhapontigenin on Human Bladder Cancer Cells

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NF-κB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1

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miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells

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Suppression of survival signalling pathways by the phosphatase PHLPP

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The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer

(2012) X Li et al.   ONCOGENE

PHLPP-Mediated Dephosphorylation of S6K1 Inhibits Protein Translation and Cell Growth

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The Metastasis-Associated microRNA miR-516a-3p Is a Novel Therapeutic Target for Inhibiting Peritoneal Dissemination of Human Scirrhous Gastric Cancer

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(2010) Marion T Weigel et al.   ENDOCRINE-RELATED CANCER

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(2009) David P. Bartel   CELL

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Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer

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PHLiPPing the switch on Akt and protein kinase C signaling

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